A Multi-Scale Study of Industrial Fermentation Processes and Their Optimization

2004 ◽  
pp. 97-150 ◽  
Author(s):  
Siliang Zhang ◽  
Ju Chu ◽  
Yingping Zhuang
Keyword(s):  
Industrial Fermentation ◽  
Fermentation Processes ◽  
Multi Scale

A systematic approach for scaling Aspergillus niger industrial fermentation processes

2012 ◽  
Vol 29 ◽  
pp. S13
Author(s):  
Margarita Salazar Pena ◽  
Morten S. Hansen ◽  
Stuart M. Stocks
Keyword(s):  
Aspergillus Niger ◽  
Systematic Approach ◽  
Industrial Fermentation ◽  
Fermentation Processes

Metabolic engineering of microbial competitive advantage for industrial fermentation processes

Science ◽  
2016 ◽  
Vol 353 (6299) ◽  
pp. 583-586 ◽  
Author(s):  
A. Joe Shaw ◽  
Felix H. Lam ◽  
Maureen Hamilton ◽  
Andrew Consiglio ◽  
Kyle MacEwen ◽  
...  
Keyword(s):  
Metabolic Engineering ◽  
Competitive Advantage ◽  
Industrial Fermentation ◽  
Fermentation Processes

scholarly journals Bacterial Toxin-Antitoxin Gene System as Containment Control in Yeast Cells

2000 ◽  
Vol 66 (12) ◽  
pp. 5524-5526 ◽  
Author(s):  
P. Kristoffersen ◽  
G. B. Jensen ◽  
K. Gerdes ◽  
J. Piškur
Keyword(s):  
Escherichia Coli ◽  
Saccharomyces Cerevisiae ◽  
Yeast Cells ◽  
Eukaryotic Cells ◽  
Bacterial Toxin ◽  
Containment Control ◽  
Industrial Fermentation ◽  
Fermentation Processes ◽  
Gene System ◽  
Potential Applications

ABSTRACT The potential of a bacterial toxin-antitoxin gene system for use in containment control in eukaryotes was explored. The Escherichia coli relE and relB genes were expressed in the yeastSaccharomyces cerevisiae. Expression of therelE gene was highly toxic to yeast cells. However, expression of the relB gene counteracted the effect ofrelE to some extent, suggesting that toxin-antitoxin interaction also occurs in S. cerevisiae. Thus, bacterial toxin-antitoxin gene systems also have potential applications in the control of cell proliferation in eukaryotic cells, especially in those industrial fermentation processes in which the escape of genetically modified cells would be considered highly risky.

Current Developments in Industrial Fermentation Processes

2021 ◽  
pp. 23-96
Author(s):  
Mehrdad Niakousari ◽  
Maryam Razmjooei ◽  
Maryam Nejadmansouri ◽  
Francisco J. Barba ◽  
Krystian Marszałek ◽  
...  
Keyword(s):  
Industrial Fermentation ◽  
Fermentation Processes

scholarly journals Genome-wide analysis of maltose utilization and regulation in aspergilli

Microbiology ◽  
2009 ◽  
Vol 155 (12) ◽  
pp. 3893-3902 ◽  
Author(s):  
Wanwipa Vongsangnak ◽  
Margarita Salazar ◽  
Kim Hansen ◽  
Jens Nielsen
Keyword(s):  
Regulatory Protein ◽  
Regulatory System ◽  
Industrial Fermentation ◽  
Maltose Permease ◽  
Fermentation Processes ◽  
Cellular Physiology ◽  
Maltose Transport ◽  
Genome Wide ◽  
Major Route ◽  
Maltose Utilization

Maltose utilization and regulation in aspergilli is of great importance for cellular physiology and industrial fermentation processes. In Aspergillus oryzae, maltose utilization requires a functional MAL locus, composed of three genes: MALR encoding a regulatory protein, MALT encoding maltose permease and MALS encoding maltase. Through a comparative genome and transcriptome analysis we show that the MAL regulon system is active in A. oryzae while it is not present in Aspergillus niger. In order to utilize maltose, A. niger requires a different regulatory system that involves the AmyR regulator for glucoamylase (glaA) induction. Analysis of reporter metabolites and subnetworks illustrates the major route of maltose transport and metabolism in A. oryzae. This demonstrates that overall metabolic responses of A. oryzae occur in terms of genes, enzymes and metabolites when the carbon source is altered. Although the knowledge of maltose transport and metabolism is far from being complete in Aspergillus spp., our study not only helps to understand the sugar preference in industrial fermentation processes, but also indicates how maltose affects gene expression and overall metabolism.

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