Classification and biological distribution of histamine receptor sub-types

1994 ◽  
Vol 43 (3-4) ◽  
pp. 97-116 ◽  
Author(s):  
N. Chand ◽  
P. Eyre
Keyword(s):  
Histamine Receptor ◽  
Biological Distribution

Classification and biological distribution of histamine receptor sub-types

1975 ◽  
Vol 5 (4) ◽  
pp. 277-295 ◽  
Author(s):  
N. Chand ◽  
P. Eyre
Keyword(s):  
Histamine Receptor ◽  
Biological Distribution

scholarly journals HYBID (alias KIAA1199/CEMIP) and hyaluronan synthase coordinately regulate hyaluronan metabolism in histamine-stimulated skin fibroblasts

2020 ◽  
Vol 295 (8) ◽  
pp. 2483-2494
Author(s):  
Hiroyuki Yoshida ◽  
Mika Aoki ◽  
Aya Komiya ◽  
Yoko Endo ◽  
Keigo Kawabata ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Fold Increase ◽  
Histamine Receptor ◽  
Skin Fibroblasts ◽  
Dependent Manner ◽  
Skin Damage ◽  
Photoaged Skin ◽  
Molecular Sizes ◽  
Ha Synthase ◽  
Hyaluronan Binding

The immune-regulatory compound histamine is involved in the metabolism of the essential skin component hyaluronan (HA). We previously reported that histamine up-regulates the expression of HYBID (hyaluronan-binding protein involved in hyaluronan depolymerization, also called CEMIP or KIAA1199), which plays a key role in HA degradation. However, no information is available about histamine's effects on HA synthase (HAS) expression, the molecular sizes of HA species produced, and histamine receptors and their signaling pathways in skin fibroblasts. Moreover, histamine's effects on photoaged skin remain elusive. Here, we show that histamine increases HA degradation by up-regulating HYBID and down-regulating HAS2 in human skin fibroblasts in a dose- and time-dependent manner and thereby decreases the total amounts and sizes of newly produced HA. Histamine H1 blocker abrogated the histamine effects on HYBID up-regulation, HAS2 suppression, and HA degradation. Histamine H1 agonist exhibited effects on HA levels, composition, and breakdown similar to those of histamine. Of note, blockade of protein kinase Cδ or PI3K–Akt signaling abolished histamine-mediated HYBID stimulation and HAS2 suppression, respectively. Immunohistochemical experiments revealed a significant ∼2-fold increase in tryptase-positive mast cells in photoaged skin, where HYBID and HAS2 expression levels were increased and decreased, respectively, compared with photoprotected skin. These results indicate that histamine controls HA metabolism by up-regulating HYBID and down-regulating HAS2 via distinct signaling pathways downstream of histamine receptor H1. They further suggest that histamine may contribute to photoaged skin damage by skewing HA metabolism toward degradation.

scholarly journals H1-Histamine Receptor Affinity Predicts Short-Term Weight Gain for Typical and Atypical Antipsychotic Drugs

2003 ◽  
Vol 28 (3) ◽  
pp. 519-526 ◽  
Author(s):  
Wesley K Kroeze ◽  
Sandra J Hufeisen ◽  
Beth A Popadak ◽  
Sean M Renock ◽  
SeAnna Steinberg ◽  
...  
Keyword(s):  
Weight Gain ◽  
Atypical Antipsychotic ◽  
Antipsychotic Drugs ◽  
Histamine Receptor ◽  
Short Term ◽  
Receptor Affinity ◽  
Atypical Antipsychotic Drugs

The effect of pH on rabbit atrial response to histamine

1976 ◽  
Vol 54 (2) ◽  
pp. 118-127 ◽  
Author(s):  
M. J. Hughes ◽  
I. A. Coret
Keyword(s):  
Histamine Receptor ◽  
Maximum Response ◽  
Force Of Contraction ◽  
Histamine Concentration ◽  
Adenyl Cyclase Activity ◽  
Chronotropic Response ◽  
Spontaneous Rate ◽  
Histamine Response ◽  
Ph Range ◽  
Rabbit Atria

The chronotropic response of isolated rabbit atria in normal Tyrode's medium increases monotonically with increasing doses of histamine (9 × 10−7–9 × 10−4 M). Plots of the inverse of response against the inverse of concentration were linear; and from these plots were derived values for the theoretical maximum response at 'infinite' dose and for the histamine concentration required to evoke a half maximum response. Alteration of pH by changing [HCO3−] at constant pCO2, [Na+] and osmolality did not appreciably affect the response to histamine in the range pH 7.0–7.6. However, at pH below 7.0 the magnitude of histamine response was reduced at all concentrations of histamine tested. In the pH range 7.0–7.6, additions of NaHCO3 at constant pCO2 increased the spontaneous rate of rabbit atria (in the absence of histamine); however, there was little effect of changing pH (in this range) by altering [HCO3−] at constant pCO2 when [Na+] and osmolality were kept constant. Immersion in solutions at pH's less than 7.0 led to decline in spontaneous rate and force of contraction. It is probable that depression of adenyl cyclase activity rather than a specific change in ionization of histamine receptor is responsible for a decreased response to histamine at pH 6.9.

scholarly journals H3 histamine receptor antagonist pitolisant reverses some subchronic disturbances induced by olanzapine in mice

2016 ◽  
Vol 31 (5) ◽  
pp. 1023-1029 ◽  
Author(s):  
Magdalena Dudek ◽  
Kamil Kuder ◽  
Marcin Kołaczkowski ◽  
Adrian Olczyk ◽  
Elżbieta Żmudzka ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Histamine Receptor ◽  
Histamine Receptor Antagonist

389 Histamine Receptor Antagonists Added to PPIs Improve Gastric Acid Control When Taken Chronically

2012 ◽  
Vol 142 (5) ◽  
pp. S-86 ◽  
Author(s):  
Peter A. Naas ◽  
Christopher Rife ◽  
Paul Nietert ◽  
Donald O. Castell
Keyword(s):  
Gastric Acid ◽  
Histamine Receptor ◽  
Receptor Antagonists ◽  
Histamine Receptor Antagonists ◽  
Acid Control
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