Effect of sodium hydroxybutyrate on the regional circulation and nervous regulation of vascular tone

1975 ◽  
Vol 80 (2) ◽  
pp. 937-940
Author(s):  
�. A. Bendikov ◽  
T. S. Gan'shina
Keyword(s):  
Vascular Tone ◽  
Sodium Hydroxybutyrate ◽  
Nervous Regulation ◽  
Regional Circulation ◽  
Regulation Of Vascular Tone

Neural regulation of vascular tone and cold induced vasoconstriction in human finger skin

1990 ◽  
Vol 30 (2) ◽  
pp. 169-173 ◽  
Author(s):  
Lars Erik Lindblad ◽  
Lena Ekenvall ◽  
Christer Klingstedt
Keyword(s):  
Vascular Tone ◽  
Neural Regulation ◽  
Human Finger ◽  
Finger Skin ◽  
Regulation Of Vascular Tone

Endothelial regulation of vascular tone

1993 ◽  
Vol 17 (6) ◽  
pp. 1143-1144
Author(s):  
John P. Cooke
Keyword(s):  
Vascular Tone ◽  
Regulation Of Vascular Tone

The role of corticosteroids in the regulation of vascular tone

1999 ◽  
Vol 41 (1) ◽  
pp. 55-64 ◽  
Author(s):  
M Ullian
Keyword(s):  
Vascular Tone ◽  
Regulation Of Vascular Tone

Cardiovascular and renal control in NOS-deficient mouse models

2003 ◽  
Vol 284 (3) ◽  
pp. R628-R638 ◽  
Author(s):  
Pablo A. Ortiz ◽  
Jeffrey L. Garvin
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Cardiac Function ◽  
Knockout Mice ◽  
Vascular Tone ◽  
Single Gene ◽  
No Production ◽  
Compensatory Mechanisms ◽  
Nos Isoforms ◽  
Regulation Of Vascular Tone

Nitric oxide (NO) plays an essential role in the maintenance of cardiovascular and renal homeostasis. Endogenous NO is produced by three different NO synthase (NOS) isoforms: endothelial NOS (eNOS), inducible NOS (iNOS), and neuronal NOS (nNOS). To investigate which NOS is responsible for NO production in different tissues, NOS knockout (−/−) mice have been generated for the three isoforms. This review focuses on the regulation of cardiovascular and renal function in relation to blood pressure homeostasis in the different NOS−/− mice. Although regulation of vascular tone and cardiac function in eNOS−/− has been extensively studied, far less is known about renal function in these mice. eNOS−/− mice are hypertensive, but the mechanism responsible for their high blood pressure is still not clear. Less is known about cardiovascular and renal control in nNOS−/− mice, probably because their blood pressure is normal. Recent data suggest that nNOS plays important roles in cardiac function, renal homeostasis, and regulation of vascular tone under certain conditions, but these are only now beginning to be studied. Inasmuch as iNOS is absent from the cardiovascular system under physiological conditions, it may become important to blood pressure regulation only during pathological conditions related to inflammatory processes. However, iNOS is constitutively expressed in the kidney, where its function is largely unknown. Overall, the study of NOS knockout mice has been very useful and produced many answers, but it has also raised new questions. The appearance of compensatory mechanisms suggests the importance of the different isoforms to specific processes, but it also complicates interpretation of the data. In addition, deletion of a single gene may have physiologically significant effects in addition to those being studied. Thus the presence or absence of a specific phenotype may not reflect the most important physiological function of the absent gene.

scholarly journals Endothelial Transporter Spinster 2 (SPNS2) and Apolipoprotein M (ApoM) Regulation of Vascular Tone and Hypertension via Sphingosine‐1‐phosphate (S1P)

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Ilaria Del Gaudio ◽  
Luisa Rubinelli ◽  
Linda Sasset ◽  
Christian Wadsack ◽  
Timothy Hla ◽  
...  
Keyword(s):  
Vascular Tone ◽  
Apolipoprotein M ◽  
Sphingosine 1 Phosphate ◽  
Regulation Of Vascular Tone

scholarly journals Aging and muscle fiber type alter K+ channel contributions to the myogenic response in skeletal muscle arterioles

2009 ◽  
Vol 107 (2) ◽  
pp. 389-398 ◽  
Author(s):  
Lori S. Kang ◽  
SeJeong Kim ◽  
James M. Dominguez ◽  
Amy L. Sindler ◽  
Gregory M. Dick ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Negative Feedback ◽  
Vascular Tone ◽  
Fiber Type ◽  
Myogenic Tone ◽  
Myogenic Response ◽  
Fiber Types ◽  
Age Related ◽  
Myogenic Regulation ◽  
Regulation Of Vascular Tone

Aging diminishes myogenic tone in arterioles from skeletal muscle. Recent evidence indicates that both large-conductance Ca2+-activated (BKCa) and voltage-dependent (KV) K+ channels mediate negative feedback control of the myogenic response. Thus we tested the hypothesis that aging increases the contributions of KV and BKCa channels to myogenic regulation of vascular tone. Because myogenic responsiveness differs between oxidative and glycolytic muscles, we predicted that KV and BKCa channel contributions to myogenic responsiveness vary with fiber type. Myogenic responses of first-order arterioles from the gastrocnemius and soleus muscles of 4- and 24-mo-old Fischer 344 rats were evaluated in the presence and absence of 4-aminopyridine (5 mM) or iberiotoxin (30 nM), inhibitors of KV and BKCa, respectively. 4-Aminopyridine enhanced myogenic tone with aging and normalized age-related differences in both muscle types. By contrast, iberiotoxin eliminated age-related differences in soleus arterioles and had no effect in gastrocnemius vessels. KV1.5 is an integral component of KV channels in vascular smooth muscle; therefore, we determined the relative protein expression of KV1.5, as well as BKCa, in soleus and gastrocnemius arterioles. Immunoblot analysis revealed no differences in KV1.5 protein with aging or between variant fiber types, whereas BKCa protein levels declined with age in arterioles from both muscle groups. Collectively, these results suggest that the contribution of BKCa to myogenic regulation of vascular tone changes with age in soleus muscle arterioles, whereas increased KV channel expression and negative feedback regulation of myogenic tone increases with advancing age in arterioles from both oxidative and glycolytic muscles.

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