End-plate currents evoked by paired stimuli in frog muscle fibres

1984 ◽  
Vol 401 (2) ◽  
pp. 185-192 ◽  
Author(s):  
L. G. Magazanik ◽  
E. E. Nikolsky ◽  
R. A. Giniatullin

Injection of acetylcholine receptors from the electric organ of Torpedo into rabbits or rats, produces antibodies which bind to acetylcholine receptors in the muscle membrane or in solution. Binding of antibody to the receptors results in diminished acetylcholine sensitivity of the muscle fibres, reduced amplitude of miniature end-plate potentials, block of neuromuscular transmission and a decrease in the ability of the receptors to bind a -bungarotoxin. Antibodies raised against acetylcholine receptors from Torpedo cross-react with acetylcholine receptors from rabbit, rat and frog muscle.



1966 ◽  
Vol 183 (1) ◽  
pp. 152-166 ◽  
Author(s):  
B. Frankenhaeuser ◽  
B. D. Lindley ◽  
R. S. Smith




In the frog muscle, ext. long. dig. IV, there are two or three spindle systems. Each consists of a bundle of intrafusal muscle fibres with two, three or four discrete encapsulated sensory regions distributed in mechanical series along it. A sensory region is usually comprised of the coiled branches of one afferent axon. These embrace the intrafusal fibres and ultimately form long fine varicose endings on or near them. The intrafusal striations appear to be lost for a short distance within the sensory region, and in this region the intrafusal fibre nuclei crowd together. The ‘small’ extrafusal efferents break up into trusses of fine unmyelinated axons and terminate as ‘grape’ end-plates, several of which can occur on the same muscle fibre. This is the ‘tonic’ system. The ‘large’ extrafusal efferents terminate as ‘Endbiischel’ end-plates on muscle fibres not supplied by grape endings. This is the ‘twitch’ system. Both ‘grape' and ‘twitch’ end-plates occur on the intrafusal bundle (probably on separate fibres) between the sensory regions. They are supplied by branches of ‘small’ or ‘large’ axons respectively, which also innervate extrafusal fibres. Thus like the extrafusals the intrafusal bundle is composed of ‘tonic’ and ‘twitch’ muscle fibres. This situation contrasts with that of the mammal, where extrafusals are exclusively ‘twitch’ fibres and intrafusals ‘tonic’.



1993 ◽  
Vol 468 (1) ◽  
pp. 543-556 ◽  
Author(s):  
C J Barclay ◽  
N A Curtin ◽  
R C Woledge


2006 ◽  
Vol 578 (1) ◽  
pp. 337-346 ◽  
Author(s):  
Barbara Colombini ◽  
Maria Angela Bagni ◽  
Giovanni Cecchi ◽  
Peter John Griffiths
Keyword(s):  


Nature ◽  
1965 ◽  
Vol 206 (4984) ◽  
pp. 629-630 ◽  
Author(s):  
G. ROSSI ◽  
G. CORTESINA


2007 ◽  
Vol 585 (2) ◽  
pp. 607-615 ◽  
Author(s):  
Barbara Colombini ◽  
Marta Nocella ◽  
Giulia Benelli ◽  
Giovanni Cecchi ◽  
Maria Angela Bagni


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