Characterization of organ-specific immunoliposomes for delivery of 3′,5′-O-dipalmitoyl-5-fluoro-2′-deoxyuridine in a mouse lung-metastasis model

1995 ◽  
Vol 35 (6) ◽  
pp. 447-456 ◽  
Author(s):  
Atsuhide Mori ◽  
Stephen J. Kennel ◽  
Marjan van Borssum Waalkes ◽  
Gerrit L. Scherphof ◽  
Leaf Huang
Keyword(s):  
Lung Metastasis ◽  
Mouse Lung ◽  
Organ Specific ◽  
Metastasis Model

Characterization of organ-specific immunoliposomes for delivery of 3?,5?-O-dipalmitoyl-5-fluoro-2?-deoxyuridine in a mouse lung-metastasis model

1995 ◽  
Vol 35 (6) ◽  
pp. 447-456
Author(s):  
Atsuhide Mori ◽  
Stephen J. Kennel ◽  
Marjan Borssum Waalkes ◽  
Gerrit L. Scherphof ◽  
L. Huang
Keyword(s):  
Lung Metastasis ◽  
Mouse Lung ◽  
Organ Specific ◽  
Metastasis Model

scholarly journals Anti-metastatic effect of the TM4SF5-specific peptide vaccine and humanized monoclonal antibody on colon cancer in a mouse lung metastasis model

Oncotarget ◽  
2016 ◽  
Vol 7 (48) ◽  
pp. 79170-79186 ◽  
Author(s):  
Guang Wu ◽  
Dongbum Kim ◽  
Byoung Kwon Park ◽  
Sangkyu Park ◽  
Ji-Hee Ha ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Colon Cancer ◽  
Lung Metastasis ◽  
Peptide Vaccine ◽  
Mouse Lung ◽  
Humanized Monoclonal Antibody ◽  
Metastasis Model ◽  
Specific Peptide

Abstract 4309: Whole slide image analysis quantification in a mouse lung metastasis model

2014 ◽  
Author(s):  
George E. Sandusky ◽  
Ronne Surface ◽  
Eva Tonsing-Carter ◽  
jayne Silver ◽  
Tony Sinn ◽  
...  
Keyword(s):  
Image Analysis ◽  
Lung Metastasis ◽  
Mouse Lung ◽  
Whole Slide Image ◽  
Slide Image ◽  
Metastasis Model

Exchanging human Fcγ1 with murine Fcγ2a highly potentiates anti-tumor activity of anti-EpCAM antibody adecatumumab in a syngeneic mouse lung metastasis model

2006 ◽  
Vol 56 (4) ◽  
pp. 459-468 ◽  
Author(s):  
Petra Lutterbuese ◽  
Klaus Brischwein ◽  
Robert Hofmeister ◽  
Sandrine Crommer ◽  
Grit Lorenczewski ◽  
...  
Keyword(s):  
Lung Metastasis ◽  
Mouse Lung ◽  
Syngeneic Mouse ◽  
Metastasis Model ◽  
Anti Tumor Activity

Characterization of a gadolinium-labeled cholesterol derivative as an organ-specific contrast agent for adrenal MR imaging

1995 ◽  
Vol 5 (1) ◽  
pp. 7-10 ◽  
Author(s):  
Andreas Muhler ◽  
Johannes Platzek ◽  
Bernd Radüchel ◽  
Thomas Frenzel ◽  
Hanns-Joachim Weinmann
Keyword(s):  
Mr Imaging ◽  
Contrast Agent ◽  
Organ Specific ◽  
Cholesterol Derivative ◽  
Adrenal Mr

scholarly journals β-Lapachone Inhibits Lung Metastasis of Colorectal Cancer by Inducing Apoptosis of CT26 Cells

2016 ◽  
Vol 16 (4) ◽  
pp. 585-596 ◽  
Author(s):  
Ji-Ye Kee ◽  
Yo-Han Han ◽  
Jinbong Park ◽  
Dae-Seung Kim ◽  
Jeong-Geon Mun ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Lung Metastasis ◽  
Cancer Cell Lines ◽  
Colon Cancer Cell ◽  
Experimental Metastasis ◽  
Colon Cancer Cell Lines ◽  
Metastasis Model

Background: β-Lapachone is a quinone-containing compound found in red lapacho ( Tabebuia impetiginosa, syn. T avellanedae) trees. Lapacho has been used in traditional medicine by several South and Central American indigenous people to treat various types of cancer. The purpose of this study was to investigate the antimetastatic properties of β-lapachone and the underlying mechanisms using colon cancer cells. Methods: This research used metastatic murine colon cancer cell lines, colon 26 (CT26) and colon 38 (MC38). A WST assay, annexin V assay, cell cycle analysis, wound healing assay, invasion assay, western blot analysis, and real-time reverse transcription–polymerase chain reaction were performed to examine the effects of β-lapachone on metastatic phenotypes and molecular mechanisms. The effect of β-lapachone on lung metastasis was assessed in a mouse experimental metastasis model. Results: We found that the inhibition of proliferation of the colon cancer cell lines by β-lapachone was due to the induction of apoptosis and cell cycle arrest. β-Lapachone induced the apoptosis of CT26 cells through caspase-3, -8, and -9 activation; poly(ADP-ribose) polymerase cleavage; and downregulation of the Bcl-2 family in a dose- and time-dependent manner. In addition, a low concentration of β-lapachone decreased the cell migration and invasion by decreasing the expression of matrix metalloproteinases-2 and -9, and increased the expression of tissue inhibitors of metalloproteinases-1 and -2. Moreover, β-lapachone treatment regulated the expression of epithelial-mesenchymal transition markers such as E- and N-cadherin, vimentin, β-catenin, and Snail in CT26 cells. In the mouse experimental metastasis model, β-lapachone significantly inhibited the lung metastasis of CT26 cells. Conclusions: Our results demonstrated the inhibitory effect of β-lapachone on colorectal lung metastasis. This compound may be useful for developing therapeutic agents to treat metastatic cancer.

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