In vivo acylation of proteolipid protein and DM-20 in myelin and myelin subfractions of developing rat brain: Immunoblot identification of acylated PLP and DM-20

1983 ◽  
Vol 8 (5) ◽  
pp. 649-659 ◽  
Author(s):  
Margaret M. Garwood ◽  
William R. Gilbert ◽  
Harish C. Agrawal
Keyword(s):  
Rat Brain ◽  
Proteolipid Protein ◽  
Myelin Subfractions ◽  
Developing Rat

THE FORMATION OF PHOSPHOLIPIDS FROM14C?LABELLED PRECURSORS IN DEVELOPING RAT BRAIN IN VIVO

1963 ◽  
Vol 10 (7) ◽  
pp. 495-502 ◽  
Author(s):  
E. T. Pritchard
Keyword(s):  
Rat Brain ◽  
Developing Rat

Regulation of in vivo glutamine synthetase activity by glucocorticoids in the developing rat brain

1983 ◽  
Vol 10 (1) ◽  
pp. 83-91 ◽  
Author(s):  
A.J. Patel ◽  
A. Hunt ◽  
C.S.M. Tahourdin
Keyword(s):  
Glutamine Synthetase ◽  
Rat Brain ◽  
Synthetase Activity ◽  
Glutamine Synthetase Activity ◽  
Developing Rat

scholarly journals Turnover of myelin and other structural proteins in the developing rat brain

1974 ◽  
Vol 142 (3) ◽  
pp. 499-507 ◽  
Author(s):  
M. I. Sabri ◽  
A. H. Bone ◽  
A. N. Davison
Keyword(s):  
Rat Brain ◽  
Slow Component ◽  
Proteolipid Protein ◽  
Myelin Proteins ◽  
Turnover Rates ◽  
Basic Proteins ◽  
Glucose Injection ◽  
Total Brain ◽  
The Difference ◽  
Developing Rat

1. Protein metabolism of myelin and other subcellular components from developing rat brain was studied for periods from 5h to 210 days after intraperitoneal injection of [3H]lysine and [14C]glucose. 2. Half-lives for total brain proteins (t0.5) were 27 days after [3H]lysine and 4 days after [14C]glucose injection. 3. Factors accounting for the difference in the turnover rates obtained with different precursors, and the problem of reutilization of the label were investigated. 4. The catabolism of purified myelin proteins was studied and the half-lives of individual myelin proteins were calculated. 5. Myelin basic proteins turned over at two different rates. Half-life of the fast component of myelin basic proteins was 19–22 days and the slow component exhibited a high degree of metabolic stability. 6. Proteolipid protein underwent slow turnover. High-molecular-weight Wolfgram (1966) proteins underwent (relatively) fast metabolism (t0.5 of 17–22 days).

scholarly journals Differentiation and Death of Premyelinating Oligodendrocytes in Developing Rodent Brain

1997 ◽  
Vol 137 (2) ◽  
pp. 459-468 ◽  
Author(s):  
Bruce D. Trapp ◽  
Akiko Nishiyama ◽  
David Cheng ◽  
Wendy Macklin
Keyword(s):  
Cerebral Cortex ◽  
Corpus Callosum ◽  
Rat Brain ◽  
Protein Gene ◽  
Proteolipid Protein ◽  
Gene Products ◽  
Rodent Brain ◽  
Developing Rat

Previous studies have indicated that newly formed oligodendrocytes are dynamic cells whose production, survival, and differentiation depend upon axonal influences. This study has characterized the appearance and fate of newly formed oligodendrocytes in developing rat brain. Oligodendrocytes appear in predictable locations and radially extend DM-20–positive processes that cover 80-μm domains in the cortex and 40-μm domains in the corpus callosum. These premyelinating oligodendrocytes have one of two fates: they myelinate axons or degenerate. Between 7 and 21 d after birth, ∼20% of premyelinating oligodendrocytes identified in the cerebral cortex were degenerating. Oligodendrocytes that ensheathed axons expressed and selectively targeted proteolipid protein to compact myelin and did not degenerate. These observations support the hypothesis that axonal influences affect oligodendrocyte survival, differentiation, and expression of proteolipid protein gene products.

scholarly journals Fas/CD95/APO-1 Can Function as a Death Receptor for Neuronal Cells in Vitro and in Vivo and is Upregulated Following Cerebral Hypoxic-Ischemic Injury to the Developing Rat Brain

2006 ◽  
Vol 10 (1) ◽  
pp. 17-29 ◽  
Author(s):  
Ursula Felderhoff-Mueser ◽  
Deanna L. Taylor ◽  
Kirsty Greenwood ◽  
Mary Kozma ◽  
Dietger Stibenz ◽  
...  
Keyword(s):  
Rat Brain ◽  
Neuronal Cells ◽  
Death Receptor ◽  
Ischemic Injury ◽  
Developing Rat ◽  
Hypoxic Ischemic Injury

scholarly journals Effect of hyperphenylalaninaemia on lipid synthesis from ketone bodies by rat brain

1976 ◽  
Vol 154 (2) ◽  
pp. 319-325 ◽  
Author(s):  
M S. Patel ◽  
O E. Owen
Keyword(s):  
Rat Brain ◽  
Ketone Bodies ◽  
Brain Slices ◽  
Lipid Synthesis ◽  
Coa Transferase ◽  
Old Rats ◽  
And Function ◽  
Developing Rat

The effect of hyperphenylalaninaemia on the metabolism of ketone bodies in vivo and in vitro by developing rat brain was investigated. The incorporation in vivo of [14C]acetoacetate into cerebral lipids was decreased by both chronic (for 3 days) and acute (for 6h) hyperphenylalaninaemia induced by injecting phenylalanine into 1-week-old rats. In studies in vitro it was observed that the incorporation of the radioactivity from [14C]acetoacetate and 3-hydroxy[14C]butyrate into cerebral lipids was inhibited by phenyl-pyruvate, but not by phenylalanine. Phenylpyruvate also inhibited the incorporation of 3H from 3H2O into lipids by brain slices metabolizing either 3-hydroxybutyrate or acetoacetate in the presence of glucose. These findings suggest that the decrease in the incorporation in vivo of [14C]acetoacetate into cerebral lipids in hyperphenylalaninaemic rats is most likely caused by phenylpyruvate and not by phenylalanine. Phenylpyruvate as well as phenylalanine had no inhibitory effects on ketone-body-catabolizing enzymes, namely 3-hydroxybutyrate dehydrogenase, 3-oxo acid CoA-transferase and acetoacetyl-CoA thiolase, in rat brain. Phenylpyruvate but not phenylalanine inhibited the activity of the 2-oxoglutarate dehydrogenase complex from rat and human brain. These findings suggest that the metabolism of ketone bodies is impaired in brains of untreated phenylketonuric patients, and in turn may contribute to the diminution of mental development and function associated with phenylketonuria.

scholarly journals The CRF1 receptor mediates the excitatory actions of corticotropin releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonist

1997 ◽  
Vol 770 (1-2) ◽  
pp. 89-95 ◽  
Author(s):  
Tallie Z Baram ◽  
Derek T Chalmers ◽  
Chen Chen ◽  
Yani Koutsoukos ◽  
Errol B De Souza
Keyword(s):  
Receptor Antagonist ◽  
Rat Brain ◽  
Corticotropin Releasing Factor ◽  
Crf1 Receptor ◽  
Developing Rat

scholarly journals In Vivo 1H Nuclear Magnetic Resonance Spectroscopy (MRS) with a 9.4T Magnet for Evaluation of Hippocampal Metabolism in the Developing Rat Brain

1999 ◽  
Vol 45 (4, Part 2 of 2) ◽  
pp. 346A-346A
Author(s):  
Raghavendra Rao ◽  
Marissa De Ungria ◽  
Ivan Tkac ◽  
Josef Pfeuffer ◽  
Rolf Gruetter ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Rat Brain ◽  
Nuclear Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
1H Nuclear Magnetic Resonance ◽  
Developing Rat ◽  
Nuclear Magnetic

scholarly journals In vivo acylation of rat brain myelin proteolipid protein.

1982 ◽  
Vol 257 (8) ◽  
pp. 4588-4592 ◽  
Author(s):  
H C Agrawal ◽  
C L Randle ◽  
D Agrawal
Keyword(s):  
Rat Brain ◽  
Proteolipid Protein ◽  
Myelin Proteolipid Protein ◽  
Myelin Proteolipid

In vivo ethanol decreases phosphorylated MAPK and p70S6 kinase in the developing rat brain

Neuroreport ◽  
2003 ◽  
Vol 14 (10) ◽  
pp. 1395-1399 ◽  
Author(s):  
Ryozo Tsuji ◽  
Marina Guizzetti ◽  
Lucio G. Costa
Keyword(s):  
Rat Brain ◽  
P70s6 Kinase ◽  
Developing Rat
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