The effect of minoxidil on blood pressure and plasma renin activity in patients with essential and renal hypertension

1976 ◽  
Vol 54 (15) ◽  
pp. 727-734 ◽  
Author(s):  
C. Werning
Keyword(s):  
Blood Pressure ◽  
Plasma Renin Activity ◽  
Renal Hypertension ◽  
Plasma Renin ◽  
Renin Activity

Effects of Salt and Water Depletion on the Early Phase of Hypertension in Goldblatt two-Kidney Hypertensive Dogs

1981 ◽  
Vol 60 (6) ◽  
pp. 625-631
Author(s):  
M. L. Watson ◽  
J. McCormick ◽  
A. Thom ◽  
P. Whelpdale ◽  
A. Ungar
Keyword(s):  
Blood Pressure ◽  
Plasma Renin Activity ◽  
Sodium Intake ◽  
Renal Hypertension ◽  
Plasma Renin ◽  
Renin Activity ◽  
Prostaglandin E ◽  
Sodium Restriction ◽  
Arterial Plasma ◽  
Venous Plasma

1. Hypertension was induced in dogs by partial occulsion of one renal artery, the opposite kidney remaining intact, and the changes in blood pressure, plasma renin activity, aldosterone and prostaglandin E (PGE) were monitored. 2. Two days after induction of hypertension, the retained sodium and water were removed by haemodialysis and the animals were then maintained on a low dietary intake of sodium for the following 7 days. 3. Removal of the accumulated sodium and water had no immediate effect on blood pressure, but during the ensuing 7 days there was a small decrease in blood pressure, which again increased after re-institution of a normal sodium intake. 4. Plasma renin activity and aldosterone increased during development of hypertension and remained elevated during the period of sodium restriction. 5. Sodium and water retained during the development of hypertension was not responsible for the elevated blood pressure. 6. The concentration of PGE in arterial plasma and renal venous plasma from the undamped kidney were unchanged during the study, although we have previously shown that in the absence of sodium depletion, PGE rises. 7. PGE released from the kidney may be important in mediating the excretion of sodium and water that is retained during the development of renal hypertension.

Changes in the Renin-Angiotensin-Aldosterone System and in Sodium and Potassium Balance during Development of Renal Hypertension in Rats

1975 ◽  
Vol 48 (1) ◽  
pp. 17-26 ◽  
Author(s):  
F. H. H. Leenen ◽  
J. W. Scheeren ◽  
D. Omylanowski ◽  
J. D. Elema ◽  
B. Van Der Wal ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Plasma Renin Activity ◽  
Systolic Blood Pressure ◽  
Renal Hypertension ◽  
Plasma Renin ◽  
Renin Activity ◽  
Hypertensive Rats ◽  
Potassium Balance ◽  
Peripheral Plasma ◽  
Sodium And Potassium

1. The relationships between the renin-angiotensin-aldosterone system, sodium and potassium balance and systolic blood pressure were studied during development of moderate (160–180 mmHg; clip i.d. 0.25 mm) and severe (200–230 mmHg; clip i.d. 0.20 mm) renal hypertension in rats with an undisturbed contralateral kidney. 2. In severely hypertensive rats renin activity in the peripheral plasma increased from day 9, by which time the systolic blood pressure was elevated to 160–180 mmHg. The rate of total corticosteroid and aldosterone production in vitro increased from day 14 and plasma renin substrate concentration increased from day 24. In moderately hypertensive rats, none of these changes occurred. 3. During the first 10 days after the application of 0.25 and 0.20 mm clips, sodium and potassium retention/g gain in body weight were higher than in sham-operated controls. During the next 10 days, the positive balance stabilized in animals with a 0.25 mm clip whereas, in animals with a 0.20 mm clip, sodium and potassium balance returned to the level of the sham-operated controls through increased renal losses. Despite these changes the systolic pressure rose further in animals with a 0.20 mm clip. 4. The initial sodium retention could be a factor in the early rise of blood pressure and could account for the delay in the rise of peripheral plasma renin activity. The subsequent loss of the retained sodium and potassium during the development of severe hypertension could have facilitated the rise in peripheral plasma renin activity, but did not initiate this rise.

Alpha 1-adrenoceptor blockade in renal hypertensive rats with low and high renin levels

1984 ◽  
Vol 246 (4) ◽  
pp. H573-H578
Author(s):  
B. Waeber ◽  
J. Nussberger ◽  
H. R. Brunner
Keyword(s):  
Blood Pressure ◽  
Plasma Renin Activity ◽  
Renal Hypertension ◽  
Plasma Renin ◽  
Renin Activity ◽  
Plasma Norepinephrine ◽  
Hypertensive Rats ◽  
Blood Pressure Elevation ◽  
Significant Difference ◽  
Renal Hypertensive Rats

A total of 75 male Wistar rats with one-kidney, one-clip renal hypertension was maintained on either a regular (RNa) or a low-salt (LNa) diet for 3 wk after clipping. Blood pressure in the unanesthetized rats was equally elevated independent of sodium intake. Plasma renin activity was higher in LNa animals, and blood pressure was renin dependent only in this group, as evidenced by the blood pressure response to 10 mg/kg captopril iv. There was no significant difference in plasma catecholamines between RNa and LNa rats, although in the former the sympathetic nervous system is believed to play a major role in sustaining high blood pressure. The acute intravenous administration of 0.5 mg/kg prazosin did not induce a more pronounced blood pressure fall in the RNa rats. Prazosin enhanced plasma norepinephrine levels similarly in both groups, but epinephrine levels only rose in the LNa animals. Prazosin also markedly stimulated plasma renin activity rendering blood pressure renin dependent even in RNa rats. Thus, using alpha 1-adrenoceptor blockade, it has not been possible to demonstrate that the blood pressure elevation of salt-repleted one-kidney, one-clip renal hypertensive rats is due to an enhanced sympathetic nerve activity. Data obtained with sympatholytic agents must be interpreted with great caution if renin activity cannot be kept unchanged.

Effect of salt depletion and propranolol on blood pressure and plasma renin activity in various forms of hypertension.

1975 ◽  
Vol 36 (6) ◽  
pp. 248-256 ◽  
Author(s):  
G G Geyskes ◽  
P Boer ◽  
J Vos ◽  
F H Leenen ◽  
E J Mees
Keyword(s):  
Blood Pressure ◽  
Plasma Renin Activity ◽  
Plasma Renin ◽  
Renin Activity ◽  
Salt Depletion

Enhancement of the Antihypertensive Effect of Hydrochlorothiazide in Dogs after Suppression of Renin Release by Beta-Adrenergic Blockade

1975 ◽  
Vol 48 (2) ◽  
pp. 147-151
Author(s):  
C. S. Sweet ◽  
M. Mandradjieff
Keyword(s):  
Blood Pressure ◽  
Plasma Renin Activity ◽  
Arterial Blood Pressure ◽  
Antihypertensive Effect ◽  
Plasma Renin ◽  
Renin Activity ◽  
Renin Release ◽  
Antihypertensive Activity ◽  
Adrenergic Blockade ◽  
Arterial Blood

1. Renal hypertensive dogs were treated with hydrochlorothiazide (8−2 μmol/kg or 33 μmol/kg daily for 7 days), or timolol (4.6 μmol/kg daily for 4 days), a potent β-adrenergic blocking agent, or combinations of these drugs). Changes in mean arterial blood pressure and plasma renin activity were measured over the treatment period. 2. Neither drug significantly lowered arterial blood pressure when administered alone. Plasma renin activity, which did not change during treatment with timolol, was substantially elevated during treatment with hydrochlorothiazide. 3. When timolol was administered concomitantly with hydrochlorothiazide, plasma renin activity was suppressed and blood pressure was significantly lowered. 4. These observations suggest that compensatory activation of the renin-angiotensin system limits the antihypertensive activity of hydrochlorothiazide in renal hypertensive dogs and suppression of diuretic-induced renin release by timolol unmasks the antihypertensive effect of the diuretic.

PLASMA RENIN ACTIVITY, BLOOD PRESSURE AND SODIUM EXCRETION DURING TREATMENT WITH CLONIDINE

2009 ◽  
Vol 197 (1-6) ◽  
pp. 457-461 ◽  
Author(s):  
F. Fyhrquist ◽  
K. Kurppa ◽  
M. Huuskonen
Keyword(s):  
Blood Pressure ◽  
Plasma Renin Activity ◽  
Sodium Excretion ◽  
Plasma Renin ◽  
Renin Activity

Oral Contraceptives and Responsiveness of Plasma Renin Activity and Blood Pressure in Normotensive Women

1980 ◽  
Vol 2 (2) ◽  
pp. 197-211 ◽  
Author(s):  
Frans H. H. Leenen ◽  
Peter Boer ◽  
Evert J. Dorhout Mees
Keyword(s):  
Blood Pressure ◽  
Plasma Renin Activity ◽  
Oral Contraceptives ◽  
Plasma Renin ◽  
Renin Activity

scholarly journals Race, Plasma Renin Activity, and Morning Blood Pressure Surge--Results From the Dietary Approaches to Stop Hypertension Trial

2013 ◽  
Vol 27 (4) ◽  
pp. 530-536 ◽  
Author(s):  
F. R. Mc Causland ◽  
C. J. McMullan ◽  
F. M. Sacks ◽  
J. P. Forman
Keyword(s):  
Blood Pressure ◽  
Plasma Renin Activity ◽  
Plasma Renin ◽  
Renin Activity ◽  
Morning Blood Pressure Surge ◽  
Morning Blood Pressure ◽  
Pressure Surge
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