Type II Collagen induced bone resorption in the temporal bone of rats: Histological and immunohistochemical studies

1985 ◽  
Vol 242 (2) ◽  
pp. 183-188 ◽  
Author(s):  
Cheng -Chun Huang ◽  
Diego Saporta ◽  
Maxwell Abramson
Keyword(s):  
Bone Resorption ◽  
Temporal Bone ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Immunohistochemical Studies

Type II collagen and TGF-βs in developing and aging porcine mandibular condylar cartilage: immunohistochemical studies

1997 ◽  
Vol 289 (1) ◽  
pp. 119-124 ◽  
Author(s):  
J. R. Moroco ◽  
R. Hinton ◽  
P. Buschang ◽  
S. B. Milam ◽  
A. M. Iacopino
Keyword(s):  
Type Ii Collagen ◽  
Type Ii ◽  
Condylar Cartilage ◽  
Mandibular Condylar Cartilage ◽  
Immunohistochemical Studies

Type II Collagen-Induced Autoimmune Otospongiosis

1983 ◽  
Vol 92 (2) ◽  
pp. 103-108 ◽  
Author(s):  
T. J. Yoo ◽  
K. Tomoda ◽  
A. H. Kang ◽  
J. M. Stuart ◽  
A. S. Townes
Keyword(s):  
Bone Resorption ◽  
Bone Formation ◽  
Bone Matrix ◽  
Type Ii Collagen ◽  
Antibody Responses ◽  
Type Ii ◽  
New Bone Formation ◽  
Chemical Alteration ◽  
Immunofluorescence Studies ◽  
Dark Staining

Otospongiosis-like lesions were induced in rats by immunizing them with native type II collagen. Immunized rats had antibody responses specific for native type II collagen and developed otospongiosis-like lesions. The spongiotic lesion was characterized by numerous osteocytes and osteoblasts in the vascular spaces and by dark staining probably due to the chemical alteration of ground substances. Bone resorption and new bone formation were clearly visible. Immunofluorescence studies demonstrated deposition of immunoglobulin and complement on the bone matrix and wall within the area of spongiosis. An antibody-mediated etiopathogenesis was suspected.

Disturbed Synthesis of Type II Collagen Interferes with Rate of Bone Formation and Growth and Increases Bone Resorption in Transgenic Mice

2008 ◽  
Vol 82 (3) ◽  
pp. 229-237 ◽  
Author(s):  
Jyrki Nieminen ◽  
Janne Sahlman ◽  
Teemu Hirvonen ◽  
Tuomo Lapveteläinen ◽  
Markku Miettinen ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Bone Formation ◽  
Transgenic Mice ◽  
Type Ii Collagen ◽  
Type Ii

scholarly journals The type II collagen N-propeptide, PIIBNP, inhibits cell survival and bone resorption of osteoclasts via integrin-mediated signaling

Bone ◽  
2011 ◽  
Vol 49 (4) ◽  
pp. 644-652 ◽  
Author(s):  
Shinya Hayashi ◽  
Zhepeng Wang ◽  
Jennifer Bryan ◽  
Chikashi Kobayashi ◽  
Roberta Faccio ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Cell Survival ◽  
Type Ii Collagen ◽  
Type Ii

Stimulatory effect of bacteria or IL-12 on the reaction to type II collagen in mice

1997 ◽  
Vol 56 (1-3) ◽  
pp. 414
Author(s):  
J Szeliga
Keyword(s):  
Type Ii Collagen ◽  
Type Ii

Healing of Circular Defects in the Rabbit Medial Meniscus Can Occur Spontaneously and Is not Improved by Intra-Articular Hyaluronic Acid

1996 ◽  
Vol 09 (02) ◽  
pp. 60-5 ◽  
Author(s):  
N. Hope ◽  
P. Ghosh ◽  
S. Collier
Keyword(s):  
Hyaluronic Acid ◽  
Medial Meniscus ◽  
Chondroitin Sulphate ◽  
Rabbit Model ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Keratan Sulphate ◽  
Meniscal Healing ◽  
Meniscus Healing ◽  
Made In

SummaryThe aim of this study was to determine the effects of intra-articular hyaluronic acid on meniscal healing. Circular defects, 1.0 mm in diameter, were made in the anterior third of the medial meniscus in rabbits. In one joint, 0.4 ml hyaluronic acid (Healon®) was instilled, and in the contralateral (control) joint, 0.4 ml Ringer’s saline. Four rabbits were killed after four, eight and 12 weeks and the menisci examined histologically. By eight weeks most of the lesions had healed by filling with hyaline-like cartilage. Healing was not improved by hyaluronic acid treatment. The repair tissue stained strongly with alcian blue, and the presence of type II collagen, keratan sulphate, and chondroitin sulphate was demonstrated by immunohistochemical localisation. In contrast to the circular defects, longitudinal incisions made in the medial menisci of a further six rabbits did not show any healing after 12 weeks, indicating that the shape of the lesion largely determined the potential for healing.The effect of hyaluronic acid on meniscal healing was tested in a rabbit model. With one millimeter circular lesions in the medial meniscus, healing by filling with hyalinelike cartilage was not significantly affected by the application of hyaluronic acid intra-articularly at the time of surgery, compared to saline controls, as assessed histologically four, eight and 12 weeks after the operation.

PART III. AutoimmunityAn Altered Peptide Ligand of Type II Collagen Suppresses Autoimmune Arthritis

2007 ◽  
Vol 27 (4) ◽  
pp. 345-356 ◽  
Author(s):  
Linda K. Myers ◽  
Bo Tang ◽  
Edward F. Rosioniec ◽  
John M. Stuart ◽  
Andrew H. Kang
Keyword(s):  
Type Ii Collagen ◽  
Peptide Ligand ◽  
Autoimmune Arthritis ◽  
Altered Peptide Ligand ◽  
Type Ii
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