Divalent Cations Enhance Short-Time Fluoride Exposure-Induced Inhibition on Acid Production by Streptococcus mutans

2012 ◽  
pp. 178-180
Author(s):  
Hitomi Domon-Tawaraya ◽  
Kazuko Nakajo ◽  
Jumpei Washio ◽  
Satoshi Fukumoto ◽  
Nobuhiro Takahashi
Keyword(s):  
Streptococcus Mutans ◽  
Acid Production ◽  
Divalent Cations ◽  
Fluoride Exposure ◽  
Short Time

Short-time effect of fluoride on acid production by Streptococcus mutans

2010 ◽  
pp. 269-270
Author(s):  
Hitomi Domon ◽  
Kazuko Nakajo ◽  
Jumpei Washio ◽  
Harumi Miyasawa-Hori ◽  
Satoshi Fukumoto ◽  
...  
Keyword(s):  
Streptococcus Mutans ◽  
Acid Production ◽  
Time Effect ◽  
Short Time

Divalent Cations Enhance Fluoride Binding to Streptococcus mutans and Streptococcus sanguinis Cells and Subsequently Inhibit Bacterial Acid Production

2013 ◽  
Vol 47 (2) ◽  
pp. 141-149 ◽  
Author(s):  
H. Domon-Tawaraya ◽  
K. Nakajo ◽  
J. Washio ◽  
T. Ashizawa ◽  
T. Ichino ◽  
...  
Keyword(s):  
Streptococcus Mutans ◽  
Acid Production ◽  
Divalent Cations ◽  
Streptococcus Sanguinis

Inhibition of Acid Production by Streptococcus mutans NCTC 10449 by Zinc and the Effect of Metal Speciation

1991 ◽  
Vol 25 (6) ◽  
pp. 431-437 ◽  
Author(s):  
G.K. Watson ◽  
D. Cummins ◽  
F.J.G. van der Ouderaa
Keyword(s):  
Streptococcus Mutans ◽  
Acid Production ◽  
Metal Speciation

scholarly journals Baicalein Inhibits Streptococcus mutans Biofilms and Dental Caries-Related Virulence Phenotypes

Antibiotics ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 215
Author(s):  
Aparna Vijayakumar ◽  
Hema Bhagavathi Sarveswari ◽  
Sahana Vasudevan ◽  
Karthi Shanmugam ◽  
Adline Princy Solomon ◽  
...  
Keyword(s):  
Dental Caries ◽  
Streptococcus Mutans ◽  
Biofilm Formation ◽  
Acid Production ◽  
Cell Surface Hydrophobicity ◽  
Surface Hydrophobicity ◽  
Oral Disease ◽  
Public Healthcare ◽  
Surface Attachment ◽  
First Time

Dental caries, the most common oral disease, is a major public healthcare burden and affects more than three billion people worldwide. The contemporary understanding of the need for a healthy microbiome and the emergence of antimicrobial resistance has resulted in an urgent need to identify compounds that curb the virulence of pathobionts without microbial killing. Through this study, we have demonstrated for the first time that 5,6,7-trihydroxyflavone (Baicalein) significantly downregulates crucial caries-related virulence phenotypes in Streptococcus mutans. Baicalein significantly inhibited biofilm formation by Streptococcus mutans UA159 (MBIC50 = 200 μM), without significant growth inhibition. Notably, these concentrations of baicalein did not affect the commensal S. gordonii. Strikingly, baicalein significantly reduced cell surface hydrophobicity, autoaggregation and acid production by S. mutans. Mechanistic studies (qRT-PCR) showed downregulation of various genes regulating biofilm formation, surface attachment, quorum sensing, acid production and competence. Finally, we demonstrate the potential translational value of baicalein by reporting synergistic interaction with fluoride against S. mutans biofilms.

Effect of Anti-oxidants on Growth and Lactic Acid Production by Streptococcus mutans

1985 ◽  
Vol 64 (7) ◽  
pp. 1016-1018 ◽  
Author(s):  
L.I. Kupp ◽  
S. Rosen ◽  
F.M. Beck
Keyword(s):  
Lactic Acid ◽  
Streptococcus Mutans ◽  
Acid Production ◽  
Lactic Acid Production
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