Restricted replication of adenovirus type 2 in mouse balb/3T3 cells

1986 ◽  
Vol 87 (3-4) ◽  
pp. 241-264 ◽  
Author(s):  
G. Silverstein ◽  
W. A. Strohl
Keyword(s):  
Adenovirus Type ◽  
3T3 Cells ◽  
Adenovirus Type 2

scholarly journals Adenovirus type 2 activates cell cycle-dependent genes that are a subset of those activated by serum.

1985 ◽  
Vol 5 (11) ◽  
pp. 2936-2942 ◽  
Author(s):  
H T Liu ◽  
R Baserga ◽  
W E Mercer
Keyword(s):  
Cell Cycle ◽  
Dna Synthesis ◽  
Thymidine Kinase ◽  
Histone H3 ◽  
Adenovirus Type ◽  
3T3 Cells ◽  
Cycle Dependent ◽  
Cellular Dna ◽  
Adenovirus Type 2

We have studied a panel of 10 genes and cDNA sequences that are expressed in a cell cycle-dependent manner in different types of cells from different species and that are inducible by different mitogens. These include five sequences (c-myc, 4F1, 2F1, 2A9, and KC-1) that are preferentially expressed in the early part of the G1 phase, three genes (ornithine decarboxylase, p53, and c-rasHa) preferentially expressed in middle or late G1, and two genes (thymidine kinase and histone H3) preferentially expressed in the S phase of the cell cycle. We have studied the expression of these genes in nonpermissive (tsAF8) and semipermissive (Swiss 3T3) cells infected with adenovirus type 2. Under the conditions of these experiments, adenovirus type 2 infection stimulates cellular DNA synthesis in both tsAF8 and 3T3 cells. However, four of the five early G1 genes (c-myc, 4F1, KC-1, and 2A9) and one of the late G1 genes (c-ras) are not induced by adenovirus infection, although they are strongly induced by serum. The other sequences (2F1, ornithine decarboxylase, p53, thymidine kinase, and histone H3) are activated by both adenovirus and serum. We conclude that the cell cycle-dependent genes activated by adenovirus 2 are a subset of the cell cycle-dependent genes activated by serum. The data suggest that the mechanisms by which serum and adenovirus induce cellular DNA synthesis are not identical.

Adenovirus type 2 activates cell cycle-dependent genes that are a subset of those activated by serum

1985 ◽  
Vol 5 (11) ◽  
pp. 2936-2942
Author(s):  
H T Liu ◽  
R Baserga ◽  
W E Mercer
Keyword(s):  
Cell Cycle ◽  
Dna Synthesis ◽  
Thymidine Kinase ◽  
Histone H3 ◽  
Adenovirus Type ◽  
3T3 Cells ◽  
Cycle Dependent ◽  
Cellular Dna ◽  
Adenovirus Type 2

We have studied a panel of 10 genes and cDNA sequences that are expressed in a cell cycle-dependent manner in different types of cells from different species and that are inducible by different mitogens. These include five sequences (c-myc, 4F1, 2F1, 2A9, and KC-1) that are preferentially expressed in the early part of the G1 phase, three genes (ornithine decarboxylase, p53, and c-rasHa) preferentially expressed in middle or late G1, and two genes (thymidine kinase and histone H3) preferentially expressed in the S phase of the cell cycle. We have studied the expression of these genes in nonpermissive (tsAF8) and semipermissive (Swiss 3T3) cells infected with adenovirus type 2. Under the conditions of these experiments, adenovirus type 2 infection stimulates cellular DNA synthesis in both tsAF8 and 3T3 cells. However, four of the five early G1 genes (c-myc, 4F1, KC-1, and 2A9) and one of the late G1 genes (c-ras) are not induced by adenovirus infection, although they are strongly induced by serum. The other sequences (2F1, ornithine decarboxylase, p53, thymidine kinase, and histone H3) are activated by both adenovirus and serum. We conclude that the cell cycle-dependent genes activated by adenovirus 2 are a subset of the cell cycle-dependent genes activated by serum. The data suggest that the mechanisms by which serum and adenovirus induce cellular DNA synthesis are not identical.

Uncoating of adenovirus type 2.

1979 ◽  
Vol 30 (2) ◽  
pp. 462-471 ◽  
Author(s):  
M A Mirza ◽  
J Weber
Keyword(s):  
Adenovirus Type ◽  
Adenovirus Type 2

Adenovirus type 2 DNA replication. II. Termini of DNA replication.

1975 ◽  
Vol 16 (4) ◽  
pp. 767-774 ◽  
Author(s):  
R Schilling ◽  
B Weingärtner ◽  
E L Winnacker
Keyword(s):  
Dna Replication ◽  
Adenovirus Type ◽  
Adenovirus Type 2

Termination sites for adenovirus type 2 DNA replication.

1975 ◽  
Vol 16 (4) ◽  
pp. 759-766 ◽  
Author(s):  
A Tolun ◽  
U Pettersson
Keyword(s):  
Dna Replication ◽  
Adenovirus Type ◽  
Adenovirus Type 2

Adenovirus type 2 coded single-stranded DNA binding protein: in vivo phosphorylation and modification.

1977 ◽  
Vol 22 (2) ◽  
pp. 402-411 ◽  
Author(s):  
Y H Jeng ◽  
W S Wold ◽  
K Sugawara ◽  
Z Gilead ◽  
M Green
Keyword(s):  
Dna Binding ◽  
Binding Protein ◽  
Adenovirus Type ◽  
Dna Binding Protein ◽  
Single Stranded Dna ◽  
Adenovirus Type 2
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