defense system
Recently Published Documents


TOTAL DOCUMENTS

2469
(FIVE YEARS 811)

H-INDEX

86
(FIVE YEARS 13)

Science ◽  
2022 ◽  
Vol 375 (6577) ◽  
pp. 221-225
Author(s):  
Alex G. Johnson ◽  
Tanita Wein ◽  
Megan L. Mayer ◽  
Brianna Duncan-Lowey ◽  
Erez Yirmiya ◽  
...  

Ancient origin of cell death Gasdermins are cell death proteins in mammals that form membrane pores in response to pathogen infection. Johnson et al . report that diverse bacteria encode structural and functional homologs of mammalian gasdermins. Like their mammalian counterparts, bacterial gasdermins are activated by caspase-like proteases, oligomerize into large membrane pores, and defend against pathogen—in this case, bacteriophage—infection. Proteolytic activation occurs through the release of a short inhibitory peptide, and many bacterial gasdermins are lipidated to facilitate membrane pore formation. Pyroptotic cell death, a central component of mammalian innate immunity, thus has a shared origin with an ancient antibacteriophage defense system. —SMH


2022 ◽  
Vol 12 ◽  
Author(s):  
Afsane Hosseini ◽  
Mojtaba Hosseini ◽  
Peter Schausberger

Plants mediate interactions between below- and above-ground microbial and animal communities. Microbial communities of the rhizosphere commonly include mutualistic symbionts such as mycorrhizal fungi, rhizobia and free-living plant growth-promoting rhizobacteria (PGPR) that may influence plant growth and/or its defense system against aboveground pathogens and herbivores. Here, we scrutinized the effects of three PGPR, Azotobacter chroococcum, Azospirillum brasilense, and Pseudomonas brassicacearum, on life history and population dynamics of two-spotted spider mites, Tetranychus urticae, feeding on aboveground tissue of strawberry plants, and examined associated plant growth and physiology parameters. Our experiments suggest that these three species of free-living rhizobacteria strengthen the constitutive, and/or induce the direct, anti-herbivore defense system of strawberry plants. All three bacterial species exerted adverse effects on life history and population dynamics of T. urticae and positive effects on flowering and physiology of whole strawberry plants. Spider mites, in each life stage and in total, needed longer time to develop on PGPR-treated plants and had lower immature survival rates than those fed on chemically fertilized and untreated plants. Reduced age-specific fecundity, longer developmental time and lower age-specific survival rates of mites feeding on rhizobacteria treated plants reduced their intrinsic rate of increase as compared to mites feeding on chemically fertilized and control plants. The mean abundance was lower in spider mite populations feeding on PGPR-treated strawberries than in those feeding on chemically fertilized and untreated plants. We argue that the three studied PGPR systemically strengthened and/or induced resistance in above-ground plant parts and enhanced the level of biochemical anti-herbivore defense. This was probably achieved by inducing or upregulating the production of secondary plant metabolites, such as phenolics, flavonoids and anthocyanins, which were previously shown to be involved in induced systemic resistance of strawberry plants. Overall, our study emphasizes that PGPR treatment can be a favorable strawberry plant cultivation measure because providing essential nutrients needed for proper plant growth and at the same time decreasing the life history performance and population growth of the notorious herbivorous pest T. urticae.


Author(s):  
R. Y. Sharykin

The article discusses the implementation in Java of the stochastic collaborative virus defense model developed within the framework of the Distributed Object-Based Stochastic Hybrid Systems (DOBSHS) model and its analysis. The goal of the work is to test the model in conditions close to the real world on the way to introducing its use in the practical environment. We propose a method of translating a system specification in the SHYMaude language, intended for the specification and analysis of DOBSHS models in the rewriting logic framework, into the corresponding Java implementation. The resulting Java system is deployed on virtual machines, the virus and the group virus alert system are modeled stochastically. To analyze the system we use several metrics, such as the saturation time of the virus propagation, the proportion of infected nodes upon reaching saturation and the maximal virus propagation speed. We use Monte Carlo method with the computation of confidence intervals to obtain estimates of the selected metrics. We perform analysis on the basis of the sigmoid virus propagation graph over time in the presence of the defense system. We implemented two versions of the system using two protocols for transmitting messages between nodes, TCP/IP and UDP. We measured the influence of the protocol type and the associated costs on the defense system effectiveness. To assess the potential of cost reduction associated with the use of different message transmission protocols, we performed analysis of the original DOBSHS model modified to model message transmission delays. We measured the influence of other model parameters important for the next steps towards the practical use of the model. To address the system scalability, we propose a hierarchical approach to the system design to make possible its use with a large number of nodes.


2022 ◽  
Vol 13 (3) ◽  
Author(s):  
Prem Lal Kashyap ◽  
Sudheer Kumar ◽  
Sumit Kumar Aggarwal ◽  
Noyonika Kaul ◽  
Poonam Jasrotia ◽  
...  

2022 ◽  
Vol 18 (1) ◽  
Author(s):  
Min-Jin Kwak ◽  
Sun-Woo Choi ◽  
Yong-Soon Choi ◽  
Hanbae Lee ◽  
Kwang-Youn Whang

Abstract Background In animals, weaning stress is the first and most critical stress. Weaning can negatively affect the growth performance of animals physically, psychologically, and pathologically. Our previous studies on the HT-29 cell line and early-weaned rats demonstrated that adequate sophorolipid (SPL) supplementation in feed could enhance the mucin-producing and wound healing capacities of the gut defense system by modulating gut microbiota. Methods We conducted an experiment with one hundred forty 21-day-old early weaned piglets (L x Y x D). They were allocated into 4 treatment and 7 replications (4 pigs per pen) according to their initial body weight. Body weight and feed intake were measured biweekly during experimental period. After 6 weeks, 28 pigs were randomly selected and sacrificed to collect plasma, jejunum, and cecal content samples. Results Dietary SPL supplementation at 5 and 10 mg/kg quadratically increased the average daily gain during the experimental period in the treatment groups when compared with the control group. The albumin levels of piglets fed with the SPL supplemented diet were downregulated to the normal range. Moreover, in feed, SPL supplementation at 5 and 10 mg/kg improved jejunal histological indices and gene expression levels related to mucin secretion and local inflammation markers. Consistent with these results, adequate SPL supplementation (5 and 10 mg/kg) increased the population of Prevotella, a beneficial bacterium, and its short-chain fatty acid production in the ceca of piglets. Conclusions The occurrence of diarrhea after weaning in piglets could be reduced by feeding a 10 ppm of SPL supplemented diet which improves the gut defense system by improving the microbial population and enhancing mucin layer integrity.


Sign in / Sign up

Export Citation Format

Share Document