Oral tolerance mediated by dextrin-specific suppressor T cells, migrating from Peyer’s patches to spleen

1990 ◽  
pp. 274-275 ◽  
Author(s):  
M E Roux ◽  
M C López
1994 ◽  
Vol 157 (2) ◽  
pp. 439-447 ◽  
Author(s):  
Leonilda M.B. Santos ◽  
Ahmad Al-Sabbagh ◽  
Ana Londono ◽  
Howard L. Weiner

1995 ◽  
Vol 17 (7) ◽  
pp. 611-617 ◽  
Author(s):  
Hiroshi Fujisawa ◽  
Takeshi Nishimura ◽  
Muneo Inaba ◽  
Susumu Ikehara

1984 ◽  
Vol 85 (1) ◽  
pp. 264-269 ◽  
Author(s):  
S.H.M. Jeurissen ◽  
T. Sminia ◽  
G. Kraal

1979 ◽  
Vol 149 (6) ◽  
pp. 1371-1378 ◽  
Author(s):  
B S Kim

Normal BALB/c spleen cells are unresponsive in vitro to the phosphorylcholine (PC) determinant in the presence of anti-idiotype antibodies specific for the TEPC-15 myeloma protein (T15) which carries an idiotypic determinant indistinguishable from that of most anti-PC antibodies in BALB/c mice. The possibility that idiotype-specific suppressor cells may be generated during the culture period was examined by coculturing the cells with untreated syngeneic spleen cells. Cells that had been preincubated with anti-T15 idiotype (anti-T15id) antibodies and a PC-containing antigen, R36a for 3 d, were capable of specifically suppressing the anti-PC response of fresh normal spleen cells, indicating that idiotype-specific suppressor cells were generated during the culture period. The presence of specific antigen also appeared to be necessary because anti-T15id antibodies and a control antigen, DNP-Lys-Ficoll, were not capable of generating such suppressor cells. Suppressor cells were induced only in the population of spleen cells nonadherent to nylon wool and the suppressive activity was abrogated by treatment with anti-Thy 1.2 serum and complement. These results indicate that anti-idiotype antibodies and specific antigen can generate idiotype-specific suppressor T cells in vitro. These in vitro results may reflect in vivo mechanisms of idiotype suppression.


1977 ◽  
Vol 53 (5) ◽  
pp. 395-401 ◽  
Author(s):  
Sastry V.S. Gollapudi ◽  
Leon S. Kind

1986 ◽  
Vol 98 (2) ◽  
pp. 544-551 ◽  
Author(s):  
Margot Zöller ◽  
Dagmar Lopatta ◽  
Giancarlo Andrighetto

1994 ◽  
Vol 8 (1) ◽  
pp. 65
Author(s):  
N. Ishii ◽  
N. Tamura ◽  
H. Nakajima

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