Altered oxidative stress profile in the cortex of mice fed an enriched branched-chain amino acids diet: Possible link with amyotrophic lateral sclerosis?

2011 ◽  
Vol 89 (8) ◽  
pp. 1276-1283 ◽  
Author(s):  
P. Piscopo ◽  
A. Crestini ◽  
A. Adduci ◽  
A. Ferrante ◽  
M. Massari ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Amino Acids ◽  
Amyotrophic Lateral Sclerosis ◽  
Branched Chain Amino Acids ◽  
Stress Profile ◽  
Branched Chain ◽  
Lateral Sclerosis

Complex behavioral and synaptic effects of dietary branched chain amino acids in a mouse model of amyotrophic lateral sclerosis

2011 ◽  
Vol 55 (4) ◽  
pp. 541-552 ◽  
Author(s):  
Aldina Venerosi ◽  
Alberto Martire ◽  
Angela Rungi ◽  
Massimo Pieri ◽  
Antonella Ferrante ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amyotrophic Lateral Sclerosis ◽  
Mouse Model ◽  
Branched Chain Amino Acids ◽  
Branched Chain ◽  
Synaptic Effects ◽  
Lateral Sclerosis

scholarly journals Prediagnostic plasma branched chain amino acids and the risk of amyotrophic lateral sclerosis

Neurology ◽  
2018 ◽  
pp. 10.1212/WNL.0000000000006669
Author(s):  
Kjetil Bjornevik ◽  
Éilis J. O'Reilly ◽  
James D. Berry ◽  
Clary B. Clish ◽  
Sarah Jeanfavre ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amyotrophic Lateral Sclerosis ◽  
Branched Chain Amino Acids ◽  
Branched Chain ◽  
Lateral Sclerosis

Branched Chain Amino Acids in Experimental Models of Amyotrophic Lateral Sclerosis

2015 ◽  
pp. 229-241
Author(s):  
Alessia De Felice ◽  
Annamaria Confaloni ◽  
Alessio Crestini ◽  
Roberta De Simone ◽  
Fiorella Malchiodi-Albedi ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amyotrophic Lateral Sclerosis ◽  
Branched Chain Amino Acids ◽  
Experimental Models ◽  
Branched Chain ◽  
Lateral Sclerosis

scholarly journals Branched‐chain amino acids reduce hepatic iron accumulation and oxidative stress in hepatitis C virus polyprotein‐expressing mice

2014 ◽  
Vol 35 (4) ◽  
pp. 1303-1314 ◽  
Author(s):  
Masaaki Korenaga ◽  
Sohji Nishina ◽  
Keiko Korenaga ◽  
Yasuyuki Tomiyama ◽  
Naoko Yoshioka ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Amino Acids ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Branched Chain Amino Acids ◽  
Iron Accumulation ◽  
Hepatic Iron ◽  
Branched Chain ◽  
Virus Polyprotein ◽  
And Oxidative Stress

Branched chain amino Acids as in vitro and in vivo Anti-Oxidation Compounds

2021 ◽  
pp. 3899-3904
Author(s):  
Moath Alqaraleh ◽  
Violet Kasabri ◽  
Ibrahim Al-Majali ◽  
Nihad Al-Othman ◽  
Nihad Al-Othman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Amino Acids ◽  
Branched Chain Amino Acids ◽  
Raw 264.7 ◽  
Raw 264.7 Cell ◽  
Branched Chain ◽  
Raw 264.7 Cell Line

Background and aims: Branched chain amino acids (BCAAs) can be tightly connected to metabolism syndrome (MetS) which can be counted as a metabolic indicator in the case of insulin resistance (IR). The aim of this study was to assess the potential role of these acids under oxidative stress. Material and Methods: the in vitro antioxidant activity of BCAAs was assessed using free radical 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) scavenging assays. For further check, a qRT-PCR technique was madefor detection the extent of alterations in gene expression of antioxidative enzymes (catalase and glutathione peroxidase (Gpx)) in lipopolysaccharides (LPS(-induced macrophages RAW 264.7 cell line. Additionally, BCAAs antioxidant activity was evaluated based on plasma H2O2 levels and xanthine oxidase (XO) activity in prooxidative LPS-treated mice. Results: Different concentrations of BCAAs affected on DPPH radical scavenging activity but to lesser extent than the ascorbic acid. Besides, BCAAs obviously upregulated the gene expression levels of catalases and Gpx in LPS-modulated macrophage RAW 264.7 cell line. In vivo BCAAs significantly minimized the level of plasma H2O2 as well as the activity of XO activity under oxidative stress. Conclusion: our current findings suggest that BCAAs supplementation may potentially serve as a therapeutic target for treatment of oxidative stress occurs with atherosclerosis, IR-diabetes, MetS and tumorigenesis.

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