Thorn-shaped astrocytes: possibly secondarily induced tau-positive glial fibrillary tangles

1995 ◽  
Vol 90 (6) ◽  
pp. 620-625 ◽  
Author(s):  
K. Ikeda ◽  
H. Akiyama ◽  
H. Kondo ◽  
C. Haga ◽  
E. Tanno ◽  
...  
Keyword(s):  
Glial Fibrillary Tangles

499. Glial fibrillary tangles in patients with late onset schizophrenia

2000 ◽  
Vol 47 (8) ◽  
pp. S152 ◽  
Author(s):  
M.F. Casanova ◽  
J.R. Stevens ◽  
R. Brown ◽  
C. Royston ◽  
C. Bruton
Keyword(s):  
Late Onset ◽  
Glial Fibrillary Tangles

Numerous glial fibrillary tangles in oligodendroglia in cases of subacute sclerosing panencephalitis with neurofibrillary tangles

1995 ◽  
Vol 194 (1-2) ◽  
pp. 133-135 ◽  
Author(s):  
Kenji Iked ◽  
Haruhiko Akiyama ◽  
Hiromi Kondo ◽  
Tetsuaki Arai ◽  
Nobutaka Arai ◽  
...  
Keyword(s):  
Neurofibrillary Tangles ◽  
Subacute Sclerosing Panencephalitis ◽  
Glial Fibrillary Tangles

Thorn-shaped astrocytes: possibly secondarily induced tau-positive glial fibrillary tangles

1995 ◽  
Vol 90 (6) ◽  
pp. 620-625 ◽  
Author(s):  
K. Ikeda ◽  
H. Akiyama ◽  
H. Kondo ◽  
C. Haga ◽  
E. Tanno ◽  
...  
Keyword(s):  
Glial Fibrillary Tangles

Glial fibrillary tangles and argyrophilic threads: Classification and disease specificity

1996 ◽  
Vol 16 (1) ◽  
pp. 71-77 ◽  
Author(s):  
Kenji Ikeda
Keyword(s):  
Glial Fibrillary Tangles ◽  
Disease Specificity

scholarly journals Neuropathology of SCA34 showing widespread oligodendroglial pathology with vacuolar white matter degeneration: a case study

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Kokoro Ozaki ◽  
Takashi Irioka ◽  
Toshiki Uchihara ◽  
Akane Yamada ◽  
Ayako Nakamura ◽  
...  
Keyword(s):  
White Matter ◽  
Spinocerebellar Ataxia ◽  
Periodic Acid ◽  
Neuronal Loss ◽  
Spinocerebellar Ataxia Type ◽  
Gene Encoding ◽  
Periodic Acid Schiff ◽  
Positive Material ◽  
Glial Fibrillary Tangles ◽  
Macroscopic Findings

AbstractSpinocerebellar ataxia type 34 (SCA34) is an autosomal dominant inherited ataxia due to mutations in ELOVL4, which encodes one of the very long-chain fatty acid elongases. SCA38, another spinocerebellar ataxia, is caused by mutations in ELOVL5, a gene encoding another elongase. However, there have been no previous studies describing the neuropathology of either SCA34 or 38. This report describes the neuropathological findings of an 83-year-old man with SCA34 carrying a pathological ELOVL4 mutation (NM_022726, c.736T>G, p.W246G). Macroscopic findings include atrophies in the pontine base, cerebellum, and cerebral cortices. Microscopically, marked neuronal and pontocerebellar fiber loss was observed in the pontine base. In addition, in the pontine base, accumulation of CD68-positive macrophages laden with periodic acid-Schiff (PAS)-positive material was observed. Many vacuolar lesions were found in the white matter of the cerebral hemispheres and, to a lesser extent, in the brainstem and spinal cord white matter. Immunohistological examination and ultrastructural observations with an electron microscope suggest that these vacuolar lesions are remnants of degenerated oligodendrocytes. Electron microscopy also revealed myelin sheath destruction. Unexpectedly, aggregation of the four-repeat tau was observed in a spatial pattern reminiscent of progressive supranuclear palsy. The tau lesions included glial fibrillary tangles resembling tuft-shaped astrocytes and neurofibrillary tangles and pretangles. This is the first report to illustrate that a heterozygous missense mutation in ELOVL4 leads to neuronal loss accompanied by macrophages laden with PAS-positive material in the pontine base and oligodendroglial degeneration leading to widespread vacuoles in the white matter in SCA34.

774 Twisted profile of glial fibrillary tangles in the astrocytic process in brains with Alzheimer-type dementia

1996 ◽  
Vol 17 (4) ◽  
pp. S192
Author(s):  
K. Arima ◽  
Y. Izumiyama ◽  
M. Nakamura
Keyword(s):  
Alzheimer Type ◽  
Astrocytic Process ◽  
Alzheimer Type Dementia ◽  
Glial Fibrillary Tangles

Anti-tau-positive glial fibrillary tangles in the brain of postencephalitic parkinsonism of Economo type

1993 ◽  
Vol 162 (1-2) ◽  
pp. 176-178 ◽  
Author(s):  
Kenji Ikeda ◽  
Haruhiko Akiyama ◽  
Hiromi Kondo ◽  
Kazuhiko Ikeda
Keyword(s):  
Postencephalitic Parkinsonism ◽  
Glial Fibrillary Tangles ◽  
The Brain

P3-368 Neuronal and glial fibrillary tangles in parkinsonism dementia of Guam are more extensive and severe than in Alzheimer disease and other tauopathies

2004 ◽  
Vol 25 ◽  
pp. S460
Author(s):  
Judit Miklossy ◽  
Tetsu Arai ◽  
Claudia Schwab ◽  
John C. Steele ◽  
Patrick L. McGeer
Keyword(s):  
Alzheimer Disease ◽  
Glial Fibrillary Tangles

Glial fibrillary tangles in diffuse neurofibrillary tangles with calcification

2003 ◽  
Vol 106 (2) ◽  
pp. 150-156 ◽  
Author(s):  
Naoki Hashimoto ◽  
Tohru Takeuchi ◽  
Ryoko Ishihara ◽  
Katsuyuki Ukai ◽  
Hiroshi Kobayashi ◽  
...  
Keyword(s):  
Neurofibrillary Tangles ◽  
Glial Fibrillary Tangles
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