Elevation of gastric blood flow as the mechanism of antiulcer effects of Pro-Gly-Pro

2000 ◽  
Vol 129 (2) ◽  
pp. 112-113 ◽  
Author(s):  
N. Ya. Zhelyaznek ◽  
G. E. Samonina ◽  
V. I. Sergeev ◽  
I. P. Ashmarin
Keyword(s):  
Blood Flow ◽  
Gastric Blood Flow

scholarly journals Novel Hydrogen Sulfide (H2S)-Releasing BW-HS-101 and Its Non-H2S Releasing Derivative in Modulation of Microscopic and Molecular Parameters of Gastric Mucosal Barrier

2021 ◽  
Vol 22 (10) ◽  
pp. 5211
Author(s):  
Dominik Bakalarz ◽  
Edyta Korbut ◽  
Zhengnan Yuan ◽  
Bingchen Yu ◽  
Dagmara Wójcik ◽  
...  
Keyword(s):  
Blood Flow ◽  
Hydrogen Sulfide ◽  
Gastric Mucosa ◽  
Dna Oxidation ◽  
Gastric Blood Flow ◽  
Gastric Mucosal Damage ◽  
Mucosal Barrier ◽  
Gastric Injury ◽  
Zinc Protoporphyrin ◽  
Anti Inflammatory

Hydrogen sulfide (H2S) is an endogenously produced molecule with anti-inflammatory and cytoprotective properties. We aimed to investigate for the first time if a novel, esterase-sensitive H2S-prodrug, BW-HS-101 with the ability to release H2S in a controllable manner, prevents gastric mucosa against acetylsalicylic acid-induced gastropathy on microscopic and molecular levels. Wistar rats were pretreated intragastrically with vehicle, BW-HS-101 (0.5–50 μmol/kg) or its analogue without the ability to release H2S, BW-iHS-101 prior to ASA administration (125 mg/kg, intragastrically). BW-HS-101 was administered alone or in combination with nitroarginine (L-NNA, 20 mg/kg, intraperitoneally) or zinc protoporphyrin IX (10 mg/kg, intraperitoneally). Gastroprotective effects of BW-HS-101 were additionally evaluated against necrotic damage induced by intragastrical administration of 75% ethanol. Gastric mucosal damage was assessed microscopically, and gastric blood flow was determined by laser flowmetry. Gastric mucosal DNA oxidation and PGE2 concentration were assessed by ELISA. Serum and/or gastric protein concentrations of IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-10, IL-13, VEGF, GM-CSF, IFN-γ, TNF-α, and EGF were determined by a microbeads/fluorescent-based multiplex assay. Changes in gastric mucosal iNOS, HMOX-1, SOCS3, IL1-R1, IL1-R2, TNF-R2, COX-1, and COX-2 mRNA were assessed by real-time PCR. BW-HS-101 or BW-iHS-101 applied at a dose of 50 μmol/kg protected gastric mucosa against ASA-induced gastric damage and prevented a decrease in the gastric blood flow level. H2S prodrug decreased DNA oxidation, systemic and gastric mucosal inflammation with accompanied upregulation of SOCS3, and EGF and HMOX-1 expression. Pharmacological inhibition of nitric oxide (NO) synthase but not carbon monoxide (CO)/heme oxygenase (HMOX) activity by L-NNA or ZnPP, respectively, reversed the gastroprotective effect of BW-HS-101. BW-HS-101 also protected against ethanol-induced gastric injury formation. We conclude that BW-HS-101, due to its ability to release H2S in a controllable manner, prevents gastric mucosa against drugs-induced gastropathy, inflammation and DNA oxidation, and upregulate gastric microcirculation. Gastroprotective effects of this H2S prodrug involves endogenous NO but not CO activity and could be mediated by cytoprotective and anti-inflammatory SOCS3 and EGF pathways.

scholarly journals Famotidine prevents canine gastric blood flow reduction by NSAIDs

2005 ◽  
Vol 21 (s2) ◽  
pp. 55-59 ◽  
Author(s):  
J. Hata ◽  
T. Kamada ◽  
N. Manabe ◽  
H. Kusunoki ◽  
D. Kamino ◽  
...  
Keyword(s):  
Blood Flow ◽  
Gastric Blood Flow ◽  
Flow Reduction ◽  
Blood Flow Reduction

Effects of histamine on gastric blood flow

1962 ◽  
Vol 7 (5) ◽  
pp. 383-393 ◽  
Author(s):  
Rene Menguy
Keyword(s):  
Blood Flow ◽  
Gastric Blood Flow

Effect of PGI2, PGE2 and 6-keto PGF1α on canine gastric blood flow and acid secretion

1978 ◽  
Vol 16 (5) ◽  
pp. 815-823 ◽  
Author(s):  
John F. Gerkens ◽  
John G. Gerber ◽  
David G. Shand ◽  
Robert A. Branch
Keyword(s):  
Blood Flow ◽  
Acid Secretion ◽  
Gastric Blood Flow

scholarly journals Rostral ventrolateral medulla regulates pancreatic and gastric blood flow

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Anthony J.M. Verberne ◽  
Kathleen M McInerney
Keyword(s):  
Blood Flow ◽  
Rostral Ventrolateral Medulla ◽  
Gastric Blood Flow ◽  
Ventrolateral Medulla

RECENT OBSERVATIONS ON GASTRIC BLOOD FLOW AND ACID SECRETION

1967 ◽  
pp. 53-72 ◽  
Author(s):  
JACK RUDICK ◽  
WARREN G. GUNTHEROTH ◽  
LLOYD M. NYHUS
Keyword(s):  
Blood Flow ◽  
Acid Secretion ◽  
Gastric Blood Flow

Experimentally induced variations in canine gastric blood flow and its distribution

1965 ◽  
Vol 208 (2) ◽  
pp. 353-358 ◽  
Author(s):  
John P. Delaney ◽  
Eugene Grim
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Gastric Secretion ◽  
Vascular Resistance ◽  
Tissue Perfusion ◽  
Gastric Blood Flow ◽  
Gastric Tissue ◽  
Distribution Of Flow ◽  
Experimentally Induced

Total gastric blood flow and its distribution between antrum and corpus, and to the mucosa, submucosa, and muscularis of the corpus were measured in dogs under the influence of several agents known to affect gastric secretion. Histamine, infused intravenously or administered chronically in beeswax intramuscularly, produced increases in cardiac output, the fraction of the output going to the stomach and, hence, gastric tissue perfusion Epinephrine infusions also caused significant increases in cardiac output and gastric perfusion. Norepinephrine was the only agent that raised gastric vascular resistance; despite an increase in cardiac output, blood flow to the stomach fell. Neither intravenous secretin nor inspired 10% CO2 affected gastric perfusion. All agents except histamine increased the antrum/corpus perfusion ratio. Only norepinephrine altered the distribution of flow to the several tissues of the corpus; it caused a shift of flow from mucosa to muscle. The results provide no support for the frequently stated conclusion that gastric blood flow and secretion are closely related.

Gastric blood flow and secretion in conscious dogs

1967 ◽  
Vol 212 (4) ◽  
pp. 891-896 ◽  
Author(s):  
KG Swan ◽  
ED Jacobson
Keyword(s):  
Blood Flow ◽  
Conscious Dogs ◽  
Gastric Blood Flow

Effect of thoracic epidural analgesia on gastric blood flow after oesophagectomy

2007 ◽  
Vol 51 (5) ◽  
pp. 587-594 ◽  
Author(s):  
P. Michelet ◽  
A. Roch ◽  
X.-B. D?Journo ◽  
D. Blayac ◽  
K. Barrau ◽  
...  
Keyword(s):  
Blood Flow ◽  
Epidural Analgesia ◽  
Thoracic Epidural Analgesia ◽  
Gastric Blood Flow ◽  
Thoracic Epidural
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