Hepatic clearance of unconjugated bilirubin in cholestatic liver diseases

1974 ◽  
Vol 19 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Joseph R. Bloomer ◽  
Paul D. Berk ◽  
Robert B. Howe
Keyword(s):  
Liver Diseases ◽  
Hepatic Clearance ◽  
Unconjugated Bilirubin

Studies on the Kinetics of Unconjugated [14C]Bilirubin Metabolism in Normal Subjects and Patients with Compensated Cirrhosis

1977 ◽  
Vol 52 (6) ◽  
pp. 555-570
Author(s):  
D. Owens ◽  
E. A. Jones ◽  
E. R. Carson
Keyword(s):  
Cell Function ◽  
Hepatic Clearance ◽  
Normal Subjects ◽  
Volume Of Distribution ◽  
Unconjugated Bilirubin ◽  
Group Of Seven ◽  
Compensated Cirrhosis ◽  
Bilirubin Metabolism ◽  
The Mean ◽  
Kinetics Of

1. The kinetics of unconjugated [14C]-bilirubin metabolism have been investigated and analysed in terms of a three-pool model in a group of seven normal subjects and in a group of eight cirrhotic patients who had appreciable impairment of liver cell function. 2. In the patients with cirrhosis, the plasma unconjugated bilirubin was either normal or only slightly increased but the metabolism of unconjugated bilirubin was deranged. 3. The mean volume of distribution, the mean 4 h retention, and the mean mass of the rapidly mixing pool were all significantly greater than in the normal subjects. In contrast, mean fractional clearance rate and mean estimated erythrocyte life-span were significantly less than in the normal subjects. 4. The mean fractional transfer rates and fluxes from pool 1 (rapidly mixing pool—‘plasma’) to pool 3 (‘extravascular’) and vice versa were significantly greater than the corresponding values in the normal subjects. 5. The results indicate that, in patients with compensated cirrhosis, the efficiency of the liver in extracting unconjugated bilirubin from plasma against a concentration gradient is impaired, even though the liver's capacity to conjugate bilirubin may be normal. As a consequence of the increased volume of distribution, the absolute hepatic clearance of unconjugated bilirubin is relatively well maintained.

The miR-21 potential of serving as a biomarker for liver diseases in clinical practice

2020 ◽  
Vol 48 (5) ◽  
pp. 2295-2305
Author(s):  
Jiawei Zhang ◽  
Dandan Li ◽  
Rui Zhang ◽  
Peng Gao ◽  
Rongxue Peng ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Liver Diseases ◽  
Hepatic Disease ◽  
Noninvasive Detection ◽  
Diagnosis And Prognosis ◽  
Expected Performance ◽  
Potential Biomarker ◽  
Disease Condition ◽  
Complex Regulatory Network

The role of miR-21 in the pathogenesis of various liver diseases, together with the possibility of detecting microRNA in the circulation, makes miR-21 a potential biomarker for noninvasive detection. In this review, we summarize the potential utility of extracellular miR-21 in the clinical management of hepatic disease patients and compared it with the current clinical practice. MiR-21 shows screening and prognostic value for liver cancer. In liver cirrhosis, miR-21 may serve as a biomarker for the differentiating diagnosis and prognosis. MiR-21 is also a potential biomarker for the severity of hepatitis. We elucidate the disease condition under which miR-21 testing can reach the expected performance. Though miR-21 is a key regulator of liver diseases, microRNAs coordinate with each other in the complex regulatory network. As a result, the performance of miR-21 is better when combined with other microRNAs or classical biomarkers under certain clinical circumstances.

Helicobacter infection in patients with HCV-chronic liver diseases

2001 ◽  
Vol 120 (5) ◽  
pp. A725-A725
Author(s):  
M DORE ◽  
G REALDI ◽  
D MURA ◽  
D GRAHAM ◽  
A SEPULVEDA
Keyword(s):  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Diseases

A Comparative Study of the Colloidal Red Test in Liver Diseases with Special Reference to the Zinc Turbidity, Thymol Turbidity and Bromsulphalein Tests

1949 ◽  
Vol 12 (6) ◽  
pp. 934-948 ◽  
Author(s):  
Henry A. Strade ◽  
Louis B. Dotti ◽  
Stephanie J. Ilka
Keyword(s):  
Comparative Study ◽  
Special Reference ◽  
Liver Diseases ◽  
Thymol Turbidity

American Association For the Study of Liver Diseases

1964 ◽  
Vol 46 (3) ◽  
pp. 299-316
Keyword(s):  
Liver Diseases ◽  
American Association

American Association for the Study of Liver Diseases

1962 ◽  
Vol 42 (4) ◽  
pp. 465-480 ◽  
Keyword(s):  
Liver Diseases ◽  
American Association

Minilaparoscopy as a new technique for the diagnosis and staging of liver diseases

2001 ◽  
Vol 34 (0) ◽  
pp. 228
Author(s):  
J Gschossmann
Keyword(s):  
Liver Diseases ◽  
New Technique ◽  
A New Technique

Gastric Bypass Surgery Improves Liver Diseases

2005 ◽  
Vol 35 (24) ◽  
pp. 53
Author(s):  
MICHELE G. SULLIVAN
Keyword(s):  
Gastric Bypass ◽  
Liver Diseases ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery
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