scholarly journals The susceptibility to cortisone-induced cleft palate of recombinant inbred strains of mice: lack of association with the H-2 haplotype

1981 ◽  
Vol 38 (3) ◽  
pp. 327-331 ◽  
Author(s):  
M. Vekemans ◽  
B. A. Taylor ◽  
F. C. Fraser
Keyword(s):  
Cleft Palate ◽  
Recombinant Inbred ◽  
Inbred Strains ◽  
Chromosome 17 ◽  
Recombinant Inbred Strains ◽  
Chromosome 5 ◽  
Major Locus ◽  
Inbred Strains Of Mice ◽  
The Cross ◽  
Different Strains

SUMMARYRecombinant-inbred (RI) strains of mice derived from the cross of strains C57BL/6J and DBA/2J were used to study the inheritance of susceptibility to cortisone-induced cleft palate. Most of the RI strains could be classified as either resistant, like C57BL/6J, or susceptible, like DBA/2J, suggesting the segregation of a major locus. An association with the phosphoglucomutase-1 locus (Pgm-1) on Chromosome 5 was observed. There was no association with the H-2 locus on Chromosome 17 as had been reported in previous studies utilizing different strains. We conclude that susceptibility to cortisone-induced cleft palate may be determined by different loci depending on the strains studied.

GENETIC ANALYSIS OF PLASMA CORTICOSTERONE LEVELS IN TWO INBRED STRAINS OF MICE

1972 ◽  
Vol 55 (2) ◽  
pp. 415-420 ◽  
Author(s):  
B. E. ELEFTHERIOU ◽  
D. W. BAILEY
Keyword(s):  
Genetic Analysis ◽  
Recombinant Inbred ◽  
Epistatic Interaction ◽  
Genetic Model ◽  
Inbred Strains ◽  
Plasma Corticosterone ◽  
Experimental Results ◽  
Recombinant Inbred Strains ◽  
Inbred Strains Of Mice

SUMMARY Plasma corticosterone levels were determined fluorometrically in mice of two unrelated highly inbred strains, C57BL/6By and BALB/cBy, and in seven of their derived recombinant-inbred strains as well as their F1 hybrid and backcross generations necessary to arrive at a genetic model for plasma corticosterone levels. It was concluded that the simplest genetic model, and one which fits the experimental results, was one which assumed that plasma corticosterone levels are controlled genetically by two loci with the epistatic interaction indicating dependency of pathways of action for the two genes.

scholarly journals Genetic Contribution to Initial and Progressive Alcohol Intake Among Recombinant Inbred Strains of Mice

2018 ◽  
Vol 9 ◽  
Author(s):  
Megan K. Mulligan ◽  
Wenyuan Zhao ◽  
Morgan Dickerson ◽  
Danny Arends ◽  
Pjotr Prins ◽  
...  
Keyword(s):  
Recombinant Inbred ◽  
Alcohol Intake ◽  
Inbred Strains ◽  
Recombinant Inbred Strains ◽  
Genetic Contribution ◽  
Inbred Strains Of Mice

scholarly journals Genetic Analysis of Tongue Size and Taste Papillae Number and Size in Recombinant Inbred Strains of Mice

2008 ◽  
Vol 33 (8) ◽  
pp. 693-707 ◽  
Author(s):  
D. J. Reiner ◽  
T. A. Jan ◽  
J. D. Boughter ◽  
C.-X. Li ◽  
L. Lu ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Recombinant Inbred ◽  
Inbred Strains ◽  
Recombinant Inbred Strains ◽  
Inbred Strains Of Mice

scholarly journals Susceptibility to phenytoin-induced cleft lip with or without cleft palate: many genes are involved

1987 ◽  
Vol 49 (1) ◽  
pp. 43-49 ◽  
Author(s):  
I. Jill Karolyi ◽  
Sharon Liu ◽  
Robert P. Erickson
Keyword(s):  
Glucocorticoid Receptor ◽  
Cleft Palate ◽  
Recombinant Inbred ◽  
Cleft Lip ◽  
Inbred Strains ◽  
Cyclic Monophosphate ◽  
Major Histocompatibility Locus ◽  
Inbred Strains Of Mice ◽  
Histocompatibility Locus ◽  
Isolated Cleft Palate

SummaryIn a search for genetic differences in susceptibility to cleft lip with or without cleft palate [CL(P)], congenic and recombinant inbred strains of mice were treated with phenytoin or control injections. Of six loci tested, five were found to affect susceptibility to phenytoin-induced and/or sporadic CL(P): (1) the major histocompatibility locus, H-2; (2) the locus controlling β2-microglobulin, B2m; (3) a locus controlling β-glucuronidase, Gus; (4) the locus controlling N-acetyl transferase, Nat; and (5) the locus for brown pigmentation, b. B2m and Gus only affected the sporadic incidence of CL(P), while the b locus only affected phenytoin-induced incidence of CL(P). Three of these loci are also known to affect glucocorticoid-induced isolated cleft palate (CP), but different alleles of the loci are involved. Phenytoin did not affect levels of adenosine 3′,5′-cyclic monophosphate (cAMP) in palates and tongues of day 15 fetuses. A comparison of glucocorticoid receptor parameters with the incidence of phenytoin-induced CL(P) found no correlation.

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