Phase-Transfer Catalysis-Transition Metal Cocatalyzed Reactions

1994 ◽  
pp. 594-621
Author(s):  
Charles M. Starks ◽  
Charles L. Liotta ◽  
Marc E. Halpern
Keyword(s):  
Transition Metal ◽  
Phase Transfer Catalysis ◽  
Phase Transfer

Highly selective difluoromethylations of β-keto amides with TMSCF2Br under mild conditions

Synlett ◽  
2021 ◽  
Author(s):  
yakun wang ◽  
Shuaifei Wang ◽  
Conghui Zhang ◽  
Ting Zhao ◽  
Yanqin Hu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Amino Alcohol ◽  
Phase Transfer Catalysis ◽  
Phase Transfer ◽  
Mild Conditions ◽  
Convenient Access

Without employing any transition metal and other additives, efficient methods for selective difluoromethylations of β-keto amides with TMSCF2Br reagent have been developed under mild conditions. This protocol allows a convenient access to various α-difluoromethyl β-keto amides with excellent yields (up to 93%) and high C/O regioselectivities (up to 99:1). The C/O selectivity of β-keto amides could be easily reversed and controlled by simply changing the base. This protocol can be easily scaled up and the C-difluoromethylation product could be reduced into CF2H contained amino-alcohol derivatives. Moreover, the first enantioselective electrophilic difluoromethylation of β-keto amides has been achieved by phase-transfer catalysis.

scholarly journals Highly selective difluoromethylations of β-keto amides with TMSCF2Br under mild conditions

2021 ◽  
Author(s):  
Yakun Wang ◽  
Shuaifei Wang ◽  
Conghui Zhang ◽  
Ting Zhao ◽  
Yanqin Hu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Amino Alcohol ◽  
Phase Transfer Catalysis ◽  
Phase Transfer ◽  
Mild Conditions ◽  
Convenient Access

Without employing any transition metal and other additives, efficient methods for selective difluoromethylations of β-keto amides with TMSCF2Br reagent have been developed under alkaline and open-air conditions. This protocol allows a convenient access to various α-difluoromethyl β-keto amides with excellent yields (up to 93%) and high C/O regioselectivities (up to 99:1). The C/O selectivity of β-keto amides could be easily reversed and controlled by simply changing the base. This protocol can be easily scaled up and the C-difluoromethylation product could be reduced into amino-alcohol derivatives. Moreover, the first enantioselective electrophilic difluoromethylation of β-keto amides has been achieved by phase-transfer catalysis.

ChemInform Abstract: Oxidative Addition of Thiols to Substituted Olefins in the Presence of Transition Metal Peroxo Complexes under Phase-Transfer Catalysis Conditions.

ChemInform ◽  
2010 ◽  
Vol 30 (44) ◽  
pp. no-no
Author(s):  
S. A. Zhirukhina ◽  
Al-Haddad Thanaa ◽  
A. V. Tarakanova ◽  
V. V. Litvinova ◽  
N. S. Kulikov ◽  
...  
Keyword(s):  
Transition Metal ◽  
Phase Transfer Catalysis ◽  
Phase Transfer ◽  
Oxidative Addition ◽  
Peroxo Complexes

The Role of Phase Transfer Catalysis in the Microwave-Assisted N-Benzylation of Amides, Imides and N-Heterocycles

2009 ◽  
Vol 6 (7) ◽  
pp. 529-534 ◽  
Author(s):  
Istvan Greiner ◽  
Fanni Sypaseuth ◽  
Alajos Grun ◽  
Eva Karsai ◽  
Gyorgy Keglevich
Keyword(s):  
Phase Transfer Catalysis ◽  
Phase Transfer ◽  
Microwave Assisted

Green Application of Phase-Transfer Catalysis in Oxidation: A Comprehensive Review

2020 ◽  
Vol 17 (4) ◽  
pp. 405-411
Author(s):  
Chuan-Hui Wang ◽  
Chen-Fu Liu ◽  
Guo-Wu Rao
Keyword(s):  
Organic Chemistry ◽  
Green Chemistry ◽  
Oxidation Reaction ◽  
Phase Transfer Catalysis ◽  
Phase Transfer ◽  
Important Application ◽  
Oxidation Reactions ◽  
Comprehensive Review ◽  
Phase Transfer Catalysts ◽  
Onium Salts

Oxidation reactions have emerged as one of the most versatile tools in organic chemistry. Various onium salts such as ammonium, phosphonium, arsonium, bismuthonium, tellurium have been used as phase transfer catalysts in many oxidation reactions. Certainly, considerable catalysts have been widely used in Phase-Transfer Catalysis (PTC). This review focuses on the application of PTC in various oxidation reaction. Furthermore, PTC also conforms to the concept of “Green Chemistry”. <p></p> • Oxidation has become one of the most widely used tools in organic chemistry and phase transfer catalysts has been widely used in oxidation. <p></p> • The application of phase transfer catalysts in oxidation reaction will be summarized. <p></p> • Phase transfer catalysts have important application in various oxidation reaction.

scholarly journals Synthesis of sec-Butyl Disulfide by Phase Transfer Catalysis

2015 ◽  
Vol 27 (9) ◽  
pp. 3208-3210
Author(s):  
Xinqi Liu ◽  
Jia Wang ◽  
Songfang Zhao ◽  
Guoqin Hu
Keyword(s):  
Phase Transfer Catalysis ◽  
Phase Transfer
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