The mechanism of inhibition of ureogenesis by acidosis

1984 ◽  
Vol 4 (10) ◽  
pp. 819-825 ◽  
Author(s):  
J. P. Monson ◽  
R. M. Henderson ◽  
J. A. Smith ◽  
R. A. Iles ◽  
M. Faus-Dader ◽  
...  
Keyword(s):  
Ammonium Chloride ◽  
Rat Liver ◽  
Rat Hepatocytes ◽  
Ph Sensitive ◽  
Perfused Rat Liver ◽  
Carbamoyl Phosphate ◽  
Isolated Rat Hepatocytes ◽  
Mechanism Of Inhibition ◽  
Cytosol Ph ◽  
Isolated Rat

In perfused rat liver a decrease of cytosol pH, determined with pH-sensitive microelectrodes7 from 7.2 to 6.85 is associated with a 50% fall in ureogenesis from ammonium chloride. In isolated rat hepatocytes the fall in ureogenesis due to acidosis is associated with decrease in the mitochondrial and cytosolic concentration of citrulline. Limitation of carbamoyl phosphate synthesis and thus citrulline supply could be responsible for the inhibition of ureogenesis observed.

Biosynthesis of Guanidine in Isolated Rat Hepatocytes, Perfused Rat Liver and Intact Animals

Nephron ◽  
1994 ◽  
Vol 67 (3) ◽  
pp. 334-339 ◽  
Author(s):  
Katsumi Takemura ◽  
Sohji Nagase ◽  
Kazumasa Aoyagi ◽  
Michihiro Gotoh ◽  
Akio Koyama ◽  
...  
Keyword(s):  
Rat Liver ◽  
Rat Hepatocytes ◽  
Perfused Rat Liver ◽  
Isolated Rat Hepatocytes ◽  
Isolated Rat

Hepatotoxic effect of (+)usnic acid from Usnea siamensis Wainio in rats, isolated rat hepatocytes and isolated rat liver mitochondria

2004 ◽  
Vol 90 (2-3) ◽  
pp. 381-387 ◽  
Author(s):  
Pornpen Pramyothin ◽  
Withaya Janthasoot ◽  
Nushjira Pongnimitprasert ◽  
Siriwan Phrukudom ◽  
Nijsiri Ruangrungsi
Keyword(s):  
Rat Liver ◽  
Usnic Acid ◽  
Rat Hepatocytes ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Isolated Rat Hepatocytes ◽  
Isolated Rat Liver ◽  
Hepatotoxic Effect ◽  
Isolated Rat

Separation of the Intracellular Secretory Compartment of Rat Liver and Isolated Rat Hepatocytes in a Single Step Using Self-Generating Gradients of Iodixanol

1999 ◽  
Vol 276 (1) ◽  
pp. 88-96 ◽  
Author(s):  
Dietmar Plonne ◽  
Ian Cartwright ◽  
Werner Linß ◽  
Rolf Dargel ◽  
John M. Graham ◽  
...  
Keyword(s):  
Rat Liver ◽  
Rat Hepatocytes ◽  
Single Step ◽  
Isolated Rat Hepatocytes ◽  
Isolated Rat

scholarly journals Inhibition of phosphatidylcholine synthesis by vasopressin and angiotensin in rat hepatocytes

1982 ◽  
Vol 208 (2) ◽  
pp. 453-457 ◽  
Author(s):  
S Alemany ◽  
I Varela ◽  
J M Mato
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
Rat Hepatocytes ◽  
Rat Liver Microsomes ◽  
Isolated Rat Hepatocytes ◽  
Fast Transient ◽  
Phosphatidylcholine Synthesis ◽  
Isolated Rat

The addition of 1 microM-vasopressin or -angiotensin to isolated rat hepatocytes induced a fast transient inhibition of the rate of incorporation of [Me-3H]choline into phosphatidylcholine. The cationophore A23187 induced a similar inhibition of phosphatidylcholine synthesis. The addition of micromolar Ca2+ to rat liver microsomes inhibited the activity of CDP-choline: 1,2-diacylglycerol cholinephosphotransferase. This inhibition is due a decrease in the Vmax. of the enzyme without affecting the Km for CDP-choline. It is concluded that Ca2+ regulates phosphatidylcholine synthesis in rat liver.

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