Modeling and Calibration for Dithering of MDRLG and Time-Delay of Accelerometer in SINS

At present, the design and manufacturing technology of mechanically dithered ring laser gyroscope (MDRLG) have matured, the strapdown inertial navigation systems (SINS) with MDRLG have been widely used in military and business scope. When the MDRLG is working, high-frequency dithering is introduced, which will cause the size effect error of the accelerometer. The accelerometer signal has a time delay relative to the system, which will cause the accelerometer time delay error. In this article, in order to solve the above-mentioned problem: (1) we model the size effect error of the mechanically dithering of the MDRLG and perform an error analysis for the size effect error of the mechanically dithering of the MDRLG; (2) we model the time delay error of accelerometer and perform an error analysis for the time delay error of accelerometer; (3) we derive a continuous linear 43-D SINS error model considering the above-mentioned two error parameters and expand the temperature coefficients of accelerometers, inner lever arm error, outer lever arm error parameters to achieve high-precision calibration of SINS. We use the piecewise linear constant system (PWCS ) method during the calibration process to prove that all calibration parameters are observable. Finally, the SINS with MDRLG is used in laboratory conditions to test the validity of the calibration method.

Investigation of the molecular motor of muscle: from generating life in a test tube to myosin structure over beers

This article traces 60 years of investigation of the molecular motor of skeletal muscle from the 1940s through the 1990s. It started with the discovery that myosin interaction with actin in the presence of ATP caused shortening of threads of actin and myosin. In 1957, structures protruding from myosin filaments were seen for the first time and called “cross bridges.” A combination of techniques led to the proposal in 1969 of the “swinging-tilting cross bridge” model of contraction. In the early 1980s, a major problem arose when it was shown that a probe attached to the cross bridges did not move during contraction. A spectacular breakthrough came when it was discovered that only the cross bridge was required to support movement in an in vitro motility assay. Next it was determined that single myosin molecules caused the movement of actin filaments in 10-nm steps. The atomic structure of the cross bridge was published in 1993, and this discovery supercharged the muscle field. The cross bridge contained a globular head or motor domain that bound actin and ATP. But the most striking feature was the long tail of the cross bridge surrounded by two subunits of the myosin molecule. This structure suggested that the tail might act as a lever arm magnifying head movement. Consistent with this proposal, genetic techniques that lengthened the lever arm resulted in larger myosin steps. Thus the molecular motor of muscle operated not by the tilting of the globular head of myosin but by tilting of the lever arm generating the driving force for contraction.

The New 1 kN·m Torque Standard Machine in National Institute of Metrology, China

A 1 kN-m deadweight torque standard machine is established in National Institute of Metrology, China. The torque range is 5N·m-1200 N·m. The deadweights utilized in the machine can generate the torque of 1200 N·m, 600N·m, 360N·m, 240N·m, 120N·m and 60 N·m, respectively. The torque can be applied both in clock-wise and counter clock-wise direction in sequencial loading process. The aerostatic bearing is introduced to the torque standard machine in order to eliminate the influence of friction. The symmetric V type rotor and stator are used to provide the reliable support both in axial and radial direction. The material of the lever arm is invar alloy, performing with the minimum deformation with the change of the ambient temperature. The counter torque part will make the precise adjustment to make a horizontal alignment of the lever arm. The relative standard uncertainty of the torque generated by the machine is less than 1e-5.

Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function

ABSTRACTMutations in the lever arm of β-cardiac myosin are a frequent cause of hypertrophic cardiomyopathy (HCM), a disease characterized by hypercontractility and eventual hypertrophy of the left ventricle. Here, we studied five such mutations: three in the pliant region of the lever arm (D778V, L781P, and S782N) and two in the light chain-binding region (A797T and F834L). We investigated their effects on both motor function and myosin S2 tail-based autoinhibition. The pliant region mutations had varying effects on the motor function of a myosin construct lacking the S2 tail: overall, D778V increased power output, L781P reduced power output, and S782N had little effect on power output, while all three reduced the external force sensitivity of the actin detachment rate. With a myosin containing the motor domain and the proximal S2 tail, the pliant region mutations also attenuated autoinhibition in the presence of filamentous actin but had no impact in the absence of actin. By contrast, the light chain-binding region mutations had little effect on motor activity but produced marked reductions in autoinhibition in both the presence and absence of actin. Thus, mutations in the lever arm of β-cardiac myosin have divergent allosteric effects on myosin function, depending on whether they are in the pliant or light chain-binding regions.

Treatment of Unstable Sacral Fracture with Minimally Invasive Spinopelvic Posterior Fixation and an Internal Anterior Fixator in a 95-Year-Old Patient with Diffuse Idiopathic Skeletal Hyperostosis: A Case Report

Introduction:Spinal fractures related to diffuse idiopathic skeletal hyperostosis (DISH) are almost always caused by a long lever arm, so treatment of the fractures requires stabilization of long segments of the spine. Treatment of unstable sacral fractures in DISH patients with ankylosis of the sacroiliac joints requires a treatment strategy that includes a consideration of the condition of the spine. This article is the first report of an unstable sacral fracture in a patient with DISH. Case Report:A 95-year-old male fell and presented with severe low back pain. An X-ray and computed tomography showed unstable pelvic fracture (AO type C2) and ankylosis of the lumbar spine due to DISH. We performed minimally invasive spinopelvic posterior fixation and internal anterior fixation (INFIX) for stabilization of the pelvic fracture. Initially, due to the long lever arm created from the lumbar spine to the pelvis, we performed L2-iliac posterior stabilization while the patient was in a prone position. After that, we performed INFIX to stabilize the anterior pelvis while the patient was positioned supine. The postoperative clinical course of the patient was uneventful and bony fusion was achieved as seen on X-ray obtained 1 year postoperatively. Conclusion:This patient was ankylosed from spine to pelvis due to DISH and sacroiliac joint ankylosis and sustained bilateral sacral fractures which dissociated the sacrum from the rest of the pelvis. Therefore, this fracture required spinopelvic fixation from the ankylosing spine to the pelvis. Because this patient was so elderly and in poor general health, we performed minimally invasive spinopelvic posterior fixation using percutaneous pedicle screws. We considered that many screw insertions that would equivalently stabilize the spine several segments above and below the fracture would be needed to stabilize the sacral fractures in this patient with DISH. In this case, we stabilized the unstable right pelvis, in a patient with

Empennage sizing with the tail volume complemented with a method for dorsal fin layout

Purpose: Provide good values for the tail volume coefficient and the lever arm as a percentage of the fuselage length. Provide a statistical method for dorsal fin layout. – Methodology: Based on an understanding of flight physics, the statistical correlation of real aircraft parameters is investigated. This is based on the firm conviction that high fidelity parameters for future aircraft need a checked against parameters of existing successful aircraft. – Findings: Typical tail volume coefficients are between 0.5 and 1.0 for the horizontal tail and between 0.03 and 0.08 for the vertical tail depending on aircraft category. Empennage statistics have clear trends. The often weak correlation shows that aircraft design allows for sufficient designer's choice. Only a minority of aircraft feature a dorsal fin. Designers see it as an added surface rather than as part of the vertical tail. It is used to limit the hypothetical risk of vertical tail stall due to high sideslip angles. – Research Limitations: Results obtained from statistics are close to reality, but not a proof to fulfill requirements. – Practical Implications: Methods from the paper can be used for quick initial sizing of a vertical tail with or without dorsal fin or sizing of a horizontal tail. These results can also be used as good starting values for optimization tools in aircraft design. – Originality: Estimation of the tail lever arm is necessary for sizing with the tail volume coefficient, but had not been investigated to any detail. A method for the layout of dorsal fins was missing.

The Synergic Role of Actomyosin Architecture and Biased Detachment in Muscle Energetics: Insights in Cross Bridge Mechanism Beyond the Lever-Arm Swing

Muscle energetics reflects the ability of myosin motors to convert chemical energy into mechanical energy. How this process takes place remains one of the most elusive questions in the field. Here, we combined experimental measurements of in vitro sliding velocity based on DNA-origami built filaments carrying myosins with different lever arm length and Monte Carlo simulations based on a model which accounts for three basic components: (i) the geometrical hindrance, (ii) the mechano-sensing mechanism, and (iii) the biased kinetics for stretched or compressed motors. The model simulations showed that the geometrical hindrance due to acto-myosin spatial mismatching and the preferential detachment of compressed motors are synergic in generating the rapid increase in the ATP-ase rate from isometric to moderate velocities of contraction, thus acting as an energy-conservation strategy in muscle contraction. The velocity measurements on a DNA-origami filament that preserves the motors’ distribution showed that geometrical hindrance and biased detachment generate a non-zero sliding velocity even without rotation of the myosin lever-arm, which is widely recognized as the basic event in muscle contraction. Because biased detachment is a mechanism for the rectification of thermal fluctuations, in the Brownian-ratchet framework, we predict that it requires a non-negligible amount of energy to preserve the second law of thermodynamics. Taken together, our theoretical and experimental results elucidate less considered components in the chemo-mechanical energy transduction in muscle.

Design and Development of Forklift

In this research work, the Forklift was carried out. The forklift has the following parts, base plate, battery, vertical column, horizontal arm, roller, hook, nuts and bolts, crank plate, lever arm and DC motors. It was designed for load of 50 to 100 kg capacities and the development of suitable system configuration having movable wheel attached base. The performance of this forklift was satisfactory and can be used in the laboratory and industry.

Short lever arm, bipedicular handlebar construct for correction of acute angular kyphosis in spondylodiscitis-induced kyphotic deformity: illustrative case

BACKGROUND Pyogenic spondylodiscitis diminishes spinal structural integrity via disruption of the anterior and middle column, sometimes further compounded by iatrogenic violation of the posterior tension band during initial posterior decompressive surgeries. Although medical management is typically sufficient, refractory infection or progressive deformity may require aggressive debridement and reconstructive arthrodesis. Although anterior debridement plus reconstruction with posterior stabilization is an effective treatment option, existing techniques have limited efficacy for correcting focal deformity, leaving patients at risk for long-term sagittal imbalance, pain, and disability. OBSERVATIONS The authors present a case of chronic lumbar pyogenic spondylodiscitis in a patient in whom initial surgical debridement failed and pronounced angular kyphosis and intractable low back pain developed. A novel bipedicular handlebar construct was used to achieve angular correction of the kyphosis through simultaneous anterior interbody grafting and posterior instrumentation with the patient in the lateral position. LESSONS Leveraging both pedicle screws at the same level to transmit controlled corrective distraction forces through the segment allows for kyphosis correction without relying on long posterior constructs for cantilever reduction. Simultaneous anterior reconstruction with a posterior short lever arm, bipedicular handlebar construct is an effective technique for achieving high angular correction during circumferential reconstructive approaches to postinfectious focal kyphotic deformities.