Significance of rheumatoid factor isotypes in seronegative rheumatoid arthritis

1990 ◽  
Vol 10 (1) ◽  
pp. 43-46 ◽  
Author(s):  
F. Eggelmeijer ◽  
H. G. Otten ◽  
H. H. de Rooy ◽  
M. R. Daha ◽  
F. C. Breedveld
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factor ◽  
Rheumatoid Factor Isotypes

Anti-citrullinated peptide antibodies and rheumatoid factor isotypes in the diagnosis of rheumatoid arthritis: an assessment of combined tests

2014 ◽  
Vol 436 ◽  
pp. 237-242 ◽  
Author(s):  
Maria Infantino ◽  
Mariangela Manfredi ◽  
Francesca Meacci ◽  
Piercarlo Sarzi-Puttini ◽  
Cristian Ricci ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factor ◽  
Rheumatoid Factor Isotypes ◽  
Citrullinated Peptide ◽  
Peptide Antibodies

AB0111 Development of anti–citrullinated protein antibody and rheumatoid factor isotypes in relation to smoking prior to the onset of rheumatoid arthritis

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A819.2-A819
Author(s):  
W. Bos ◽  
L. van de Stadt ◽  
A. Sohrabian ◽  
J. Ronnelid ◽  
D. van Schaardenburg
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factor ◽  
Rheumatoid Factor Isotypes ◽  
Citrullinated Protein

scholarly journals Smoking, rheumatoid factor isotypes and severity of rheumatoid arthritis

Rheumatology ◽  
2000 ◽  
Vol 39 (11) ◽  
pp. 1202-1205 ◽  
Author(s):  
B. Másdóttir ◽  
T. Jónsson ◽  
V. Manfreðsdóttir ◽  
A. Víkingsson ◽  
Á. Brekkan ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factor ◽  
Rheumatoid Factor Isotypes

scholarly journals Anti–Citrullinated Protein Antibody Specificities, Rheumatoid Factor Isotypes, and Incident Cardiovascular Events in Patients With Rheumatoid Arthritis

2020 ◽  
Vol 72 (10) ◽  
pp. 1658-1667
Author(s):  
Helga Westerlind ◽  
Johan Rönnelid ◽  
Monika Hansson ◽  
Lars Alfredsson ◽  
Linda Mathsson‐Alm ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factor ◽  
Cardiovascular Events ◽  
Rheumatoid Factor Isotypes ◽  
Antibody Specificities ◽  
Citrullinated Protein

scholarly journals FRI0588 DIAGNOSTIC PERFORMANCE OF THE RHEUMATOID FACTOR ISOTYPES IN RHEUMATIC DISEASES

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 899.2-899
Author(s):  
R. Pineda-Sic ◽  
D. Vega-Morales ◽  
L. Santoyo-Fexas ◽  
M. M. Castañeda-Martínez ◽  
I. D. J. Hernandez-Galarza ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factor ◽  
Sensitivity And Specificity ◽  
Rheumatic Diseases ◽  
Roc Curve ◽  
Lupus Erythematosus ◽  
Diagnostic Performance ◽  
Youden Index ◽  
Rheumatoid Factor Isotypes

Background:Rheumatoid Factor (RF) is used for the classification of Rheumatoid arthritis (RA) in patients whose main complaint is hand arthritis but is well known that other conditions have positive RF. Differences in analytical performance between assays were found in previous studies, there was a poor numerical agreement, and using the cut-off proposed by the manufacturer, variation in sensitivity and specificity can be seen.2Objectives:To determine the cut-off value for RF with the best diagnostic performance for RA in patients with hand arthritis compared with their main differential diagnoses.Methods:Descriptive, cross-sectional, diagnostic test study. Sampling size was calculated 2:1, with the area under the ROC curve (AUC): 0.708, power 80% and significance 0.05. Patients with RA, Systemic Lupus Erythematosus (SLE), Osteoarthritis (OA), fibromyalgia (FBM), Polyarticular Gout (PG), Psoriatic Arthritis(Psa), Sjögren Syndrome (SS), Arthralgia suspicious for progression to RA (ASP) and healthy subjects, previously classified with the current criteria by certified rheumatologist were included. EUROINMMUN ® assays for RF isotypes IgA, IgM, IgG were used. ROC curves and Youden index for determining the cut-off with the best sensitivity and specificity for each RF isotype comparing RA with other diseases were used. Statistical analyses were performed with SPSS V.24.Results:Three hundred and thirty-two serum samples from patients were included, in the other rheumatic diseases different from RA, we found positive RF IgM in 141 (45.5%), 82 (26.5%) IgA and 25 (8.1%) IgG. For each clinical scenario the cut-off with the best sensitivity and specificity was different from the manufacturer proposed, and isotypes with the best diagnostic performance was not the same for each disease, Table 1. We present the ROC curve for RF isotypes in Figure 1.Conclusion:In order to improve the diagnosis of Rheumatoid Arthritis, different cut-off points of RF and isotypes should be used.References:[1] Van Hoovels L, Jacobs J, Vander Cruyssen B, Van Den Bremt S, Verschueren P, Bossuyt X. Performance characteristics of rheumatoid factor and anti-cyclic citrullinated peptide antibody assays may impact ACR/EULAR classification of rheumatoid arthritis. Ann Rheum Dis. 2018;77(5):667-677. doi:10.1136/annrheumdis-2017-212365[2] Van Boekel MAM, Vossenaar ER, Van Den Hoogen FHJ, Van Venrooij WJ. Autoantibody systems in rheumatoid arthritis: Specificity, sensitivity and diagnostic value. Arthritis Res. 2002;4(2):87-93. doi:10.1186/ar395.Disclosure of Interests:None declared

scholarly journals AB1461-HPR Frequency of rheumatoid factor isotypes in paraguayan patients with rheumatoid arthritis

2018 ◽  
Author(s):  
L Roman ◽  
S. Riquelme-Granada ◽  
G. Avila-Pedreti ◽  
I. Acosta-Colman ◽  
M.E. Acosta ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factor ◽  
Rheumatoid Factor Isotypes
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