Respiration and acid-base balance of blood after diffuse experimental brain injury

1975 ◽  
Vol 32 (1-2) ◽  
pp. 3-12
Author(s):  
S. Valtonen
1972 ◽  
Vol 36 (5) ◽  
pp. 625-633 ◽  
Author(s):  
Markku Kaste ◽  
Henry Troupp

✓ Changes in the blood pressure, cerebral sinus pressure, cerebral venous oxygen tension, acid-base balance, respiratory frequency, and respiratory minute volume were studied in the rabbit after a lethal cold injury to the brain. About half of the animals responded to the injury with a quick rise in cerebral sinus pressure and in its relation to blood pressure (CSP/BP); in the other half, cerebral sinus pressure and the CSP/BP ratio rose more slowly. Changes in the CSP/BP ratio correlated well with criteria for changes in respiratory performance. The changes in cerebral venous oxygen tension were reasonably uniform: a dip during freezing, an overshoot to a mean of 1.6 times the original level (about 30 mm Hg) immediately after injury, a gradual return to the pretraumatic level, and then a drop to lower levels. The brain injury led to a respiratory alkalosis that became more pronounced the longer the animals lived. Considered with CSP/BP ratio, respiratory reaction to the brain injury may provide an early and accurate prognosis. The fact that at the time of death the cerebral perfusion pressure was still within a range believed safe for the brain shows that an actual brain injury, in addition to raised intracranial pressure, is important in such experiments and emphasizes the inappropriateness of comparing levels of intracranial pressure raised by a variety of methods.


2014 ◽  
Vol 84 (3-4) ◽  
pp. 0206-0217 ◽  
Author(s):  
Seyedeh-Elaheh Shariati-Bafghi ◽  
Elaheh Nosrat-Mirshekarlou ◽  
Mohsen Karamati ◽  
Bahram Rashidkhani

Findings of studies on the link between dietary acid-base balance and bone mass are relatively mixed. We examined the association between dietary acid-base balance and bone mineral density (BMD) in a sample of Iranian women, hypothesizing that a higher dietary acidity would be inversely associated with BMD, even when dietary calcium intake is adequate. In this cross-sectional study, lumbar spine and femoral neck BMDs of 151 postmenopausal women aged 50 - 85 years were measured using dual-energy x-ray absorptiometry. Dietary intakes were assessed using a validated food frequency questionnaire. Renal net acid excretion (RNAE), an estimate of acid-base balance, was then calculated indirectly from the diet using the formulae of Remer (based on dietary intakes of protein, phosphorus, potassium, and magnesium; RNAERemer) and Frassetto (based on dietary intakes of protein and potassium; RNAEFrassetto), and was energy adjusted by the residual method. After adjusting for potential confounders, multivariable adjusted means of the lumbar spine BMD of women in the highest tertiles of RNAERemer and RNAEFrassetto were significantly lower than those in the lowest tertiles (for RNAERemer: mean difference -0.084 g/cm2; P=0.007 and for RNAEFrassetto: mean difference - 0.088 g/cm2; P=0.004). Similar results were observed in a subgroup analysis of subjects with dietary calcium intake of >800 mg/day. In conclusion, a higher RNAE (i. e. more dietary acidity), which is associated with greater intake of acid-generating foods and lower intake of alkali-generating foods, may be involved in deteriorating the bone health of postmenopausal Iranian women, even in the context of adequate dietary calcium intake.


2016 ◽  
Vol 24 (3) ◽  
pp. 116-121
Author(s):  
김지용 ◽  
남상욱 ◽  
김영미 ◽  
이윤진 ◽  
이훈상 ◽  
...  

1932 ◽  
Vol 98 (1) ◽  
pp. 253-260 ◽  
Author(s):  
Victor C. Myers ◽  
Edward Muntwyler ◽  
Arthur H. Bill

Author(s):  
Smita Kaushik

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