The role of oxygen-derived free radicals in two models of experimental acute pancreatitis: Effects of catalase, superoxide dismutase, dimethylsulfoxide, and allopurinol

1991 ◽  
Vol 69 (21-23) ◽  
pp. 1012-1017 ◽  
Author(s):  
M. L. Steer ◽  
P. L. Rutledge ◽  
R. E. Powers ◽  
M. Saluja ◽  
A. K. Saluja
Keyword(s):  
Acute Pancreatitis ◽  
Superoxide Dismutase ◽  
Free Radicals ◽  
Experimental Acute Pancreatitis ◽  
Oxygen Derived Free Radicals

scholarly journals The Role of Oxygen-derived Free Radicals in the Pathogenesis of Acute Pancreatitis

1984 ◽  
Vol 200 (4) ◽  
pp. 405-413 ◽  
Author(s):  
HILARY SANFEY ◽  
GREGORY B. BULKLEY ◽  
JOHN L. CAMERON
Keyword(s):  
Acute Pancreatitis ◽  
Free Radicals ◽  
Oxygen Derived Free Radicals

Superoxide dismutase restores endothelium-dependent arteriolar dilatation during acute infusion of nicotine

1998 ◽  
Vol 85 (4) ◽  
pp. 1292-1298 ◽  
Author(s):  
William G. Mayhan ◽  
Glenda M. Sharpe
Keyword(s):  
Superoxide Dismutase ◽  
Free Radicals ◽  
Topical Application ◽  
Oxygen Radicals ◽  
Cheek Pouch ◽  
Oxygen Derived Free Radicals ◽  
Before And After

We previously showed [ Am. J. Physiol. 272 ( Heart Circ. Physiol. 41): H2337–H2342, 1997] that nicotine impairs endothelium-dependent arteriolar dilatation. However, mechanisms that accounted for the effect of nicotine on endothelium-dependent vasodilatation were not examined. Thus the goal of this study was to examine the role of oxygen radicals in nicotine-induced impairment of arteriolar reactivity. We measured diameter of cheek pouch resistance arterioles (∼50 μm diameter) in response to endothelium-dependent (ACh and ADP) and -independent (nitroglycerin) agonists before and after infusion of vehicle or nicotine in the absence or presence of superoxide dismutase. ACh, ADP, and nitroglycerin produced dose-related dilatation of cheek pouch arterioles before infusion of vehicle or nicotine. Infusion of vehicle, in the absence or presence of superoxide dismutase (150 U/ml), did not alter endothelium-dependent or -independent arteriolar dilatation. In contrast, infusion of nicotine (2 μg ⋅ kg−1 ⋅ min−1) impaired endothelium-dependent, but not -independent, arteriolar dilatation. In addition, the effect of nicotine on endothelium-dependent vasodilatation was reversed by topical application of superoxide dismutase. We suggest that nicotine impairs endothelium-dependent arteriolar dilatation via an increase in the synthesis/release of oxygen-derived free radicals.

scholarly journals Evidence for a role of oxygen derived free radicals in the pathogenesis of caerulein induced acute pancreatitis in rats.

Gut ◽  
1988 ◽  
Vol 29 (11) ◽  
pp. 1516-1523 ◽  
Author(s):  
J Wisner ◽  
D Green ◽  
L Ferrell ◽  
I Renner
Keyword(s):  
Acute Pancreatitis ◽  
Free Radicals ◽  
Oxygen Derived Free Radicals

The role of oxygen-derived free radicals in acute pancreatitis

1998 ◽  
Vol 114 ◽  
pp. A442
Author(s):  
J. Bilski ◽  
A. Szlachcic ◽  
J. Jaworek ◽  
M. Cieszkowski ◽  
A. Dembiński ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Free Radicals ◽  
Oxygen Derived Free Radicals

The role of oxygen free radicals in experimental acute pancreatitis in the rat

1989 ◽  
Vol 5 (2) ◽  
pp. 135-143 ◽  
Author(s):  
Toshihiko Koiwai ◽  
Hisao Oguchi ◽  
Shigeyuki Kawa ◽  
Yasutoshi Yanagisawa ◽  
Takeshi Kobayashi ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Free Radicals ◽  
Oxygen Free Radicals ◽  
Experimental Acute Pancreatitis

scholarly journals The role of the liver in the development of respiratory failure in experimental acute pancreatitis (AP)

HPB ◽  
2016 ◽  
Vol 18 ◽  
pp. e324-e325
Author(s):  
P. Miguel ◽  
J. Camelione ◽  
L. Cardozo Bidart ◽  
R. Trapani ◽  
P. Curvale ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Respiratory Failure ◽  
Experimental Acute Pancreatitis

Oxidative Stress in Critically Ill Patients

2002 ◽  
Vol 11 (6) ◽  
pp. 543-551 ◽  
Author(s):  
Caryl Goodyear-Bruch ◽  
Janet D. Pierce
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Superoxide Dismutase ◽  
Free Radicals ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Oxygen Free Radicals ◽  
Oxygen Species ◽  
Defense System ◽  
Oxygen Derived Free Radicals

Oxygen-derived free radicals play an important role in the development of disease in critically ill patients. Normally, oxygen free radicals are neutralized by antioxidants such as vitamin E or enzymes such as superoxide dismutase. However, in patients who require intensive care, oxygen free radicals become a problem when either a decrease in the removal or an overproduction of the radicals occurs. This oxidative stress and the damage due to it have been implicated in many diseases in critically ill patients. Many drugs and treatments now being investigated are directed toward preventing the damage from oxidative stress. The formation of reactive oxygen species, the damage caused by them, and the body’s defense system against them are reviewed. New interventions are described that may be used in critically ill patients to prevent or treat oxidative damage.

Elucidating the role of oxidative stress in the therapeutic effect of rutin on experimental acute pancreatitis

2016 ◽  
Vol 50 (12) ◽  
pp. 1350-1360 ◽  
Author(s):  
Fabíula Francisca Abreu ◽  
Ana Carla Araújo Souza ◽  
Simone Aparecida Teixeira ◽  
Antônio Garcia Soares ◽  
Daiane Franco Teixeira ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Pancreatitis ◽  
Therapeutic Effect ◽  
Experimental Acute Pancreatitis
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