Cytoplasmic actin and cochlear outer hair cell motility

1989 ◽  
Vol 257 (1) ◽  
Author(s):  
Norma Slepecky
Keyword(s):  
Hair Cell ◽  
Cell Motility ◽  
Outer Hair Cell ◽  
Cytoplasmic Actin ◽  
Outer Hair Cell Motility

scholarly journals Rho GTPases Mediate the Regulation of Cochlear Outer Hair Cell Motility by Acetylcholine

2000 ◽  
Vol 275 (36) ◽  
pp. 28000-28005 ◽  
Author(s):  
Federico Kalinec ◽  
Ming Zhang ◽  
Raul Urrutia ◽  
Gilda Kalinec
Keyword(s):  
Hair Cell ◽  
Cell Motility ◽  
Rho Gtpases ◽  
Outer Hair Cell ◽  
Outer Hair Cell Motility

The role of outer hair cell motility in cochlear tuning

1991 ◽  
Vol 1 (2) ◽  
pp. 215-220 ◽  
Author(s):  
Peter Dallos ◽  
M.Elizabeth Corey
Keyword(s):  
Hair Cell ◽  
Cell Motility ◽  
Outer Hair Cell ◽  
Outer Hair Cell Motility ◽  
Cochlear Tuning

The nature of the generator of outer hair cell motility

1991 ◽  
Vol 89 (4B) ◽  
pp. 1931-1931
Author(s):  
Burt N. Evans ◽  
Richard Hallworth ◽  
Peter Dallos
Keyword(s):  
Hair Cell ◽  
Cell Motility ◽  
Outer Hair Cell ◽  
Outer Hair Cell Motility

Effect of turgor pressure on outer hair cell motility

2000 ◽  
Vol 108 (5) ◽  
pp. 2299-2306 ◽  
Author(s):  
M. Adachi ◽  
M. Sugawara ◽  
K. H. Iwasa
Keyword(s):  
Hair Cell ◽  
Cell Motility ◽  
Outer Hair Cell ◽  
Turgor Pressure ◽  
Outer Hair Cell Motility

Passive compliance and active force generation in the guinea pig outer hair cell

1995 ◽  
Vol 74 (6) ◽  
pp. 2319-2328 ◽  
Author(s):  
R. Hallworth
Keyword(s):  
Hair Cell ◽  
Cell Motility ◽  
Hair Cells ◽  
Outer Hair Cell ◽  
Outer Hair Cells ◽  
Force Generation ◽  
Axial Stiffness ◽  
Sinusoidal Voltage ◽  
Apparent Stiffness ◽  
Outer Hair Cell Motility

1. Cochlear outer hair cells 20-80 microns in length were compressed axially in vitro using calibrated glass fibers mounted on a piezoelectric actuator. 2. When driven by rectangular pulses in the compression direction, the motion of the fiber tip consisted of a rapid initial compression that was complete in 10-20 ms followed by a smaller compression of slower time course. 3. The initial fiber deflections were found to be linear in amplitude for compressions up to 400 nm. The axial compliances of outer hair cells were calculated from the difference between the fiber tip motions when unattached and when in contact with a cell. Axial compliances were found to be in the range of 0.04-1.2 km/N for 149 cells. The axial compliance was an increasing function of cell length. 4. The peak forces generated by electrically stimulated outer hair cells were measured from the deflection of a glass fiber when the cells were stimulated by sinusoidal voltage commands. The slope gains of force generation (force generated per mV of command at the cell membrane) were estimated to range from 0.01 to 100 pN/mV. Most of the results fell in the range of 0.1-20 pN/mV. 5. When the apparent stiffness of the fiber was increased by moving the cell closer to the fiber base, the peak amplitude of the fiber deflection generated by the cell decreased and the peak force increased, for the same sinusoidal voltage command. 6. The results of the previous experiment were interpreted in the light of a model of outer hair cell motility in which an ideal extension generating element is in series with an internal stiffness element. This internal stiffness was then calculated for 13 cells. 7. The internal stiffnesses of cells calculated by the above procedure were found to be positively correlated with the axial stiffness measurements obtained for the same cells. 8. The implications of the above results for the effectiveness of outer hair cell motility in vivo are discussed.

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