Effects of isometric leg training on ambulatory blood pressure and morning blood pressure surge in young normotensive men and women

Despite the reported association between diurnal variations in ambulatory blood pressure (BP) and elevated cardiovascular disease risk, little is known regarding the effects of isometric resistance training (IRT), a practical BP-lowering intervention, on ambulatory BP and morning BP surge (MBPS). Thus, we investigated whether (i) IRT causes reductions in ambulatory BP and MBPS, in young normotensives, and (ii) if there are any sex differences in these changes. Twenty normotensive individuals (mean 24-h SBP = 121 ± 7, DBP = 67 ± 6 mmHg) undertook 10-weeks of bilateral-leg IRT (4 × 2-min/2-min rest, at 20% maximum voluntary contraction (MVC) 3 days/week). Ambulatory BP and MBPS (mean systolic BP (SBP) 2 h after waking minus the lowest sleeping 1 h mean SBP) was measures pre- and post-training. There were significant reductions in 24-h ambulatory SBP in men (− 4 ± 2 mmHg, P = 0.0001) and women (− 4 ± 2 mmHg, P = 0.0001) following IRT. Significant reductions were also observed in MBPS (− 6 ± 8 mmHg, p = 0.044; − 6 ± 7 mmHg, P = 0.019), yet there were no significant differences between men and women in these changes, and 24-h ambulatory diastolic BP remained unchanged. Furthermore, a significant correlation was identified between the magnitude of the change in MBPS and the magnitude of changes in the mean 2-h SBP after waking for both men and women (men, r = 0.89, P = 0.001; women, r = 0.74, P = 0.014). These findings add further support to the idea that IRT, as practical lifestyle intervention, is effective in significantly lowering ambulatory SBP and MBPS and might reduce the incidence of adverse cardiovascular events that often occur in the morning.

Morning blood pressure surge in the early stage of hypertensive patients impacts three-dimensional left ventricular speckle tracking echocardiography

Background The aim of this study was to examine left ventricular (LV) function in untreated, newly diagnosed hypertensive patients with morning blood pressure surge (MBPS) status using three-dimensional (3D) speckle tracking echocardiography (STE). Methods In this study, 163 newly diagnosed hypertensive patients were included, and all patients underwent 24-h ambulatory blood pressure monitoring (ABPM). According to ABPM, participants were divided into a MBPS group and a non-MBPS group. The entire study population was examined by complete two-dimensional (2D) transthoracic echocardiography (TTE) and 3D STE. Result The results of this study showed that 3D LV longitudinal strain was significantly decreased in the MBPS group compared with the non-MBPS group (− 30.1 ± 2.0 vs. -31.1 ± 2.7, p = 0.045). Similar trends were observed for 3D twist (9.6 ± 6.1 vs. 12.1 ± 4.8, p = 0.011) as well as for 3D torsion (1.23 ± 0.78 vs. 1.49 ± 0.62, p = 0.042). The LV principal strain was decreased in the MBPS group (− 33.9 ± 1.7 vs. -35.5 ± 2.8, p < 0.001). The 3D LV global longitudinal strain (GLS) and principal strain were significantly associated with quartile of MBPS as measured by systolic blood pressure (SBP). Conclusion The 3D STE revealed that LV mechanics were more impaired in the MBPS group than in the non-surge newly diagnosed, untreated hypertensive patients; even the 2D TTE parameters showed no difference.

LNG Loading Lines High Surge Analysis

Proper design of LNG loading lines and verification of emergency shutdown (ESD) interlock systems are critical in ensuring overall safety of the LNG facility. During an emergency, ESD interlock is activated with ESD valves closure initiated simultaneously with all loading pumps trip and the kickback valves open. During the ESD valves closure, the pipeline can be exposed to a risk of high surge pressures exerted onto the wall. A pressure surge or liquid hammering phenomenon in piping systems can be caused by a fluid in motion forced to stop or change direction suddenly (rapid momentum change) and also due to cavitation effect. Cavitation is caused by the formation and instantaneous collapse of vapour bubbles. The collapsing bubbles exert severe localized impact forces that can result in pressure surges. This paper discusses the methodology used to evaluate any potential occurrence of surge and the peak pressure associated with it, using several case studies for analysis. This paper also shares best practice identified from the study to facilitate with safe operations at an LNG loading facility.

Laboratory Evidence of Transient Pressure Surge in a Fluid-Filled Fracture as a Potential Driver of Remote Dynamic Earthquake Triggering

Seismic waves carrying tiny perturbing stresses can trigger earthquakes in geothermal and volcanic regions. The underlying cause of this dynamic triggering is still not well understood. One leading hypothesis is that a sudden increase in the fluid-pore pressure in the fault zone is involved, but the exact physical mechanism is unclear. Here, we report experimental evidence in which a fluid-filled fracture was shown to be able to amplify the pressure of an incoming seismic wave. We built miniature pressure sensors and directly placed them inside a thin fluid-filled fracture to measure the fluid pressure during wave propagation. By varying the fracture aperture from 0.2 to 9.2 mm and sweeping the frequency from 12 to 70 Hz, we observed in the lab that the fluid pressure in the fracture could be amplified up to 25.2 times compared with the incident-wave amplitude. Because an increase of the fluid pressure in a fault can reduce the effective normal stress to allow the fault to slide, our observed transient pressure surge phenomenon may provide the mechanism for earthquake dynamic triggering.