BT-Paba test in the diagnosis of pancreatic exocrine insufficiency in cystic fibrosis: urinary and serum determinations compared

1984 ◽  
Vol 143 (2) ◽  
pp. 145-148 ◽  
Author(s):  
S. Bellentani ◽  
A. Grisendi ◽  
M. Rinaldi ◽  
P. Bertolani ◽  
G. Costa ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pancreatic Exocrine Insufficiency ◽  
Exocrine Insufficiency ◽  
Pancreatic Exocrine

Efficacy and Tolerability of Creon for Children in Infants and Toddlers With Pancreatic Exocrine Insufficiency Caused by Cystic Fibrosis

Pancreas ◽  
2009 ◽  
Vol 38 (6) ◽  
pp. 693-699 ◽  
Author(s):  
Carla Colombo ◽  
Clara Fredella ◽  
Maria Chiara Russo ◽  
Nadia Faelli ◽  
Valentina Motta ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Infants And Toddlers ◽  
Pancreatic Exocrine Insufficiency ◽  
Exocrine Insufficiency ◽  
Pancreatic Exocrine

Bioavailability of food iron-(59Fe), vitamin B12-(60Co) and protein bound selenomethionine-(75Se) in pancreatic exocrine insufficiency due to cystic fibrosis

1977 ◽  
Vol 55 (12) ◽  
pp. 595-601 ◽  
Author(s):  
H. C. Heinrich ◽  
E. E. Gabbe ◽  
H. Bartels ◽  
K. H. Oppitz ◽  
Ch Bender-G�tze ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin B12 ◽  
Pancreatic Exocrine Insufficiency ◽  
Exocrine Insufficiency ◽  
Pancreatic Exocrine

Comparison of two enteric coated microsphere preparations in the treatment of pancreatic exocrine insufficiency caused by cystic fibrosis

2000 ◽  
Vol 32 (5) ◽  
pp. 406-411 ◽  
Author(s):  
B. Santini ◽  
M. Antonelli ◽  
A. Battistini ◽  
S. Bertasi ◽  
M. Collura ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pancreatic Exocrine Insufficiency ◽  
Exocrine Insufficiency ◽  
Pancreatic Exocrine ◽  
Enteric Coated

Treatment of Pancreatic Exocrine Insufficiency with Enteric Coated Pancreatin Formulations: An Overview

2013 ◽  
Vol 6 (3) ◽  
pp. 2125-2130
Author(s):  
B K Bhattacharyya ◽  
S Chowdhury ◽  
S Das ◽  
S Mukherjee ◽  
D Bhattacharjee
Keyword(s):  
Cystic Fibrosis ◽  
Digestive Enzymes ◽  
Pancreatic Insufficiency ◽  
Pancreatic Enzyme ◽  
Pancreatic Exocrine Insufficiency ◽  
Exocrine Insufficiency ◽  
Enzyme Replacement ◽  
Increased Risk ◽  
Pancreatic Exocrine ◽  
Enteric Coated

Pancreatin is a mixture of several digestive enzymes produced by the exocrine cells of the pancreas. It is composed of amylase, lipase and protease. It is used to treat conditions in which pancreatic secretions are deficient, such as surgical pancreatectomy, pancreatitis and cystic fibrosis. Pancreatin products contain the pancreatic enzymes trypsin, amylase and lipase. The patients with pancreatic diseases often suffer from pancreatic exocrine insufficiency. In such condition pancreas does not secrete required amount of digestive enzymes for proper digestion to occur. Severe pancreatic insufficiency occurs in cystic fibrosis, chronic pancreatitis, tumors or after surgical resection. Thus pancreatic exocrine insufficiency may result in clinical manifestation of malnutrition, weight loss and steatorrhea leading towards the increased risk of morbidity and mortality. For the improvement of clinical symptoms, restriction of fat intake and pancreatic enzyme replacement therapy are recommended. The enzyme substitution therapy is very much challenging because the optimal enzyme dose is highly variable to mimic the physiological pattern of pancreatic exocrine secretion. Regulatory authorities have approved several pancreatic enzyme formulations in the form of enteric coated minimicrosphere which are now available commercially. This review focuses on the physiological considerations of   pancreatic exocrine insufficiency and its treatment with enteric coated pancreatin formulations. 

Sign in / Sign up

Export Citation Format

Share Document