Clostridium Botulinum C3 Exoenzyme and C3-Like Transferases

2000 ◽  
pp. 207-233 ◽  
Author(s):  
K. Aktories ◽  
H. Barth ◽  
I. Just
Keyword(s):  
Clostridium Botulinum ◽  
C3 Exoenzyme

ADP-ribosylation of a small size GTP-binding protein in bovine neutrophils by the C3 exoenzyme of Clostridium botulinum and effect on the cell motility

1991 ◽  
Vol 180 (2) ◽  
pp. 615-622 ◽  
Author(s):  
Marie-Jose Stasia ◽  
Alain Jouan ◽  
Nicolas Bourmeyster ◽  
Patrice Boquet ◽  
Pierre V. Vignais
Keyword(s):  
Cell Motility ◽  
Clostridium Botulinum ◽  
Binding Protein ◽  
Gtp Binding Protein ◽  
Adp Ribosylation ◽  
Gtp Binding ◽  
C3 Exoenzyme ◽  
Bovine Neutrophils

Clostridium botulinum C3 Exoenzyme and Studies on Rho Proteins

2008 ◽  
pp. 71-83 ◽  
Author(s):  
C. D. Nobes ◽  
A. Hall
Keyword(s):  
Clostridium Botulinum ◽  
Rho Proteins ◽  
C3 Exoenzyme

scholarly journals Sequential activation of heterotrimeric and monomeric G proteins mediates PLD activity in smooth muscle

2001 ◽  
Vol 280 (3) ◽  
pp. G381-G388 ◽  
Author(s):  
K. S. Murthy ◽  
H. Zhou ◽  
J. R. Grider ◽  
G. M. Makhlouf
Keyword(s):  
Smooth Muscle ◽  
G Proteins ◽  
Clostridium Botulinum ◽  
Dominant Negative ◽  
Calphostin C ◽  
Kinase C ◽  
C3 Exoenzyme ◽  
Sequential Activation ◽  
Adp Ribosylation Factor ◽  
Dependent Pathway

The identity of G proteins mediating CCK-stimulated phospholipase D (PLD) activity was determined in intestinal smooth muscle cells. CCK-8 activated Gq/11, G13, and G12, and the monomeric G proteins Ras-homology protein (RhoA) and ADP ribosylation factor (ARF). Activation of RhoA, but not ARF, was mediated by G13 and inhibited by Gα13 antibody. CCK-stimulated PLD activity was partly mediated by RhoA and could be inhibited to the same extent (47 ± 2% to 53 ± 6%) by 1) a dominant negative RhoA mutant, 2) RhoA antibody or Gα13 antibody, and 3) Clostridium botulinum C3 exoenzyme. PLD activity was also inhibited by ARF antibody, and the effect was additive to that of RhoA antibody or C3 exoenzyme. PLD activity was inhibited by calphostin C, bisindolylmaleimide I, and a selective protein kinase C (PKC)-α inhibitor; the inhibition was additive to that of ARF and RhoA antibodies and C3 exoenzyme. In contrast, activated G12 was not coupled to RhoA or ARF, and Gα12 antibody augmented PLD activity. Thus agonist-stimulated PLD activity is mediated additively by G13-dependent RhoA and by ARF and PKC-α and is modulated by an inhibitory G12-dependent pathway.

Clostridium Botulinum C3 Exoenzyme Stimulates GLUT4-Mediated Glucose Transport, but Not Glycogen Synthesis, in 3T3-L1 Adipocytes—A Potential Role of rho?

1996 ◽  
Vol 229 (2) ◽  
pp. 430-439 ◽  
Author(s):  
Nina van den Berghe ◽  
L.Felipe Barros ◽  
Michelle G.H.van Mackelenbergh ◽  
H.Michiel J. Krans
Keyword(s):  
Glucose Transport ◽  
Clostridium Botulinum ◽  
Potential Role ◽  
Glycogen Synthesis ◽  
C3 Exoenzyme

scholarly journals Uptake of Clostridium botulinum C3 Exoenzyme into Intact HT22 and J774A.1 Cells

Toxins ◽  
2015 ◽  
Vol 7 (2) ◽  
pp. 380-395 ◽  
Author(s):  
Astrid Rohrbeck ◽  
Leonie von Elsner ◽  
Sandra Hagemann ◽  
Ingo Just
Keyword(s):  
Clostridium Botulinum ◽  
C3 Exoenzyme

Copurification of rho protein and the rho-GDP dissociation inhibitor from bovine neutrophil cytosol. Effect of phosphoinositides on rho ADP-ribosylation by the C3 exoenzyme of Clostridium botulinum

Biochemistry ◽  
1992 ◽  
Vol 31 (51) ◽  
pp. 12863-12869 ◽  
Author(s):  
Nicolas Bourmeyster ◽  
Marie Jose Stasia ◽  
Jerome Garin ◽  
Jean Gagnon ◽  
Patrice Boquet ◽  
...  
Keyword(s):  
Clostridium Botulinum ◽  
Adp Ribosylation ◽  
Rho Protein ◽  
C3 Exoenzyme ◽  
Gdp Dissociation Inhibitor ◽  
Bovine Neutrophil

scholarly journals Molecular recognition of an ADP-ribosylating Clostridium botulinum C3 exoenzyme by RalA GTPase

2005 ◽  
Vol 102 (15) ◽  
pp. 5357-5362 ◽  
Author(s):  
K. P. Holbourn ◽  
J. M. Sutton ◽  
H. R. Evans ◽  
C. C. Shone ◽  
K. R. Acharya
Keyword(s):  
Molecular Recognition ◽  
Clostridium Botulinum ◽  
C3 Exoenzyme

The intermediate filament protein vimentin is essential for axonotrophic effects of Clostridium botulinum C3 exoenzyme

2016 ◽  
Vol 139 (2) ◽  
pp. 234-244 ◽  
Author(s):  
Andrej Adolf ◽  
George Leondaritis ◽  
Astrid Rohrbeck ◽  
Britta Johanna Eickholt ◽  
Ingo Just ◽  
...  
Keyword(s):  
Intermediate Filament ◽  
Clostridium Botulinum ◽  
Intermediate Filament Protein ◽  
C3 Exoenzyme ◽  
Filament Protein

scholarly journals Differentiation-induced increase in Clostridium botulinum C3 exoenzyme-catalyzed ADP-ribosylation of the small GTP-binding protein Rho

1994 ◽  
Vol 223 (3) ◽  
pp. 909-916 ◽  
Author(s):  
Gerhard FRITZ ◽  
Ingo JUST ◽  
Peter WOLLENBERG ◽  
Klaus AKTORIES
Keyword(s):  
Clostridium Botulinum ◽  
Binding Protein ◽  
Gtp Binding Protein ◽  
Adp Ribosylation ◽  
Gtp Binding ◽  
C3 Exoenzyme
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