The role of oxygen-derived free radicals in two models of experimental acute pancreatitis: Effects of catalase, superoxide dismutase, dimethylsulfoxide, and allopurinol

We previously showed [ Am. J. Physiol. 272 ( Heart Circ. Physiol. 41): H2337–H2342, 1997] that nicotine impairs endothelium-dependent arteriolar dilatation. However, mechanisms that accounted for the effect of nicotine on endothelium-dependent vasodilatation were not examined. Thus the goal of this study was to examine the role of oxygen radicals in nicotine-induced impairment of arteriolar reactivity. We measured diameter of cheek pouch resistance arterioles (∼50 μm diameter) in response to endothelium-dependent (ACh and ADP) and -independent (nitroglycerin) agonists before and after infusion of vehicle or nicotine in the absence or presence of superoxide dismutase. ACh, ADP, and nitroglycerin produced dose-related dilatation of cheek pouch arterioles before infusion of vehicle or nicotine. Infusion of vehicle, in the absence or presence of superoxide dismutase (150 U/ml), did not alter endothelium-dependent or -independent arteriolar dilatation. In contrast, infusion of nicotine (2 μg ⋅ kg−1 ⋅ min−1) impaired endothelium-dependent, but not -independent, arteriolar dilatation. In addition, the effect of nicotine on endothelium-dependent vasodilatation was reversed by topical application of superoxide dismutase. We suggest that nicotine impairs endothelium-dependent arteriolar dilatation via an increase in the synthesis/release of oxygen-derived free radicals.

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Evidence for a role of oxygen derived free radicals in the pathogenesis of caerulein induced acute pancreatitis in rats.

Gut ◽

10.1136/gut.29.11.1516 ◽

1988 ◽

Vol 29 (11) ◽

pp. 1516-1523 ◽

Cited By ~ 75

Author(s):

J Wisner ◽

D Green ◽

L Ferrell ◽

I Renner

Keyword(s):

Acute Pancreatitis ◽

Free Radicals ◽

Oxygen Derived Free Radicals

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The role of oxygen-derived free radicals in acute pancreatitis

Gastroenterology ◽

10.1016/s0016-5085(98)81786-1 ◽

1998 ◽

Vol 114 ◽

pp. A442

Author(s):

J. Bilski ◽

A. Szlachcic ◽

J. Jaworek ◽

M. Cieszkowski ◽

A. Dembiński ◽

...

Keyword(s):

Acute Pancreatitis ◽

Free Radicals ◽

Oxygen Derived Free Radicals

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The role of oxygen free radicals in experimental acute pancreatitis in the rat

International Journal of Gastrointestinal Cancer ◽

10.1007/bf02924414 ◽

1989 ◽

Vol 5 (2) ◽

pp. 135-143 ◽

Cited By ~ 3

Author(s):

Toshihiko Koiwai ◽

Hisao Oguchi ◽

Shigeyuki Kawa ◽

Yasutoshi Yanagisawa ◽

Takeshi Kobayashi ◽

...

Keyword(s):

Acute Pancreatitis ◽

Free Radicals ◽

Oxygen Free Radicals ◽

Experimental Acute Pancreatitis

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The role of the liver in the development of respiratory failure in experimental acute pancreatitis (AP)

HPB ◽

10.1016/j.hpb.2016.02.838 ◽

2016 ◽

Vol 18 ◽

pp. e324-e325

Author(s):

P. Miguel ◽

J. Camelione ◽

L. Cardozo Bidart ◽

R. Trapani ◽

P. Curvale ◽

...

Keyword(s):

Acute Pancreatitis ◽

Respiratory Failure ◽

Experimental Acute Pancreatitis

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Organic Peroxy Free Radicals and the Role of Superoxide Dismutase and Antioxidants

Reactive Oxygen Species in Chemistry, Biology, and Medicine ◽

10.1007/978-1-4757-0417-4_5 ◽

1988 ◽

pp. 81-84

Author(s):

R. L. Willson

Keyword(s):

Superoxide Dismutase ◽

Free Radicals

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Oxidative Stress in Critically Ill Patients

American Journal of Critical Care ◽

10.4037/ajcc2002.11.6.543 ◽

2002 ◽

Vol 11 (6) ◽

pp. 543-551 ◽

Cited By ~ 83

Author(s):

Caryl Goodyear-Bruch ◽

Janet D. Pierce

Keyword(s):

Oxidative Stress ◽

Reactive Oxygen Species ◽

Superoxide Dismutase ◽

Free Radicals ◽

Critically Ill ◽

Critically Ill Patients ◽

Oxygen Free Radicals ◽

Oxygen Species ◽

Defense System ◽

Oxygen Derived Free Radicals

Oxygen-derived free radicals play an important role in the development of disease in critically ill patients. Normally, oxygen free radicals are neutralized by antioxidants such as vitamin E or enzymes such as superoxide dismutase. However, in patients who require intensive care, oxygen free radicals become a problem when either a decrease in the removal or an overproduction of the radicals occurs. This oxidative stress and the damage due to it have been implicated in many diseases in critically ill patients. Many drugs and treatments now being investigated are directed toward preventing the damage from oxidative stress. The formation of reactive oxygen species, the damage caused by them, and the body’s defense system against them are reviewed. New interventions are described that may be used in critically ill patients to prevent or treat oxidative damage.

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