Ileal absorption of bile acids in patients with chronic cholestasis

1996 ◽  
Vol 41 (12) ◽  
pp. 2417-2422 ◽  
Author(s):  
Olivier Chazouillères ◽  
Philippe Marteau ◽  
Mostefa Haniche ◽  
Raymond Jian ◽  
Raoul Poupon
Keyword(s):  
Bile Acids ◽  
Chronic Cholestasis ◽  
Ileal Absorption

Evaluation of the Ileal Absorption Capacity for Bile Acids in the Rabbit

1990 ◽  
Vol 22 (2) ◽  
pp. 93-100 ◽  
Author(s):  
R. Aldini ◽  
G. Ussia ◽  
A. Roda ◽  
Grilli Cilioni ◽  
R. Rizzoli ◽  
...  
Keyword(s):  
Bile Acids ◽  
Absorption Capacity ◽  
Ileal Absorption

Effect of cholestasis on ileal absorption of bile acids and on ileal bile acid transporter in rat

1998 ◽  
Vol 114 ◽  
pp. A1334
Author(s):  
P. Sauer ◽  
A. Stiehl ◽  
P. Kloeters-Plachky ◽  
BA Fitscher ◽  
HD Riedel ◽  
...  
Keyword(s):  
Bile Acid ◽  
Bile Acids ◽  
Bile Acid Transporter ◽  
Ileal Absorption ◽  
Acid Transporter

No influence of age on the ileal absorption of bile acids in humans as determined by the SeHCAT test

1993 ◽  
Vol 5 (4) ◽  
pp. 247-250 ◽  
Author(s):  
Sharif Eusufzai ◽  
Sverker Ericsson ◽  
Torsten Cederlund ◽  
Kurt Einarsson ◽  
Bo Angelin
Keyword(s):  
Bile Acids ◽  
Ileal Absorption

Ileal absorption of tyrosine-conjugated bile acids in Wistar rats

1987 ◽  
Vol 926 (2) ◽  
pp. 154-159 ◽  
Author(s):  
Charles O. Mills ◽  
Sajida Iqbal ◽  
Elwyn Elias
Keyword(s):  
Bile Acids ◽  
Wistar Rats ◽  
Ileal Absorption ◽  
Conjugated Bile Acids

scholarly journals FRI0573 Osteocytes are involved in the pathogenesis of osteoporosis in chronic cholestasis. effects of bilirubin and bile acids on osteocytic cell lines

2017 ◽  
Author(s):  
S Ruiz-Gaspà ◽  
A Parés ◽  
A Combalia ◽  
P Peris ◽  
A Monegal ◽  
...  
Keyword(s):  
Bile Acids ◽  
Cell Lines ◽  
Chronic Cholestasis

scholarly journals Inflammation and Cell Death During Cholestasis: The Evolving Role of Bile Acids

2019 ◽  
Vol 19 (3) ◽  
pp. 215-228 ◽  
Author(s):  
Benjamin L. Woolbright ◽  
Hartmut Jaeschke
Keyword(s):  
Cell Death ◽  
Liver Injury ◽  
Bile Acids ◽  
Primary Role ◽  
Drug Induced ◽  
Chronic Cholestasis ◽  
Biliary Tracts ◽  
Acute Retention ◽  
Cholestatic Liver Injury

Cholestasis results in blockage of bile flow whether the point of obstruction occurs extrahepatically or intrahepatically. Bile acids are a primary constituent of bile, and thus one of the primary outcomes is acute retention of bile acids in hepatocytes. Bile acids are normally secreted into the biliary tracts and then released into the small bowel before recirculating back to the liver. Retention of bile acids has long been hypothesized to be a primary cause of the associated liver injury that occurs during acute or chronic cholestasis. Despite this, a surge of papers in the last decade have reported a primary role for inflammation in the pathophysiology of cholestatic liver injury. Furthermore, it has increasingly been recognized that both the constituency of individual bile acids that make up the greater pool, as well as their conjugation status, is intimately involved in their toxicity, and this varies between species. Finally, the role of bile acids in drug-induced cholestatic liver injury remains an area of increasing interest. The purpose of this review is to critically evaluate current proposed mechanisms of cholestatic liver injury, with a focus on the evolving role of bile acids in cell death and inflammation.

scholarly journals Effect of ursodeoxycholic acid treatment on ileal absorption of bile acids in man as determined by the SeHCAT test.

Gut ◽  
1991 ◽  
Vol 32 (9) ◽  
pp. 1044-1048 ◽  
Author(s):  
S Eusufzai ◽  
S Ericsson ◽  
T Cederlund ◽  
K Einarsson ◽  
B Angelin
Keyword(s):  
Ursodeoxycholic Acid ◽  
Bile Acids ◽  
Acid Treatment ◽  
Ileal Absorption

Effect of chronic administration of ursodeoxycholic acid on the ileal absorption of endogenous bile acids in man

Hepatology ◽  
1990 ◽  
Vol 12 (5) ◽  
pp. 1206-1208 ◽  
Author(s):  
Philippe Marteau ◽  
Olivier Chazouiléres ◽  
Anne Myara ◽  
Raymond Jian ◽  
Jean-Claude Rambaud ◽  
...  
Keyword(s):  
Ursodeoxycholic Acid ◽  
Bile Acids ◽  
Chronic Administration ◽  
Ileal Absorption

Effect of chronic administration of ursodeoxycholic acid on the ileal absorption of endogenous bile acids in man

1989 ◽  
Vol 9 ◽  
pp. S61
Author(s):  
P. Marteau ◽  
O. Chazouillères ◽  
A. Myara ◽  
R. Jian ◽  
J.C. Rambaud ◽  
...  
Keyword(s):  
Ursodeoxycholic Acid ◽  
Bile Acids ◽  
Chronic Administration ◽  
Ileal Absorption

scholarly journals Taurine status and response to intravenous taurine supplementation in adults with short-bowel syndrome undergoing long-term parenteral nutrition: a pilot study

2006 ◽  
Vol 96 (2) ◽  
pp. 365-370 ◽  
Author(s):  
Stéphane M. Schneider ◽  
Françoise Joly ◽  
Marie-France Gehrardt ◽  
Abdul M. Badran ◽  
Anne Myara ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Bile Acids ◽  
Short Bowel Syndrome ◽  
Short Bowel ◽  
Chronic Cholestasis ◽  
Taurine Level ◽  
Taurine Deficiency ◽  
Total Bile Acids ◽  
Conjugated Bile Acids

Taurine deficiency in patients on long-term parenteral nutrition may be involved in cholestasis. We aimed to assess plasma taurine and tauro-conjugated bile acids in adults with short-bowel syndrome and their response to intravenous taurine. Thirty-two adult patients, who had been on taurine-free parenteral nutrition for a mean of 59(SE14) months for short-bowel syndrome, were studied retrospectively. In a second study, a subgroup of ten patients with chronic cholestasis received taurine-enriched (6·0(SE0·6)mg/kg per d) parenteral nutrition for 55(SE13) months. Post-absorptive plasma taurine and bile acid concentrations were measured and liver function tests routinely sampled. At baseline, plasma taurine was lower in patients with a jejunal length of less than 35cm (group A,n16) than in those with a jejunal length of 35cm or more (group B,n16): 43(SE3)v. 58(SE4)μmol/l (P=0·01). The groups were no different in terms of chronic cholestasis (1/6v.1/6 patients), total bile acids (26(SE13)v.14(SE5)μmol/l) or the ratio of tauro-conjugated:glyco-conjugated bile acids (5(SE2)v.8(SE 4)%, usual range 30–60%). After supplementation, there was an increase in plasma taurine level (63(SE8)v. 43(SE4),P=0·007) but was no change in either total bile acids or the ratio of tauro-conjugated: glyco-conjugated bile acids. There was a significant decrease in aspartate aminotransferase level. Long-term parenteral nutrition for short-bowel syndrome is associated with an impaired tauro-conjugation of bile acids (enterohepatic pool), irrespective of plasma taurine level (systemic pool) and despite long-term taurine intravenous supplementation.

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