Molecular Biology of Calcium Channels

1993 ◽  
pp. 98-110
Author(s):  
P. Spreyer ◽  
J. K. Franz ◽  
A. Eller ◽  
P. Rae ◽  
A. Unterbeck
Keyword(s):  
Molecular Biology ◽  
Calcium Channels

Molecular Biology of T-Type Calcium Channels

2006 ◽  
Vol 5 (6) ◽  
pp. 605-609 ◽  
Author(s):  
E. Perez-Reyes ◽  
P. Lory
Keyword(s):  
Molecular Biology ◽  
Calcium Channels

scholarly journals Molecular biology of calcium channels

1995 ◽  
Vol 48 (4) ◽  
pp. 1111-1124 ◽  
Author(s):  
Edward Perez-Reyes ◽  
Toni Schneider
Keyword(s):  
Molecular Biology ◽  
Calcium Channels

Voltage-Gated Calcium Channels and Idiopathic Generalized Epilepsies

2006 ◽  
Vol 86 (3) ◽  
pp. 941-966 ◽  
Author(s):  
Houman Khosravani ◽  
Gerald W. Zamponi
Keyword(s):  
Molecular Biology ◽  
Calcium Channels ◽  
Brain Activity ◽  
Network Activity ◽  
Seizure Susceptibility ◽  
Idiopathic Generalized Epilepsy ◽  
Comprehensive Overview ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels ◽  
Generalized Epilepsy

The idiopathic generalized epilepsies encompass a class of epileptic seizure types that exhibit a polygenic and heritable etiology. Advances in molecular biology and genetics have implicated defects in certain types of voltage-gated calcium channels and their ancillary subunits as important players in this form of epilepsy. Both T-type and P/Q-type channels appear to mediate important contributions to seizure genesis, modulation of network activity, and genetic seizure susceptibility. Here, we provide a comprehensive overview of the roles of these channels and associated subunits in normal and pathological brain activity within the context of idiopathic generalized epilepsy.

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