Effect of salt depletion and propranolol on blood pressure and plasma renin activity in various forms of hypertension.

1. Renal hypertensive dogs were treated with hydrochlorothiazide (8−2 μmol/kg or 33 μmol/kg daily for 7 days), or timolol (4.6 μmol/kg daily for 4 days), a potent β-adrenergic blocking agent, or combinations of these drugs). Changes in mean arterial blood pressure and plasma renin activity were measured over the treatment period. 2. Neither drug significantly lowered arterial blood pressure when administered alone. Plasma renin activity, which did not change during treatment with timolol, was substantially elevated during treatment with hydrochlorothiazide. 3. When timolol was administered concomitantly with hydrochlorothiazide, plasma renin activity was suppressed and blood pressure was significantly lowered. 4. These observations suggest that compensatory activation of the renin-angiotensin system limits the antihypertensive activity of hydrochlorothiazide in renal hypertensive dogs and suppression of diuretic-induced renin release by timolol unmasks the antihypertensive effect of the diuretic.

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PLASMA RENIN ACTIVITY, BLOOD PRESSURE AND SODIUM EXCRETION DURING TREATMENT WITH CLONIDINE

Acta Medica Scandinavica ◽

10.1111/j.0954-6820.1975.tb04951.x ◽

2009 ◽

Vol 197 (1-6) ◽

pp. 457-461 ◽

Cited By ~ 12

Author(s):

F. Fyhrquist ◽

K. Kurppa ◽

M. Huuskonen

Keyword(s):

Blood Pressure ◽

Plasma Renin Activity ◽

Sodium Excretion ◽

Plasma Renin ◽

Renin Activity

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Oral Contraceptives and Responsiveness of Plasma Renin Activity and Blood Pressure in Normotensive Women

Clinical and Experimental Hypertension ◽

10.3109/10641968009046420 ◽

1980 ◽

Vol 2 (2) ◽

pp. 197-211 ◽

Cited By ~ 3

Author(s):

Frans H. H. Leenen ◽

Peter Boer ◽

Evert J. Dorhout Mees

Keyword(s):

Blood Pressure ◽

Plasma Renin Activity ◽

Oral Contraceptives ◽

Plasma Renin ◽

Renin Activity

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Race, Plasma Renin Activity, and Morning Blood Pressure Surge--Results From the Dietary Approaches to Stop Hypertension Trial

American Journal of Hypertension ◽

10.1093/ajh/hpt031 ◽

2013 ◽

Vol 27 (4) ◽

pp. 530-536 ◽

Cited By ~ 3

Author(s):

F. R. Mc Causland ◽

C. J. McMullan ◽

F. M. Sacks ◽

J. P. Forman

Keyword(s):

Blood Pressure ◽

Plasma Renin Activity ◽

Plasma Renin ◽

Renin Activity ◽

Morning Blood Pressure Surge ◽

Morning Blood Pressure ◽

Pressure Surge

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Relationships between blood pressure, age, plasma renin activity and electrolyte excretion in normotensive subjects

Scandinavian Journal of Clinical and Laboratory Investigation ◽

10.3109/00365517709101841 ◽

1977 ◽

Vol 37 (6) ◽

pp. 521-528 ◽

Cited By ~ 42

Author(s):

Bengt E. Karlberg ◽

Kerstin Tolagen

Keyword(s):

Blood Pressure ◽

Plasma Renin Activity ◽

Plasma Renin ◽

Renin Activity ◽

Electrolyte Excretion ◽

Normotensive Subjects

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Effect of enalapril (MK-421), an orally active angiotensin I converting enzyme inhibitor, on blood pressure, active and inactive plasma renin, urinary prostaglandin E2, and kallikrein excretion in conscious rats

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y84-019 ◽

1984 ◽

Vol 62 (1) ◽

pp. 116-123 ◽

Cited By ~ 15

Author(s):

Ernesto L. Schiffrin ◽

Jolanta Gutkowska ◽

Gaétan Thibault ◽

Jacques Genest

Keyword(s):

Blood Pressure ◽

Angiotensin Ii ◽

Plasma Renin Activity ◽

Plasma Renin ◽

Ace Inhibition ◽

Renin Activity ◽

Prostaglandin E ◽

Converting Enzyme ◽

Angiotensin I ◽

Angiotensin I Converting Enzyme

The angiotensin I converting enzyme (ACE) inhibitor enalapril (MK-421), at a dose of 1 mg/kg or more by gavage twice daily, effectively inhibited the pressor response to angiotensin I for more than 12 h and less than 24 h. Plasma renin activity (PRA) did not change after 2 or 4 days of treatment at 1 mg/kg twice daily despite effective ACE inhibition, whereas it rose significantly at 10 mg/kg twice daily. Blood pressure fell significantly and heart rate increased in rats treated with 10 mg/kg of enalapril twice daily, a response which was abolished by concomitant angiotensin II infusion. However, infusion of angiotensin II did not prevent the rise in plasma renin. Enalapril treatment did not change urinary immunorcactive prostaglandin E2 (PGE2) excretion and indomethacin did not modify plasma renin activity of enalapril-treated rats. Propranolol significantly reduced the rise in plasma renin in rats receiving enalapril. None of these findings could be explained by changes in the ratio of active and inactive renin. Water diuresis, without natriuresis and with a decrease in potassium urinary excretion, occurred with the higher dose of enalapril. Enalapril did not potentiate the elevation of PRA in two-kidney one-clip Goldblatt hypertensive rats. In conclusion, enalapril produced renin secretion, which was in part β-adrenergically mediated. The negative short feedback loop of angiotensin II and prostaglandins did not appear to be involved. A vasodilator effect, apparently independent of ACE inhibition, was found in intact conscious sodium-replete rats.

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Effect of alcohol withdrawal on blood pressure, plasma renin activity, aldosterone, cortisol and dopamine β-hydroxylase

Clinical Science ◽

10.1042/cs0660659 ◽

1984 ◽

Vol 66 (6) ◽

pp. 659-663 ◽

Cited By ~ 55

Author(s):

L. T. Bannan ◽

J. F. Potter ◽

D. G. Beevers ◽

J. B. Saunders ◽

J. R. F. Walters ◽

...

Keyword(s):

Blood Pressure ◽

Plasma Renin Activity ◽

Alcohol Withdrawal ◽

Diastolic Pressure ◽

Urine Volume ◽

Plasma Renin ◽

Renin Activity ◽

Withdrawal Symptoms ◽

Urinary Volume ◽

Blood Pressures

1. Sixty-five alcoholic patients admitted for detoxification had blood pressure, withdrawal symptoms, plasma cortisol (PC) and plasma aldosteron (PA) levels, plasma renin activity (PRA), and serum dopamin β-hydroxylase (DBH) levels measured on the first and fourth days after admission. 2. On the morning after admission blood pressure was elevated (>140/90) in 32 patients (49%) and was 160/95mmHg or more in 21 (32%). PRA was initially elevated in 41 patients, PA levels in 14, and 13 patients had raised PC levels. By the fourth day, blood pressure and bio-chemical measures had fallen significantly while urine volume and sodium output, low on admission, had increased significantly. On admission urinary metanephrine levels were raised in four out of the 31 patients who had them measured. 3. The height of both the systolic and diastolic blood pressures was significantly related to the severity of the alcohol. withdrawal symptoms. Of the biochemical parameters measured, PC level correlated with systolic but not diastolic pressure, and urinary volume was inversely correlated with the height of the diastolic pressure. No relationship was found between blood pressure and PRA or PA level. 4. The pressor effect of alcohol withdrawal could be due to sympathetic nervous system overactivity, or possibly to hypercortisolaemia. The first hypothesis seems more likely.

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Solitary Kidney and Ageing as Causes of Low Renin and Aldosterone Concentrations: Relevance to ‘Low-Renin’ Essential Hypertension

Clinical Science ◽

10.1042/cs051177s ◽

1976 ◽

Vol 51 (s3) ◽

pp. 177s-180s ◽

Cited By ~ 1

Author(s):

R. Gordon ◽

Freda Doran ◽

M. Thomas ◽

Frances Thomas ◽

P. Cheras

Keyword(s):

Blood Pressure ◽

Essential Hypertension ◽

Plasma Renin Activity ◽

Plasma Volume ◽

Plasma Renin ◽

Renin Activity ◽

Dietary Sodium ◽

Sodium Restriction ◽

Normotensive Subjects ◽

The Mean

1. As experimental models of reduced nephron population in man, (a) twelve men aged 15–32 years who had one kidney removed 1–13 years previously and (b) fourteen normotensive men aged 70–90 years were studied. Results were compared with those in eighteen normotensive men aged 18–28 years and eleven men aged 19–33 years with essential hypertension. 2. While the subjects followed a routine of normal diet and daily activity, measurements were made, after overnight recumbency and in the fasting state, of plasma volume and renin activity on one occasion in hospital and of blood pressure on five to fourteen occasions in the home. Blood pressure was also measured after standing for 2 min and plasma renin activity after 1 h standing, sitting or walking. Twenty-four hour urinary aldosterone excretion was also measured. 3. The measurements were repeated in the normotensive subjects and subjects in (a) and (b) above after 10 days of sodium-restricted diet (40 mmol of sodium/day). 4. The mean plasma renin activity (recumbent) in essential hypertensive subjects was higher than in normotensive subjects. In subjects of (a) and (b) above, it was lower than normotensive subjects, and was not increased by dietary sodium restriction in subjects of (a). 5. The mean aldosterone excretion level was lower in old normotensive subjects than in the other groups, and increased in each group after dietary sodium restriction. 6. Mean plasma volume/surface area was not different between the four groups and in normotensive, essential hypertensive and nephrectomized subjects but not subjects aged 70–90 years was negatively correlated with standing diastolic blood pressure.

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