Guidance of circumferentially growing axons by the floor plate in the vertebrate central nervous system

1997 ◽  
pp. 323-330
Author(s):  
Fujio Murakami ◽  
Ryuichi Shirasaki
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Floor Plate ◽  
Vertebrate Central Nervous System

Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system

Development ◽  
1998 ◽  
Vol 125 (15) ◽  
pp. 2759-2770 ◽  
Author(s):  
M.P. Matise ◽  
D.J. Epstein ◽  
H.L. Park ◽  
K.A. Platt ◽  
A.L. Joyner
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Floor Plate ◽  
Cell Fates ◽  
Ventral Midline ◽  
Mouse Mutants ◽  
Necessary And Sufficient ◽  
Vertebrate Central Nervous System ◽  
Mouse Central Nervous System

Induction of the floor plate at the ventral midline of the neural tube is one of the earliest events in the establishment of dorsoventral (d/v) polarity in the vertebrate central nervous system (CNS). The secreted molecule, Sonic hedgehog, has been shown to be both necessary and sufficient for this induction. In vertebrates, several downstream components of this signalling pathway have been identified, including members of the Gli transcription factor family. In this study, we have examined d/v patterning of the CNS in Gli2 mouse mutants. We have found that the floor plate throughout the midbrain, hindbrain and spinal cord does not form in Gli2 homozygotes. Despite this, motoneurons and ventral interneurons form in their normal d/v positions at 9.5 to 12.5 days postcoitum (dpc). However, cells that are generated in the region flanking the floor plate, including dopaminergic and serotonergic neurons, were greatly reduced in number or absent in Gli2 homozygous embryos. These results suggest that early signals derived from the notochord can be sufficient for establishing the basic d/v domains of cell differentiation in the ventral spinal cord and hindbrain. Interestingly, the notochord in Gli2 mutants does not regress ventrally after 10.5 dpc, as in normal embryos. Finally, the spinal cord of Gli1/Gli2 zinc-finger-deletion double homozygous mutants appeared similar to Gli2 homozygotes, indicating that neither gene is required downstream of Shh for the early development of ventral cell fates outside the ventral midline.

scholarly journals Floor plate descendants in the ependyma of the adult mouse Central Nervous System

2017 ◽  
Vol 61 (3-4-5) ◽  
pp. 257-265 ◽  
Author(s):  
Sophie Khazanov ◽  
Yael Paz ◽  
Amit Hefetz ◽  
Ben J. Gonzales ◽  
Yaara Netser ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Adult Mouse ◽  
Floor Plate ◽  
Mouse Central Nervous System

A toxin from the venom of the marine snail Conus geographus which acts on the vertebrate central nervous system

Toxicon ◽  
1981 ◽  
Vol 19 (5) ◽  
pp. 691-699 ◽  
Author(s):  
Craig Clark ◽  
Baldomero M. Olivera ◽  
Lourdes J. Cruz
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Marine Snail ◽  
Vertebrate Central Nervous System

Phylogenetic examination of vertebrate central nervous system myelin proteins by electro-immunoblotting

1985 ◽  
Vol 57 (1) ◽  
pp. 97-102 ◽  
Author(s):  
T.V. Waehneldt ◽  
J. Malotka ◽  
N.J. Karin ◽  
J.-M. Matthieu
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Myelin Proteins ◽  
Vertebrate Central Nervous System

REGENERATION IN THE VERTEBRATE CENTRAL NERVOUS SYSTEM: PHYLOGENY, ONTOGENY, AND MECHANISMS

1995 ◽  
Vol 70 (4) ◽  
pp. 597-619 ◽  
Author(s):  
ANDREW J. LARNER ◽  
ALAN R. JOHNSON ◽  
ROGER J. KEYNES
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Vertebrate Central Nervous System
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