Recent Progress in Breast Cancer Genetic Epidemiology

1994 ◽  
pp. 3-13 ◽  
Author(s):  
D. Timothy Bishop ◽  
Nancy Eby ◽  
Jenny Chang-Claude
Keyword(s):  
Breast Cancer ◽  
Genetic Epidemiology ◽  
Recent Progress ◽  
Cancer Genetic

scholarly journals Genetic Epidemiology of Breast Cancer in Latin America

Genes ◽  
2019 ◽  
Vol 10 (2) ◽  
pp. 153 ◽  
Author(s):  
Valentina A. Zavala ◽  
Silvia J. Serrano-Gomez ◽  
Julie Dutil ◽  
Laura Fejerman
Keyword(s):  
Breast Cancer ◽  
Latin America ◽  
Genetic Epidemiology ◽  
Genetic Factors ◽  
Familial Risk ◽  
Common Variants ◽  
Cancer Genetic ◽  
High Penetrance ◽  
Epidemiology Studies ◽  
Modest Effect

The last 10 years witnessed an acceleration of our understanding of what genetic factors underpin the risk of breast cancer. Rare high- and moderate-penetrance variants such as those in the BRCA genes account for a small proportion of the familial risk of breast cancer. Low-penetrance alleles are expected to underlie the remaining heritability. By now, there are about 180 genetic polymorphisms that are associated with risk, most of them of modest effect. In combination, they can be used to identify women at the lowest or highest ends of the risk spectrum, which might lead to more efficient cancer prevention strategies. Most of these variants were discovered in populations of European descent. As a result, we might be failing to discover additional polymorphisms that could explain risk in other groups. This review highlights breast cancer genetic epidemiology studies conducted in Latin America, and summarizes the information that they provide, with special attention to similarities and differences with studies in other populations. It includes studies of common variants, as well as moderate- and high-penetrance variants. In addition, it addresses the gaps that need to be bridged in order to better understand breast cancer genetic risk in Latin America.

scholarly journals Up For A Challenge (U4C): Stimulating innovation in breast cancer genetic epidemiology

PLoS Genetics ◽  
2017 ◽  
Vol 13 (9) ◽  
pp. e1006945 ◽  
Author(s):  
Leah E. Mechanic ◽  
Sara Lindström ◽  
Kenneth M. Daily ◽  
Solveig K. Sieberts ◽  
Christopher I. Amos ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Epidemiology ◽  
Cancer Genetic

scholarly journals Association between breast cancer genetic susceptibility variants and terminal duct lobular unit involution of the breast

2016 ◽  
Vol 140 (4) ◽  
pp. 825-832 ◽  
Author(s):  
Clara Bodelon ◽  
Hannah Oh ◽  
Nilanjan Chatterjee ◽  
Montserrat Garcia-Closas ◽  
Maya Palakal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Susceptibility ◽  
Cancer Genetic ◽  
Terminal Duct Lobular Unit

scholarly journals The recent progress of neoadjuvant chemotherapy in triple negative breast cancer: A short review

2015 ◽  
Vol 5 (2) ◽  
Author(s):  
Michalis Liontos ◽  
Sophia Karageorgopoulou ◽  
Vasiliki Michalaki ◽  
John Contis ◽  
Evangelos Bournakis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Triple Negative Breast Cancer ◽  
Recent Progress ◽  
Triple Negative ◽  
Short Review

scholarly journals Recent Progress in Triple Negative Breast Cancer Research

2016 ◽  
Vol 17 (4) ◽  
pp. 1595-1608 ◽  
Author(s):  
Fatima Zahra Mouh ◽  
Mohammed El Mzibri ◽  
Meriem Slaoui ◽  
Mariam Amrani
Keyword(s):  
Breast Cancer ◽  
Cancer Research ◽  
Triple Negative Breast Cancer ◽  
Recent Progress ◽  
Triple Negative ◽  
Breast Cancer Research

scholarly journals Breast cancer genetic counselling referrals: how comparable are the findings between the UK and the Netherlands?

2011 ◽  
Vol 2 (4) ◽  
pp. 233-247 ◽  
Author(s):  
Akke Albada ◽  
Julie Werrett ◽  
Sandra Van Dulmen ◽  
Jozien M. Bensing ◽  
Cyril Chapman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
The Netherlands ◽  
Genetic Counselling ◽  
Cancer Genetic ◽  
The Uk
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