Effects of branched-chain amino acids on plasma amino acids in amyotrophic lateral sclerosis

Amino Acids ◽  
1996 ◽  
Vol 11 (1) ◽  
pp. 37-42 ◽  
Author(s):  
O. Gredal ◽  
S. E. M�ller
Keyword(s):  
Amino Acids ◽  
Amyotrophic Lateral Sclerosis ◽  
Branched Chain Amino Acids ◽  
Plasma Amino Acids ◽  
Branched Chain ◽  
Lateral Sclerosis

Complex behavioral and synaptic effects of dietary branched chain amino acids in a mouse model of amyotrophic lateral sclerosis

2011 ◽  
Vol 55 (4) ◽  
pp. 541-552 ◽  
Author(s):  
Aldina Venerosi ◽  
Alberto Martire ◽  
Angela Rungi ◽  
Massimo Pieri ◽  
Antonella Ferrante ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amyotrophic Lateral Sclerosis ◽  
Mouse Model ◽  
Branched Chain Amino Acids ◽  
Branched Chain ◽  
Synaptic Effects ◽  
Lateral Sclerosis

scholarly journals Prediagnostic plasma branched chain amino acids and the risk of amyotrophic lateral sclerosis

Neurology ◽  
2018 ◽  
pp. 10.1212/WNL.0000000000006669
Author(s):  
Kjetil Bjornevik ◽  
Éilis J. O'Reilly ◽  
James D. Berry ◽  
Clary B. Clish ◽  
Sarah Jeanfavre ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amyotrophic Lateral Sclerosis ◽  
Branched Chain Amino Acids ◽  
Branched Chain ◽  
Lateral Sclerosis

Branched Chain Amino Acids in Experimental Models of Amyotrophic Lateral Sclerosis

2015 ◽  
pp. 229-241
Author(s):  
Alessia De Felice ◽  
Annamaria Confaloni ◽  
Alessio Crestini ◽  
Roberta De Simone ◽  
Fiorella Malchiodi-Albedi ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amyotrophic Lateral Sclerosis ◽  
Branched Chain Amino Acids ◽  
Experimental Models ◽  
Branched Chain ◽  
Lateral Sclerosis

Production and utilization of amino acids by ovine placenta in vivo

1998 ◽  
Vol 274 (1) ◽  
pp. E13-E22 ◽  
Author(s):  
Misoo Chung ◽  
Cecilia Teng ◽  
Michelle Timmerman ◽  
Giacomo Meschia ◽  
Frederick C. Battaglia
Keyword(s):  
Amino Acids ◽  
Branched Chain Amino Acids ◽  
Plasma Amino Acids ◽  
Physiological Conditions ◽  
Ovine Placenta ◽  
Branched Chain ◽  
Glutamine Production

Uterine and umbilical uptakes of plasma amino acids were measured simultaneously in eighteen singleton pregnant ewes at 130 ± 1 days gestation for the purpose of establishing which amino acids are produced or used by the uteroplacenta under normal physiological conditions and at what rates. The branched-chain amino acids (BCAA) had uterine uptakes significantly greater than umbilical uptakes. Net uteroplacental BCAA utilization was 8.0 ± 2.5 μmol ⋅ kg fetus−1 ⋅ min−1( P < 0.005) and represented 42% of the total BCAA utilization by fetus plus uteroplacenta. There was placental uptake of fetal glutamate (4.2 ± 0.3 μmol ⋅ kg fetus−1 ⋅ min−1, P < 0.001) and no uterine uptake of maternal glutamate. Umbilical uptake of glutamine was ∼61% greater than uterine uptake, thus demonstrating net uteroplacental glutamine production of 2.2 ± 0.9 μmol ⋅ kg fetus−1 ⋅ min−1( P < 0.021). In conjunction with other evidence, these data indicate rapid placental metabolism of glutamate, which is in part supplied by the fetus and in part produced locally via BCAA transamination. Most of the glutamate is oxidized, and some is used to synthesize glutamine, which is delivered to the fetus. There was net uteroplacental utilization of maternal serine and umbilical uptake of glycine produced by the placenta. Maternal serine utilization and glycine umbilical uptake were virtually equal (3.14 ± 0.50 vs. 3.10 ± 0.46 μmol ⋅ kg fetus−1 ⋅ min−1). This evidence supports the conclusion that the ovine placenta converts large quantities of maternal serine into fetal glycine.

Plasma amino acids concentration in amyotrophic lateral sclerosis patients

Amino Acids ◽  
2003 ◽  
Vol 25 (1) ◽  
pp. 69-73 ◽  
Author(s):  
J. Ilżecka ◽  
Z. Stelmasiak ◽  
J. Solski ◽  
S. Wawrzycki ◽  
M. Szpetnar
Keyword(s):  
Amino Acids ◽  
Amyotrophic Lateral Sclerosis ◽  
Plasma Amino Acids ◽  
Lateral Sclerosis
Sign in / Sign up

Export Citation Format

Share Document