Role of voltage-dependent calcium channels in secretion of calcitonin from human medullary thyroid carcinoma cells

1989 ◽  
Vol 67 (12) ◽  
pp. 635-639 ◽  
Author(s):  
F. Raue ◽  
H. Serve ◽  
A. Grauer ◽  
E. Rix ◽  
H. Scherübl ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Calcium Channels ◽  
Medullary Thyroid Carcinoma ◽  
Carcinoma Cells ◽  
Medullary Thyroid ◽  
Voltage Dependent ◽  
Voltage Dependent Calcium Channels

scholarly journals Mortalin (GRP75/HSPA9) upregulation promotes survival and proliferation of medullary thyroid carcinoma cells

Oncogene ◽  
2014 ◽  
Vol 34 (35) ◽  
pp. 4624-4634 ◽  
Author(s):  
D Starenki ◽  
S-K Hong ◽  
R V Lloyd ◽  
J-I Park
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Carcinoma Cells ◽  
Medullary Thyroid

The role of voltage-dependent calcium channels in angiotensin-stmulated glomerulosa cells

1996 ◽  
Vol 22 (4) ◽  
pp. 569-576 ◽  
Author(s):  
A. Spät ◽  
T. Rohács ◽  
A. Horváth ◽  
G Y. Szabadkai ◽  
P. Enyedi
Keyword(s):  
Calcium Channels ◽  
Voltage Dependent ◽  
Voltage Dependent Calcium Channels ◽  
Glomerulosa Cells

Ifenprodil reduces excitatory synaptic transmission by blocking presynaptic P/Q type calcium channels

2012 ◽  
Vol 107 (6) ◽  
pp. 1571-1575 ◽  
Author(s):  
Andrew J. Delaney ◽  
John M. Power ◽  
Pankaj Sah
Keyword(s):  
Calcium Channels ◽  
Synaptic Transmission ◽  
Nmda Receptors ◽  
Basolateral Amygdala ◽  
Excitatory Transmission ◽  
Voltage Dependent ◽  
Voltage Dependent Calcium Channels ◽  
P Type ◽  
Selective Blocker

Ifenprodil is a selective blocker of NMDA receptors that are heterodimers composed of GluN1/GluN2B subunits. This pharmacological profile has been extensively used to test the role of GluN2B-containing NMDA receptors in learning and memory formation. However, ifenprodil has also been reported to have actions at a number of other receptors, including high voltage-activated calcium channels. Here we show that, in the basolateral amygdala, ifenprodil dose dependently blocks excitatory transmission to principal neurons by a presynaptic mechanism. This action of ifenprodil has an IC50 of ∼10 μM and is fully occluded by the P/Q type calcium channel blocker ω-agatoxin. We conclude that ifenprodil reduces synaptic transmission in the basolateral amygdala by partially blocking P-type voltage-dependent calcium channels.

Role of 188Re(V)DMSA in the diagnosis and therapy of medullary thyroid carcinoma

1999 ◽  
Vol 20 (4) ◽  
pp. 398
Author(s):  
D. L. Learoyd ◽  
P. J. Roach ◽  
G. M. Snowdon ◽  
K. Dadachova ◽  
A. M. Moreau ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Medullary Thyroid ◽  
Diagnosis And Therapy

scholarly journals Calcitonin-Specific Transcription and Splicing Targets Gene-Directed Enzyme Prodrug Therapy to Medullary Thyroid Carcinoma Cells

2003 ◽  
Vol 88 (3) ◽  
pp. 1310-1318 ◽  
Author(s):  
Marinella Messina ◽  
Denise M. T. Yu ◽  
Gerald W. Both ◽  
Peter L. Molloy ◽  
Bruce G. Robinson
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Carcinoma Cells ◽  
Enzyme Prodrug Therapy ◽  
Medullary Thyroid

Abstract 2181: Tumor suppressor role of Notch3 in medullary thyroid carcinoma

2011 ◽  
Author(s):  
Renata Jaskula-Sztul ◽  
Jacob Eide ◽  
Muthusamy Kunnimalaiyaan ◽  
Herbert Chen
Keyword(s):  
Tumor Suppressor ◽  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Medullary Thyroid

scholarly journals The Role of Calcitonin in Predicting the Extent of Surgery in Medullary Thyroid Carcinoma: A Nationwide Population-Based Study in Norway

2019 ◽  
Vol 8 (3) ◽  
pp. 159-166 ◽  
Author(s):  
Else Marie Opsahl ◽  
Lars Andreas Akslen ◽  
Ellen Schlichting ◽  
Turid Aas ◽  
Katrin Brauckhoff ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Population Based ◽  
Population Based Study ◽  
Medullary Thyroid ◽  
Extent Of Surgery
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