Renal proximal tubular epithelium from patients with nephropathic cystinosis: Immortalized cell lines asin vitro model systems

1996 ◽  
Vol 10 (3) ◽  
pp. 394-394
Author(s):  
Lorraine C. Racusen ◽  
Patricia D. Wilson ◽  
Patricia A. Hartz ◽  
Barbara A. Fivush ◽  
Christopher R. Burrow ◽  
...  
Keyword(s):  
Cell Lines ◽  
Model Systems ◽  
Nephropathic Cystinosis ◽  
Tubular Epithelium ◽  
Immortalized Cell Lines ◽  
Proximal Tubular ◽  
Vitro Model ◽  
Renal Proximal Tubular ◽  
Immortalized Cell ◽  
Proximal Tubular Epithelium

scholarly journals Renal proximal tubular epithelium from patients with nephropathic cystinosis: Immortalized cell lines as in vitro model systems

1995 ◽  
Vol 48 (2) ◽  
pp. 536-543 ◽  
Author(s):  
Lorraine C. Racusen ◽  
◽  
Patricia D. Wilson ◽  
Patricia A. Hartz ◽  
Barbara A. Fivush ◽  
...  
Keyword(s):  
In Vitro Model ◽  
Model Systems ◽  
Nephropathic Cystinosis ◽  
Tubular Epithelium ◽  
Proximal Tubular ◽  
Vitro Model ◽  
Renal Proximal Tubular ◽  
Immortalized Cell ◽  
Proximal Tubular Epithelium

scholarly journals Molecular Mechanisms of Receptor-Mediated Endocytosis in the Renal Proximal Tubular Epithelium

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Akihiko Saito ◽  
Hiroyoshi Sato ◽  
Noriaki Iino ◽  
Tetsuro Takeda
Keyword(s):  
Molecular Mechanisms ◽  
Adaptor Proteins ◽  
Risk Marker ◽  
Tubular Epithelium ◽  
Coated Pits ◽  
Receptor Mediated Endocytosis ◽  
Other Substances ◽  
Proximal Tubular ◽  
Renal Proximal Tubular ◽  
Proximal Tubular Epithelium

Receptor-mediated endocytosis is a pivotal function of renal proximal tubule epithelial cells (PTECs) to reabsorb and metabolize substantial amounts of proteins and other substances in glomerular filtrates. The function accounts for the conservation of nutrients, including carrier-bound vitamins and trace elements, filtered by glomeruli. Impairment of the process results in a loss of such substances and development of proteinuria, an important clinical sign of kidney disease and a risk marker for cardiovascular disease. Megalin is a multiligand endocytic receptor expressed at clathrin-coated pits of PTEC, playing a central role in the process. Megalin cooperates with various membrane molecules and interacts with many intracellular adaptor proteins for endocytic trafficking. Megalin is also involved in signaling pathways in the cells. Megalin-mediated endocytic overload leads to damage of PTEC. Further studies are needed to elucidate the mechanism of megalin-mediated endocytosis and develop strategies for preventing the damage of PTEC.

Ioxaglate-Induced Light and Electron Microscopic Alterations in the Renal Proximal Tubular Epithelium of Rats

1991 ◽  
Vol 26 (1) ◽  
pp. 35-39 ◽  
Author(s):  
ROGER BATTENFELD ◽  
ABD EL RAHMAN KHATER ◽  
WOLFGANG DROMMER ◽  
PETER GUENZEL ◽  
FRANZ-JOSEF KAUP
Keyword(s):  
Tubular Epithelium ◽  
Electron Microscopic ◽  
Proximal Tubular ◽  
Renal Proximal Tubular ◽  
Proximal Tubular Epithelium

Characterization of Cytoplasmic Lysozyme Immunoreactivity as a Histiocytic Marker in Normal Canine Tissues

1986 ◽  
Vol 23 (6) ◽  
pp. 763-769 ◽  
Author(s):  
P. F. Moore
Keyword(s):  
Langerhans Cells ◽  
Lymphoid Tissues ◽  
Nonspecific Esterase ◽  
Tubular Epithelium ◽  
Follicular Dendritic Cells ◽  
Proximal Tubular ◽  
Renal Proximal Tubular ◽  
Antigen Presenting ◽  
Proximal Tubular Epithelium

The immunoreactive lysozyme distribution in normal canine tissues was determined to assess the value of lysozyme as a marker of histiocytic differentiation. Lysozyme was largely confined to monocytes, neutrophils, macrophages, serous cells in mucosal associated exocrine glands, and renal proximal tubular epithelium. Macrophages in the majority of tissues stained intensely for lysozyme, although in lymphoid tissues not all acid phosphatase and nonspecific esterase positive cells contained lysozyme. In particular, dendritic antigen presenting cells, including Langerhans cells, follicular dendritic cells, and interdigitating reticulum cells, lacked immunoreactive lysozyme; hence lysozyme appeared to represent a discriminatory marker with respect to these cells. Also, a small proportion of non-dendritic macrophages appeared to lack lysozyme. It was concluded that the demonstration of immunoreactive lysozyme was a useful adjunct to conventional morphological techniques for the identification of tissue macrophages provided that due caution was exercised in the interpretation of the results of lysozyme staining.

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