Observations on the Effects of Hematopoietic Colony-Stimulating Factors on the Clinical Course of Bone Marrow Transplantation

1993 ◽  
pp. 97-101
Author(s):  
W. P. Peters
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
Clinical Course ◽  
Colony Stimulating Factors

scholarly journals Outcome and clinical course of 100 patients with adenovirus infection following bone marrow transplantation

2000 ◽  
Vol 26 (12) ◽  
pp. 1333-1338 ◽  
Author(s):  
A Baldwin ◽  
H Kingman ◽  
M Darville ◽  
ABM Foot ◽  
D Grier ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
Clinical Course ◽  
Adenovirus Infection

Hemorrhagic cystitis following high-dose chemotherapy and bone marrow transplantation in children with malignancies: incidence, clinical course, and outcome.

1989 ◽  
Vol 7 (2) ◽  
pp. 194-199 ◽  
Author(s):  
L Brugieres ◽  
O Hartmann ◽  
J P Travagli ◽  
E Benhamou ◽  
J L Pico ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
Clinical Course ◽  
Hemorrhagic Cystitis ◽  
High Dose Chemotherapy ◽  
Predisposing Factors ◽  
High Dose ◽  
Viral Agent ◽  
Grade Iii

Two hundred ninety-one courses of high-dose chemotherapy (HDC) with bone marrow transplantation (BMT) in children with malignancies were reviewed in order to assess the incidence, clinical course, outcome, and predisposing factors of hemorrhagic cystitis. Hemorrhagic cystitis occurred in 19 HDC courses (6.5%). Three patients had grade I hematuria linked to thrombopenia, nine had grade II hematuria despite platelet levels greater than 50 x 10(9)/L, and seven had grade III hematuria with clots and bladder obstruction. Severe complications occurred in grade III patients, but no deaths were directly linked to the cystitis. Fourteen patients recovered within two to 120 days of onset. The other patients died before the cystitis resolved, either of a relapse of the malignancy or of infection. Predisposing factors were age (increased incidence in older children), conditioning regimen containing cyclophosphamide, previous vesical irradiation, association with prolonged aplasia, and hepatic complications. The role of busulfan was also probable. No viral agent was found.

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