Unscheduled DNA-synthesis in UV-irradiated spleen lymphocytes of the rat after whole-body X-irradiation

1978 ◽  
Vol 15 (1) ◽  
pp. 77-83 ◽  
Author(s):  
R. Hollatz ◽  
K. Tempel
Keyword(s):  
Dna Synthesis ◽  
Whole Body ◽  
Unscheduled Dna Synthesis ◽  
X Irradiation ◽  
Spleen Lymphocytes

Unprogrammierte DNA-Synthese (DNA-Reparatur) in Milz-und Thymuszellen der Ratte nach Einwirkung von UV-Licht, Röntgenstrahlen oder Methylmethansulfonat in vitro / Unscheduled DNA Synthesis (DNA-Repair) within Splenic and Thymic Cells of the Rat under the Influence of UV-Light, X-Irradiation and/or Methyl-methanesulfonate

1980 ◽  
Vol 35 (1-2) ◽  
pp. 106-111 ◽  
Author(s):  
K. Tempel
Keyword(s):  
Dna Repair ◽  
Dna Synthesis ◽  
Excision Repair ◽  
Uv Light ◽  
Methyl Methanesulfonate ◽  
X Rays ◽  
Unscheduled Dna Synthesis ◽  
Splenic Cells ◽  
X Irradiation

Abstract DNA -Repair, Splenocytes, Thymocytes, Irradiation, Methyl-M ethanesulfonate Unscheduled DNA synthesis (UDS) of splenic and thymic cells of the rat has been stimulated in vitro by UV-light (8-128 J × m-2), X-rays (120-3480 rd), methyl-methanesulfonate (MMS), and/or a combination of UV-light and X -irradiation. The height of U DS-induced stim ulation of incorporation of [3H] thymidine into splenic and thymic cell DNA at saturation doses of UV-light (splenic cells: 8, thymic cells: 96 J × m-2) or X -irradiation (splenic cells: 960, thymic cells:~3480 rd) suggest that the greater sensitivity of T-cells (represented by thymic cells) towards UV-light and the greater sensitivity of B-cells (represented by splenic cells) towards X-rays can be explained - at least partly - in terms of less efficient excision repair systems.

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