Background:
Helicobacter pylori causes dangerous and deadly diseases such as gastric cancer and duodenal ulcers. Eradication and treatment of this bacterium are very important due to the deadly diseases caused by H. pylori and the
high cost of treatment for countries. So, we present a complete list of the most important causes of failure in the treatment
and eradication of H. pylori, and addresses new therapeutic methods that may be effective in controlling this bacterium in
the future.
Results:
Many efforts have been made to control and eradicate this bacterium over the years, but no success has been
achieved since its eradication is a complex process affected by the bacterial properties and host factors. Previous studies
have shown that various factors are involved in failure to eradicate H. pylori, such as new genotypes of the bacterium with higher pathogenicity, inappropriate patient cooperation, mutations, biofilm formation and dormant
forms that cause antibiotic resistance, acidic stomach pH, high bacterial load, smoking, immunosuppressive features and intracellular occurrence of H. pylori. On the other hand, recent studies reported that the use of probiotics, nanoparticles, antimicrobial peptides, natural product and vaccine can be helpful in the treatment and eradication of H. pylori infections.
Conclusion:
Eradication of H. pylori is crucial for the treatment of important diseases such as gastric cancer. Therefore, it
seems that identifying the failure causes of treating this bacterium can be helpful in controlling the infections. Besides, further studies on new therapeutic strategies may help eradicate H. pylori in the future.
Estimating the Force of Infection with Helicobacter pylori in Japan
