Pharmacokinetics of eltanolone following bolus injection and constant rate infusion

1996 ◽  
Vol 24 (6) ◽  
pp. 535-549 ◽  
Author(s):  
Kourosh Parivar ◽  
Arne Wessén ◽  
Marianne Widman ◽  
Anders Nilsson
Keyword(s):  
Bolus Injection ◽  
Constant Rate Infusion ◽  
Constant Rate ◽  
Rate Infusion

Counterregulation of insulin-induced hypoglycaemia in primary hypothyroidism

1986 ◽  
Vol 111 (4) ◽  
pp. 516-521
Author(s):  
Nina Clausen ◽  
Per-Eric Lins ◽  
Ulf Adamson ◽  
Bertil Hamberger ◽  
Suad Efendić
Keyword(s):  
Growth Hormone ◽  
Insulin Infusion ◽  
Primary Hypothyroidism ◽  
Constant Rate Infusion ◽  
Counterregulatory Hormones ◽  
Insulin Metabolism ◽  
Hormonal Responses ◽  
Glucose Levels ◽  
Constant Rate ◽  
Rate Infusion

Abstract. Hypothyroidism has been alleged to modulate insulin action and influence the secretion of growth hormone and catecholamines. We recently investigated the influence of hypothyroidism on glucose counterregulatory capacity and the hormonal responses to insulin-induced hypoglycaemia in 6 patients with primary hypothyroidism (age 32–52 years, TSH-values 66–200 mU/l). Hypoglycaemia was induced in the hypothyroid state and again when the subjects were euthyroid. After an overnight fast a constant rate infusion of insulin (2.4 U/h) was given for 4 h. Glucose was measured every 15 min and insulin, C-peptide, glucagon, epinephrine, norepinephrine, growth hormone and cortisol every 30 min for 5 h. During insulin infusion somewhat higher concentrations of the hormone were obtained in the hypothyroid state and simultaneously glucose levels were 0.5 mmol/l lower. As expected, basal norepinephrine levels were higher in hypothyroidism. However, no increase in circulating norepinephrine during hypoglycaemia was registered in the two experiments. The responses of counterregulatory hormones showed an enhanced response of cortisol, similar responses of growth hormone and epinephrine while the glucagon response was paradoxically impaired. Our findings suggest that hypothyroidism alters insulin metabolism, and that the glucagon response to hypoglycaemia is impaired in this condition.

Pharmacokinetics and pharmacodynamics of a constant rate infusion of fentanyl (5 μg/kg/h) in awake cats

2014 ◽  
Vol 75 (8) ◽  
pp. 716-721 ◽  
Author(s):  
Barbara Ambros ◽  
Jane Alcorn ◽  
Tanya Duke-Novakovski ◽  
Alexander Livingston ◽  
Patricia M. Dowling
Keyword(s):  
Pharmacokinetics And Pharmacodynamics ◽  
Constant Rate Infusion ◽  
Constant Rate ◽  
Awake Cats ◽  
Rate Infusion

Anaesthetic and cardiorespiratory effects of a constant-rate infusion of alfaxalone in desflurane-anaesthetised sheep

2012 ◽  
Vol 171 (5) ◽  
pp. 125-125 ◽  
Author(s):  
M. del Mar Granados ◽  
J. Manuel Domínguez ◽  
A. Fernández-Sarmiento ◽  
F. Javier Funes ◽  
J. Morgaz ◽  
...  
Keyword(s):  
Constant Rate Infusion ◽  
Constant Rate ◽  
Rate Infusion

Behavioural and cardiorespiratory effects of a constant rate infusion of medetomidine and morphine for sedation during standing laparoscopy in horses

2009 ◽  
Vol 41 (2) ◽  
pp. 153-159 ◽  
Author(s):  
A. M. SOLANO ◽  
A. VALVERDE ◽  
A. DESROCHERS ◽  
S. NYKAMP ◽  
L. P. BOURE
Keyword(s):  
Constant Rate Infusion ◽  
Constant Rate ◽  
Rate Infusion

Postoperative analgesic effects of either a constant rate infusion of fentanyl, lidocaine, ketamine, dexmedetomidine, or the combination lidocaine-ketamine-dexmedetomidine after ovariohysterectomy in dogs

2015 ◽  
Vol 42 (3) ◽  
pp. 309-318 ◽  
Author(s):  
Eduardo Gutierrez-Blanco ◽  
José M Victoria-Mora ◽  
José A Ibancovichi-Camarillo ◽  
Carlos H Sauri-Arceo ◽  
Manuel E Bolio-González ◽  
...  
Keyword(s):  
Constant Rate Infusion ◽  
Analgesic Effects ◽  
Constant Rate ◽  
Rate Infusion
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