A Computer Method of Analysing the Structure of Behavioural Models

Author(s):  
M. G. Kendall
Keyword(s):  
2011 ◽  
Vol 383-390 ◽  
pp. 4620-4628
Author(s):  
Olga Ioana Amariei ◽  
Codruţa Oana Hamat ◽  
Liviu Coman ◽  
Cristian Fănică ◽  
Cristian Rudolf

Balancing a production line means to organize the activity of the human operators, to establish the production flux and designing the line, minimizing the idle time for the machines and the operators, through an optimal charge bestowed upon them. WinQSB software offers three methods of solving this type of problem, namely: heuristic techniques (a basic method is specified and an alternative one from all the available ones), Optimizing Best Bud Search and Computer Method of Sequencing Operations for Assembly Lines, presented all in the present paper.


1974 ◽  
Vol 11 (2) ◽  
pp. 117-120
Author(s):  
M. J. P. Bolton ◽  
C. C. Tam

Author(s):  
Climaco J. Metral ◽  
George M. Janini ◽  
Gary M. Muschik ◽  
Haleem J. Issaq

2018 ◽  
Vol 17 (2) ◽  
pp. 71-77
Author(s):  
I. S. Golubeva ◽  
O. V. Goryunova ◽  
N. P. Yavorskaya

Introduction.The existence of the active metabolite (amino acid) residue in the of an indolocarbazole molecule changes physical-chemical and pro-medicinal properties of aminoacid derivatives glycosides of indolocarbazole. The computer method has earlier foretold low probability of their cytotoxic activity in vitro that was confirmed in the MTT-test on 5 lines of tumor cells. The same computer method predicted significant probability of antineoplastic activity of aminoacid derivatives glycosides of indolocarbazole in vivo that demands the experimental check. Purpose of the study– assessment of aminoacid derivatives glycosides of indolocarbazole as potential antitumor medications.Materials and methods.The research of antineoplastic activity of aminoacid derivatives glycosides of indolocarbazole was performed on mice tumoral models – cervical cancer СС5. Abdominal injections were made to CBA/Lac mice 5 times a day with 24 h interval. Observation of animals was continued till their death. The antineoplastic effect of medicines was estimated according to tumor growth inhibition, increase in life expectancy of experiental mice in comparison with control animals.Results.The optimum dose for this number of compounds, equal to 100 mg/kg is titrated. The antineoplastic activity of aminoacid derivatives glycosides of indolocarbazole on the model СС5 is estimated.Conclusions.On the basis of the obtained data the expanded research of antineoplastic properties of the selected 5 aminoacid derivatives glycosides of indolocarbazole is supposed to perform in vivo.


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