Aging of Intestinal Stem Cells in Drosophila Melanogaster

2015 ◽  
pp. 85-104
Author(s):  
Benoît Biteau
Keyword(s):  
Stem Cells ◽  
Drosophila Melanogaster ◽  
Intestinal Stem Cells

Intestinal stem cells with its applications

2020 ◽  
Author(s):  
Yijun Qi
Keyword(s):  
Stem Cells ◽  
Intestinal Stem Cells

Epithelial Regeneration after Doxorubicin Arises Primarily from Early Progeny of Active Intestinal Stem Cells

2020 ◽  
Author(s):  
Breanna Sheahan ◽  
Ally N. Freeman ◽  
Theresa M. Keeley ◽  
Linda C. Samuelson ◽  
Jatin Roper ◽  
...  
Keyword(s):  
Stem Cells ◽  
Intestinal Stem Cells ◽  
Epithelial Regeneration

Benzoic acid treated Drosophila melanogaster: the genetic disruption of larval brain stem cells and non-neural cells during metamorphosis

2021 ◽  
Author(s):  
Tridip Chatterjee ◽  
Swapan Kumar Ghosh ◽  
Shauvik Paik ◽  
Amit Chakravarty ◽  
Ashim Kumar Basak
Keyword(s):  
Stem Cells ◽  
Drosophila Melanogaster ◽  
Benzoic Acid ◽  
Brain Stem ◽  
Neural Cells ◽  
Larval Brain

scholarly journals Context-dependent responses of Drosophila intestinal stem cells to intracellular reactive oxygen species

Redox Biology ◽  
2021 ◽  
Vol 39 ◽  
pp. 101835
Author(s):  
Fei Chen ◽  
Run Su ◽  
Shiwei Ni ◽  
Yan Liu ◽  
Jiexiang Huang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Reactive Oxygen ◽  
Intracellular Reactive Oxygen Species ◽  
Intestinal Stem Cells ◽  
Oxygen Species ◽  
Context Dependent

scholarly journals Circadian Regulation of Mitochondrial Uncoupling and Lifespan

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 740-741
Author(s):  
Matthew Ulgherait
Keyword(s):  
Stem Cells ◽  
Circadian Rhythm ◽  
Uncoupling Protein ◽  
Intestinal Stem Cells ◽  
Intestinal Stem Cell ◽  
Cellular Respiration ◽  
Circadian Regulation ◽  
Lifespan Extension ◽  
Diet Restriction ◽  
Mitochondrial Uncoupling

Abstract Because old age is associated with defects in circadian rhythm, loss of circadian regulation is thought to be pathogenic and contribute to mortality. We show instead that loss of specific circadian clock components Period (Per) and Timeless (Tim) in male Drosophila significantly extends lifespan. This lifespan extension is not mediated by canonical diet-restriction longevity pathways, but is due to altered cellular respiration via increased mitochondrial uncoupling. Lifespan extension of per mutants depends on mitochondrial uncoupling in the intestine. Moreover, up-regulated uncoupling protein UCP4C in intestinal stem cells and enteroblasts is sufficient to extend lifespan and preserve proliferative homeostasis in the gut with age. Consistent with inducing a metabolic state that prevents over-proliferation, mitochondrial uncoupling drugs also extend lifespan and inhibit intestinal stem cell overproliferation due to aging or even tumorigenesis. These results demonstrate that circadian-regulated intestinal mitochondrial uncoupling controls longevity in Drosophila and suggest a new potential anti-aging therapeutic target.

Sign in / Sign up

Export Citation Format

Share Document