A double-blind and cross-over comparison of once daily doxazosin and placebo with steady-state pharmacokinetics in elderly hypertensive patients

1988 ◽  
Vol 34 (2) ◽  
pp. 119-123 ◽  
Author(s):  
P. J. W. Scott ◽  
J. Hosie ◽  
M. G. B. Scott
Keyword(s):  
Steady State ◽  
Double Blind ◽  
Once Daily ◽  
Hypertensive Patients ◽  
Elderly Hypertensive ◽  
Elderly Hypertensive Patients

Comparison of a Long-Acting Form of Propranolol and Conventional Propranolol in the Treatment of Hypertension in Elderly Patients

1987 ◽  
Vol 15 (3) ◽  
pp. 128-133
Author(s):  
A. U. Khan
Keyword(s):  
Elderly Patients ◽  
Second Line ◽  
Double Blind ◽  
Once Daily ◽  
Hypertensive Patients ◽  
Treatment Of Hypertension ◽  
Blood Pressures ◽  
Elderly Hypertensive ◽  
Elderly Hypertensive Patients ◽  
Long Acting

Nineteen elderly hypertensive patients already being treated with a diuretic and, where necessary, another anti-hypertensive agent, were studied in a double-blind, randomized, crossover comparison of conventional propranolol, 40 mg three times daily, with a long-acting propranolol formulation, 160 mg once daily, as a second line agent. Patients were assessed before taking the morning's allocated medication. This was done as near as possible to 24 h after the last dose of once daily propranolol and as near as possible to 15 h after the last dose of three times daily conventional propranolol. Assessment was carried out at the time of randomization and after 4 weeks' treatment with both propranolol formulations. Heart rate and blood pressures were measured in the supine and standing positions and after exercise. Both propranolol formulations were effective as second line agents in these elderly patients and both were well tolerated. Patient compliance on both propranolol formulations was very good although the long-acting formulation may be of value in improving this still further.

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