Chromosomal mapping of loci influencing sensitivity to cocaine-induced seizures in BXD recombinant inbred strains of mice

1995 ◽  
Vol 117 (1) ◽  
pp. 62-66 ◽  
Author(s):  
Lucinda L. Miner ◽  
Rodney J. Marley
1972 ◽  
Vol 55 (2) ◽  
pp. 415-420 ◽  
Author(s):  
B. E. ELEFTHERIOU ◽  
D. W. BAILEY

SUMMARY Plasma corticosterone levels were determined fluorometrically in mice of two unrelated highly inbred strains, C57BL/6By and BALB/cBy, and in seven of their derived recombinant-inbred strains as well as their F1 hybrid and backcross generations necessary to arrive at a genetic model for plasma corticosterone levels. It was concluded that the simplest genetic model, and one which fits the experimental results, was one which assumed that plasma corticosterone levels are controlled genetically by two loci with the epistatic interaction indicating dependency of pathways of action for the two genes.


2018 ◽  
Vol 9 ◽  
Author(s):  
Megan K. Mulligan ◽  
Wenyuan Zhao ◽  
Morgan Dickerson ◽  
Danny Arends ◽  
Pjotr Prins ◽  
...  

2008 ◽  
Vol 33 (8) ◽  
pp. 693-707 ◽  
Author(s):  
D. J. Reiner ◽  
T. A. Jan ◽  
J. D. Boughter ◽  
C.-X. Li ◽  
L. Lu ◽  
...  

1981 ◽  
Vol 38 (3) ◽  
pp. 327-331 ◽  
Author(s):  
M. Vekemans ◽  
B. A. Taylor ◽  
F. C. Fraser

SUMMARYRecombinant-inbred (RI) strains of mice derived from the cross of strains C57BL/6J and DBA/2J were used to study the inheritance of susceptibility to cortisone-induced cleft palate. Most of the RI strains could be classified as either resistant, like C57BL/6J, or susceptible, like DBA/2J, suggesting the segregation of a major locus. An association with the phosphoglucomutase-1 locus (Pgm-1) on Chromosome 5 was observed. There was no association with the H-2 locus on Chromosome 17 as had been reported in previous studies utilizing different strains. We conclude that susceptibility to cortisone-induced cleft palate may be determined by different loci depending on the strains studied.


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