Between the Normal State and an Exceptional State Form: Authoritarian Competitive Statism and the Crisis of Democracy in Europe

2019 ◽  
pp. 23-44
Author(s):  
Lukas Oberndorfer
Keyword(s):  
Normal State ◽  
State Form

A Free Energy Perturbation Approach to Estimate the Intrinsic Solubilities of Drug-like Small Molecules

2019 ◽  
Author(s):  
Sayan Mondal ◽  
Gary Tresadern ◽  
Jeremy Greenwood ◽  
Byungchan Kim ◽  
Joe Kaus ◽  
...  
Keyword(s):  
Solid State ◽  
Small Molecules ◽  
Three Dimensional ◽  
Aqueous Solubility ◽  
Computational Approach ◽  
Free Energy Perturbation ◽  
Perturbation Approach ◽  
Energy Perturbation ◽  
State Form ◽  
Good Agreement

<p>Optimizing the solubility of small molecules is important in a wide variety of contexts, including in drug discovery where the optimization of aqueous solubility is often crucial to achieve oral bioavailability. In such a context, solubility optimization cannot be successfully pursued by indiscriminate increases in polarity, which would likely reduce permeability and potency. Moreover, increasing polarity may not even improve solubility itself in many cases, if it stabilizes the solid-state form. Here we present a novel physics-based approach to predict the solubility of small molecules, that takes into account three-dimensional solid-state characteristics in addition to polarity. The calculated solubilities are in good agreement with experimental solubilities taken both from the literature as well as from several active pharmaceutical discovery projects. This computational approach enables strategies to optimize solubility by disrupting the three-dimensional solid-state packing of novel chemical matter, illustrated here for an active medicinal chemistry campaign.</p>

STABLE hc/e VORTICES IN SUPERCONDUCTORS WITH SPIN-CHARGE SEPARATION

1992 ◽  
Vol 06 (05n06) ◽  
pp. 509-526
Author(s):  
Subir Sachdev
Keyword(s):  
Magnetic Field ◽  
Magnetic Flux ◽  
Normal State ◽  
Phenomenological Model ◽  
Charge Separation ◽  
Cuprate Superconductors ◽  
Superconducting Phase ◽  
Low Energy ◽  
Large N ◽  
Normal State Properties

A phenomenological model, F, of the superconducting phase of systems with spin-charge separation and antiferromagnetically induced pairing is studied. Above Hc1, magnetic flux can always pierce the superconductor in vortices with flux hc/2e, but regimes are found in which vortices with flux hc/e are preferred. Little-Park and other experiments, which examine periodicities with a varying magnetic field, always observe a period of hc/2e. The low energy properties of a symplectic large-N expansion of a model of the cuprate superconductors are argued to be well described by F. This analysis and some normal state properties of the cuprates suggest that hc/e vortices should be stable at the lowest dopings away from the insulating state at which superconductivity first occurs.

High magnetic-field evolution of the in-plane angular magnetoresistance of electron-doped Sr1−xLaxCuO2 in the normal state

2021 ◽  
Vol 103 (1) ◽  
Author(s):  
V. P. Jovanović ◽  
H. Raffy ◽  
Z. Z. Li ◽  
G. Reményi ◽  
P. Monceau
Keyword(s):  
Magnetic Field ◽  
High Magnetic Field ◽  
Normal State ◽  
Field Evolution

scholarly journals States Transitions Inference of Postpartum Depression Based on Multi-State Markov Model

2021 ◽  
Vol 18 (14) ◽  
pp. 7449
Author(s):  
Juan Xiong ◽  
Qiyu Fang ◽  
Jialing Chen ◽  
Yingxin Li ◽  
Huiyi Li ◽  
...  
Keyword(s):  
Postpartum Depression ◽  
Markov Model ◽  
Normal State ◽  
Sojourn Time ◽  
Transition Probabilities ◽  
Transition Probability ◽  
Public Health Problem ◽  
Mental States ◽  
Hazard Ratio ◽  
Multiple Time

Background: Postpartum depression (PPD) has been recognized as a severe public health problem worldwide due to its high incidence and the detrimental consequences not only for the mother but for the infant and the family. However, the pattern of natural transition trajectories of PPD has rarely been explored. Methods: In this research, a quantitative longitudinal study was conducted to explore the PPD progression process, providing information on the transition probability, hazard ratio, and the mean sojourn time in the three postnatal mental states, namely normal state, mild PPD, and severe PPD. The multi-state Markov model was built based on 912 depression status assessments in 304 Chinese primiparous women over multiple time points of six weeks postpartum, three months postpartum, and six months postpartum. Results: Among the 608 PPD status transitions from one visit to the next visit, 6.2% (38/608) showed deterioration of mental status from the level at the previous visit; while 40.0% (243/608) showed improvement at the next visit. A subject in normal state who does transition then has a probability of 49.8% of worsening to mild PPD, and 50.2% to severe PPD. A subject with mild PPD who does transition has a 20.0% chance of worsening to severe PPD. A subject with severe PPD is more likely to improve to mild PPD than developing to the normal state. On average, the sojourn time in the normal state, mild PPD, and severe PPD was 64.12, 6.29, and 9.37 weeks, respectively. Women in normal state had 6.0%, 8.5%, 8.7%, and 8.8% chances of progress to severe PPD within three months, nine months, one year, and three years, respectively. Increased all kinds of supports were associated with decreased risk of deterioration from normal state to severe PPD (hazard ratio, HR: 0.42–0.65); and increased informational supports, evaluation of support, and maternal age were associated with alleviation from severe PPD to normal state (HR: 1.46–2.27). Conclusions: The PPD state transition probabilities caused more attention and awareness about the regular PPD screening for postnatal women and the timely intervention for women with mild or severe PPD. The preventive actions on PPD should be conducted at the early stages, and three yearly; at least one yearly screening is strongly recommended. Emotional support, material support, informational support, and evaluation of support had significant positive associations with the prevention of PPD progression transitions. The derived transition probabilities and sojourn time can serve as an importance reference for health professionals to make proactive plans and target interventions for PPD.

Normal state Fermi surface of cuprates: effects of bilayer interactions

2003 ◽  
Vol 391 (1) ◽  
pp. 61-66
Author(s):  
Amit Pratap ◽  
Govind
Keyword(s):  
Fermi Surface ◽  
Normal State

Assessment of Fermi-liquid description for the normal state of high-Tcsuperconductors

1989 ◽  
Vol 39 (16) ◽  
pp. 11633-11647 ◽  
Author(s):  
Ju H. Kim ◽  
K. Levin ◽  
A. Auerbach
Keyword(s):  
Normal State ◽  
Fermi Liquid
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