Diseases Caused by Genetic or Congenital Defects in the Immune System or Skin Immune System

2016 ◽  
pp. 259-277
Author(s):  
Albert Gutierrez ◽  
Mark R. Pittelkow ◽  
Liyan Xi ◽  
Xiaowen Huang ◽  
Sweta Rai
Keyword(s):  
Immune System ◽  
Congenital Defects ◽  
Skin Immune System

Aging and the skin immune system

1997 ◽  
Vol 133 (10) ◽  
pp. 1256-1262 ◽  
Author(s):  
C. Sunderkotter
Keyword(s):  
Immune System ◽  
Skin Immune System

Immunity at the surface: Homeostatic mechanisms of the skin immune system

Life Sciences ◽  
1996 ◽  
Vol 58 (18) ◽  
pp. 1485-1507 ◽  
Author(s):  
Ifor R. Williams ◽  
Thomas S. Kupper
Keyword(s):  
Immune System ◽  
Skin Immune System ◽  
Homeostatic Mechanisms

Complement as a Part of the Skin Immune System

2004 ◽  
pp. 327-348
Author(s):  
Syed Asghar ◽  
Krisztina Timár ◽  
Marcel Pasch
Keyword(s):  
Immune System ◽  
Skin Immune System

scholarly journals Microarray analysis of novel genes involved in HSV-2 infection

2021 ◽  
Author(s):  
Hao Zhang ◽  
Tao Liu
Keyword(s):  
Immune System ◽  
Network Analysis ◽  
Protein Interaction ◽  
Protein Interaction Network ◽  
Experimental Studies ◽  
Interaction Network ◽  
The Body ◽  
Gene Analysis ◽  
Functional Enrichment ◽  
Skin Immune System

Abstract Background: Herpes simplex virus type 2 infects the body and becomes an incurable and recurring disease. The pathogenesis of HSV-2 infection is not completely clear.Methods: We analyze the GSE18527 dataset in the GEO database in this paper to obtain distinctively displayed genes(DDGs)in the total sequential RNA of the biopsies of normal and lesioned skin groups, healed skin and lesioned skin groups of genital herpes patients, respectively.The related data of 3 cases of normal skin group, 4 cases of lesioned group and 6 cases of healed group were analyzed.The histospecific gene analysis , functional enrichment and protein interaction network analysis of the differential genes were also performed, and the critical components were selected.Results: 40 up-regulated genes and 43 down-regulated genes were isolated by differential performance assay.Histospecific gene analysis of DDGs suggested that the most abundant system for gene expression was the skin, immune system and the nervous system.Through the construction of core gene combinations, protein interaction network analysis and selection of histospecific distribution genes, 17 associated genes were selected：CXCL10,MX1,ISG15,IFIT1,IFIT3,IFIT2,OASL,ISG20,RSAD2,GBP1,IFI44L,DDX58,USP18,CXCL11,GBP5,GBP4 and CXCL9.The above genes are mainly located in the skin, immune system, nervous system and reproductive system.Conclusion:This paper elucidates an effective approach for a new mechanism of HSV-2 infection, and the molecular mechanism of the selected core genes in the process of HSV-2 infection requires future experimental studies.

scholarly journals Exploring the role of IL-15 in the skin immune system

2002 ◽  
Vol 11 (5) ◽  
pp. 481-482
Author(s):  
Silvia Bulfone-Paus
Keyword(s):  
Immune System ◽  
Skin Immune System

scholarly journals Skin Immune Landscape: Inside and Outside the Organism

2017 ◽  
Vol 2017 ◽  
pp. 1-17 ◽  
Author(s):  
Florence Abdallah ◽  
Lily Mijouin ◽  
Chantal Pichon
Keyword(s):  
Immune System ◽  
Immune Responses ◽  
Skin Surface ◽  
Negative Influence ◽  
Background Information ◽  
Symbiotic Relationship ◽  
Skin Microbiota ◽  
Effector Cells ◽  
Skin Immune System ◽  
The Impact

The skin is an essential organ to the human body protecting it from external aggressions and pathogens. Over the years, the skin was proven to have a crucial immunological role, not only being a passive protective barrier but a network of effector cells and molecular mediators that constitute a highly sophisticated compound known as the “skin immune system” (SIS). Studies of skin immune sentinels provided essential insights of a complex and dynamic immunity, which was achieved through interaction between the external and internal cutaneous compartments. In fact, the skin surface is cohabited by microorganisms recognized as skin microbiota that live in complete harmony with the immune sentinels and contribute to the epithelial barrier reinforcement. However, under stress, the symbiotic relationship changes into a dysbiotic one resulting in skin disorders. Hence, the skin microbiota may have either positive or negative influence on the immune system. This review aims at providing basic background information on the cutaneous immune system from major cellular and molecular players and the impact of its microbiota on the well-coordinated immune responses in host defense.

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