Fine structure and permeability of capillaries in the stria vascularis and spiral ligament of the inner ear of the guinea pig

1982 ◽  
Vol 226 (3) ◽  
Author(s):  
Masafumi Sakagami ◽  
Toru Matsunaga ◽  
PauloH. Hashimoto
Keyword(s):  
Fine Structure ◽  
Guinea Pig ◽  
Inner Ear ◽  
Stria Vascularis ◽  
Spiral Ligament

The fine structure of the stria vascularis of the guinea-pig inner ear

1965 ◽  
Vol 67 (5) ◽  
pp. 600-619 ◽  
Author(s):  
E. L. Rodriguez Echandia ◽  
Mario H. Burgos
Keyword(s):  
Fine Structure ◽  
Guinea Pig ◽  
Inner Ear ◽  
Stria Vascularis

The localization and specificity of guinea pig inner ear antigenic epitopes

1995 ◽  
Vol 109 (1) ◽  
pp. 19-23 ◽  
Author(s):  
Ming-Yu Cao ◽  
Michel Gersdorff ◽  
Naïma Deggouj ◽  
Jean-Paul Tomasi
Keyword(s):  
Guinea Pig ◽  
Inner Ear ◽  
Basilar Membrane ◽  
Stria Vascularis ◽  
Polyacrylamide Gel Electrophoresis ◽  
Spiral Ligament ◽  
Antigenic Epitope ◽  
Acoustic Nerve ◽  
The Brain ◽  
Antigenic Epitopes

AbstractIn this study, we investigated the relative localization of some antigenic epitopes in the inner ear. The inner ear protein antigens were extracted from various parts of the guinea pig inner ear. Brain, kidney, lung, heart and liver extracts were also obtained. We found by SDS-polyacrylamide gel electrophoresis that total inner ear extracts separated into three high concentration polypeptide bands with molecular weights of approximately 30, 42, 58 kd and three low density bands of 20,25 and 35 kd. The 30 kd band was found mainly in the extract of the spiral ganglion and the acoustic nerve in the modiolus. The 42 and 58 kd bands were detected in the extract of the spiral ligament and the stria vascularis. The Organ of Corti and the basilar membrane extract gave rise to three bands of 30,42 and 58 kd. Twenty-eight of the 75 sera from patients with inner ear disease reacted with the 30 and 58 kd bands of the inner ear protein extracts by immunoblotting. Sixteen of these 28 positive sera were then used to probe immunoblots of the brain, kidney, lung, heart and liver extracts. The 58 kd band was also found in protein extracts of the brain, the lung and the liver. This study suggests that the 30 kd antigenic epitope may be mainly related to the acoustic nerve and that the 58 kd antigenic epitope is not cochlear specific.

Molecular cloning of theCochgene of guinea pig inner ear and its expression analysis in cultured fibrocytes of the spiral ligament

2010 ◽  
Vol 130 (8) ◽  
pp. 868-880
Author(s):  
Lishu Li ◽  
Tetsuo Ikezono ◽  
Kuwon Sekine ◽  
Susumu Shindo ◽  
Tomohiro Matsumura ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Inner Ear ◽  
Molecular Cloning ◽  
Expression Analysis ◽  
Spiral Ligament

The fine structure of the stria vascularis of the cat inner ear

1966 ◽  
Vol 118 (2) ◽  
pp. 631-663 ◽  
Author(s):  
R. Hinojosa ◽  
E. L. Rodriguez-Echandia
Keyword(s):  
Fine Structure ◽  
Inner Ear ◽  
Stria Vascularis

CIRCULATION OF THE SPIRAL LIGAMENT AND STRIA VASCULARIS OF LIVING GUINEA PIG: Experimental Study

1954 ◽  
Vol 59 (6) ◽  
pp. 731-738 ◽  
Author(s):  
F. L. WEILLE ◽  
S. R. GARGANO ◽  
R. PFISTER ◽  
D. MARTINEZ ◽  
J. W. IRWIN
Keyword(s):  
Experimental Study ◽  
Guinea Pig ◽  
Stria Vascularis ◽  
Spiral Ligament

Influence of carbon dioxide laser irradiation on the morphology and function of guinea pig cochlea

2005 ◽  
Vol 119 (9) ◽  
pp. 684-692 ◽  
Author(s):  
DongDong Ren ◽  
JingWU Sun ◽  
GuangLun Wan ◽  
Feng Yang ◽  
Fang Shen
Keyword(s):  
Nitric Oxide ◽  
Carbon Dioxide ◽  
Guinea Pig ◽  
Inner Ear ◽  
Laser Irradiation ◽  
Carbon Dioxide Laser ◽  
Organ Of Corti ◽  
Spiral Ligament ◽  
Laser Application ◽  
Brainstem Response

Both experimental and clinical studies have demonstrated that carbon dioxide laser is suitable for stapedotomy. The aim of this study was to investigate morphological, electrophysiological and functional changes in the inner ear after irradiation with CO2 laser set with different energy parameters.A cochleostomy in the basal cochlear turn of guinea pig cochleae was performed with CO2 laser of 1, 2 and 3 w, respectively. The cochleae were removed three weeks after laser irradiation. The auditory evoked brainstem response (ABR) was measured before and after laser application and immediately before removal of the cochlea. Immunohistochemical methods were used to examine inducible nitric oxide synthase (iNOS/NOSII) and heat-shock protein 70(Hsp70) concentrations in the cochlea after laser application. The organ of Corti was studied by scanning electron microscopy.Worse hearing loss was observed in animals receiving higher-power CO2 laser. These findings correlated with more intense injury of the cochlear ultrastructure and with positiveexpression of iNOS and Hsp70 in spiral ganglion cells, nerve fibres, supporting cells of the organ of Corti and cells of the spiral ligament.The CO2 laser as a noncontact procedure is shown to be effective and safe if the total amount of energy is kept within the limits applied in this study. Nitric oxide and stressproteins play important roles in the traumatic mechanism of the inner ear, which are related tohearing loss and injury of the ultrastructure of the inner ear.

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