Determination of Endpoints in Acute and Chronic Toxicity Tests by Using Generalized Linear Models

1991 ◽  
pp. 132-138
Author(s):  
Armand Maul
Keyword(s):  
Generalized Linear Models ◽  
Chronic Toxicity ◽  
Linear Models ◽  
Toxicity Tests ◽  
Acute And Chronic Toxicity

Determination of Enzyme or Binding Constants Using Generalized Linear Models, with Particular Reference to Michaelis–Menten Models

1989 ◽  
Vol 78 (5) ◽  
pp. 413-416
Author(s):  
Gerald Van Belle ◽  
Sue Leurgans ◽  
Pat Friel ◽  
Sunwei Guo ◽  
Mark Yerby
Keyword(s):  
Generalized Linear Models ◽  
Linear Models ◽  
Binding Constants

Reducing Uncertainty in Environmental Risk Assessment (Era): Clearly Defining Acute and Chronic Toxicity Tests

2009 ◽  
Vol 5 (1) ◽  
pp. 175 ◽  
Author(s):  
Torsten Hahn ◽  
Jenny Stauber ◽  
Stuart Dobson ◽  
Paul Howe ◽  
Janet Kielhorn ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Environmental Risk ◽  
Environmental Risk Assessment ◽  
Chronic Toxicity ◽  
Toxicity Tests ◽  
Acute And Chronic Toxicity

scholarly journals ACUTE AND CHRONIC TOXICITY OF SUCCINIC ACID AND PROBIOTICS OF KPM-2 WHEN APPLYED TOGETHER

2021 ◽  
Vol 246 (2) ◽  
pp. 268-271
Author(s):  
N.V. Chubynina ◽  
◽  
Keyword(s):  
Acute Toxicity ◽  
Succinic Acid ◽  
Chronic Toxicity ◽  
Respiratory Arrest ◽  
Hazard Class ◽  
Acute And Chronic Toxicity ◽  
The Dead

The article discusses issues related to the determination of acute and chronic toxicity of succinic acid and probioic KPM-2 when used together in an experiment on white mice. A study of the indicators of acute toxicity showed that the experimental mice were marked by strong excitement, convulsions, death occurred from respiratory arrest during the period of convulsions. Autopsy of the dead mice observed hyperemia of the lungs, plethora of the liver, spleen, kidneys, and asphyxiation of the heart. Yak and probiotic KPM-2, when used together, do not possess cumulative properties according to the classification of Hodge and Sterner and belong to the 4th hazard class.

scholarly journals Acute and Chronic Toxicity of Prothioconazole and its Metabolite Prothioconazole-Desthio To Daphnia Magna

2021 ◽  
Author(s):  
An Xuehua ◽  
Liu Xinju ◽  
Jiang Jinhua ◽  
Wang Feidi ◽  
Lv Lu ◽  
...  
Keyword(s):  
Daphnia Magna ◽  
Chronic Toxicity ◽  
Parent Compound ◽  
Biological Indicators ◽  
Toxicity Tests ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Toxicological Effects ◽  
Acute And Chronic Toxicity ◽  
Growth And Reproduction

Abstract Prothioconazole (PTC) is a broad-spectrum triazole fungicide. Current research has mainly focused on its efficacy and residues, with few studies on its toxicological effects. This study assessed the effects of PTC, and its metabolite prothioconazole-desthio (PTCd), on the inhibition of activity, growth, and reproduction of Daphnia magna using acute and chronic toxicity tests. Additionally, the dose-response relationship was established to determine sensitive biological indicators. The acute toxicity test shows that the 48 h EC50 of PTC and PTCd to D. magna were 2.82 and 5.19 mg/L, respectively. The chronic toxicity of PTC and PTCd to D. magna were 0.00860 and 0.132 mg/L, respectively, with the parent compound being 15.3 times more toxic than its metabolite. The acute to chronic toxicity ratio (ACR) was calculated using chronic toxicity data, with ACR values of 227 and 27.5 for PTC and PTCd, respectively. These results indicate that both PTC and PTCd affect the growth and reproduction of D. magna, and the toxicity of the parent compound is greater than that of its metabolite. In conclusion, the metabolites of this pesticide have sufficient toxicity to harm D. magna at relevant environmental concentrations, and their environmental risk should not be neglected.

Daphnia magna and Ceriodaphnia dubia Have Similar Sensitivity in Standard Acute and Chronic Toxicity Tests

2021 ◽  
Author(s):  
Kristin A. Connors ◽  
Jessica L. Brill ◽  
Teresa Norberg‐King ◽  
Mace G. Barron ◽  
Greg Carr ◽  
...  
Keyword(s):  
Daphnia Magna ◽  
Chronic Toxicity ◽  
Ceriodaphnia Dubia ◽  
Toxicity Tests ◽  
Acute And Chronic Toxicity

Evaluation of the toxic effect of endocrine disruptor Bisphenol A (BPA) in the acute and chronic toxicity tests with Pomacea lineata gastropod

2017 ◽  
Vol 197 ◽  
pp. 1-7 ◽  
Author(s):  
André Lucas Correa de Andrade ◽  
Priscila Rafaela Leão Soares ◽  
Stephannie Caroline Barros Lucas da Silva ◽  
Marília Cordeiro Galvão da Silva ◽  
Thamiris Pinheiro Santos ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Toxic Effect ◽  
Endocrine Disruptor ◽  
Chronic Toxicity ◽  
Toxicity Tests ◽  
Acute And Chronic Toxicity

Daphnia magna as a test animal in acute and chronic toxicity tests

Hydrobiologia ◽  
1978 ◽  
Vol 59 (2) ◽  
pp. 125-134 ◽  
Author(s):  
D. M. M. Adema
Keyword(s):  
Daphnia Magna ◽  
Chronic Toxicity ◽  
Toxicity Tests ◽  
Test Animal ◽  
Acute And Chronic Toxicity
Sign in / Sign up

Export Citation Format

Share Document