A new concept for the mechanism of Ca+ +-regulation of muscle contraction. Implications for physiological and pharmacological approaches to modulate contractile function of myocardium

1991 ◽  
pp. 83-92
Author(s):  
B. Brenner
Keyword(s):  
Muscle Contraction ◽  
Contractile Function ◽  
Regulation Of Muscle Contraction

scholarly journals Dysfunction of muscle contraction with impaired intracellular Ca2+ handling in skeletal muscle and the effect of exercise training in male db/db mice

2019 ◽  
Vol 126 (1) ◽  
pp. 170-182 ◽  
Author(s):  
Hiroaki Eshima ◽  
Yoshifumi Tamura ◽  
Saori Kakehi ◽  
Kyoko Nakamura ◽  
Nagomi Kurebayashi ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Exercise Training ◽  
Muscle Contraction ◽  
Contractile Function ◽  
Contractile Force ◽  
Contractile Dysfunction ◽  
Muscle Contractile ◽  
Type 2 Diabetic

Type 2 diabetes is characterized by reduced contractile force production and increased fatigability of skeletal muscle. While the maintenance of Ca2+ homeostasis during muscle contraction is a requisite for optimal contractile function, the mechanisms underlying muscle contractile dysfunction in type 2 diabetes are unclear. Here, we investigated skeletal muscle contractile force and Ca2+ flux during contraction and pharmacological stimulation in type 2 diabetic model mice ( db/db mice). Furthermore, we investigated the effect of treadmill exercise training on muscle contractile function. In male db/db mice, muscle contractile force and peak Ca2+ levels were both lower during tetanic stimulation of the fast-twitch muscles, while Ca2+ accumulation was higher after stimulation compared with control mice. While 6 wk of exercise training did not improve glucose tolerance, exercise did improve muscle contractile dysfunction, peak Ca2+ levels, and Ca2+ accumulation following stimulation in male db/db mice. These data suggest that dysfunctional Ca2+ flux may contribute to skeletal muscle contractile dysfunction in type 2 diabetes and that exercise training may be a promising therapeutic approach for dysfunctional skeletal muscle contraction. NEW & NOTEWORTHY The purpose of this study was to examine muscle contractile function and Ca2+ regulation as well as the effect of exercise training in skeletal muscle in obese diabetic mice ( db/db). We observed impairment of muscle contractile force and Ca2+ regulation in a male type 2 diabetic animal model. These dysfunctions in muscle were improved by 6 wk of exercise training.

The Role of the Interaction of Ca2+ with Troponin in the Regulation of Muscle Contraction

1976 ◽  
pp. 93-106 ◽  
Author(s):  
J. D. Potter ◽  
B. Nagy ◽  
J. H. Collins ◽  
J. C. Seidel ◽  
P. Leavis ◽  
...  
Keyword(s):  
Muscle Contraction ◽  
Regulation Of Muscle Contraction

Regulation of Muscle Contraction by Ca Ion

1980 ◽  
pp. 183-194 ◽  
Author(s):  
S. Ebashi ◽  
Y. Nonomura ◽  
K. Kohama ◽  
T. Kitazawa ◽  
T. Mikawa
Keyword(s):  
Muscle Contraction ◽  
Regulation Of Muscle Contraction

scholarly journals Calcium regulation of muscle contraction

1975 ◽  
Vol 15 (7) ◽  
pp. 707-723 ◽  
Author(s):  
A.G. Szent-Györgyi
Keyword(s):  
Muscle Contraction ◽  
Calcium Regulation ◽  
Regulation Of Muscle Contraction
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