Substance P analogues act as broad-spectrum neuropeptide antagonists

1998 ◽  
Vol 5 (2-3) ◽  
pp. 199-204
Author(s):  
Michael J. Seckl ◽  
Enrique Rozengurt
Keyword(s):  
Substance P ◽  
Broad Spectrum ◽  
Neuropeptide Antagonists ◽  
Substance P Analogues

The molecular mechanism of action of substance P (SP) analogue broad spectrum neuropeptide antagonists

Lung Cancer ◽  
2000 ◽  
Vol 29 (1) ◽  
pp. 191-192
Author(s):  
M.J Seckl ◽  
A Weinglass ◽  
Q Li
Keyword(s):  
Substance P ◽  
Molecular Mechanism ◽  
Mechanism Of Action ◽  
Broad Spectrum ◽  
Molecular Mechanism Of Action ◽  
Neuropeptide Antagonists

Inhibition of cholecystokinin (CCK) binding and signaling by broad-spectrum substance P analogues is at the receptor level

2000 ◽  
Vol 118 (4) ◽  
pp. A310-A311
Author(s):  
Shuping V. Wu ◽  
Moon Yang ◽  
John H. Walsh ◽  
Enrique Rozengurt
Keyword(s):  
Substance P ◽  
Broad Spectrum ◽  
Receptor Level ◽  
Substance P Analogues

Addressing substrate glutamine requirements for tissue transglutaminase using substance P analogues

FEBS Letters ◽  
1999 ◽  
Vol 451 (3) ◽  
pp. 231-234 ◽  
Author(s):  
María Teresa Pastor ◽  
Antonio Diez ◽  
Enrique Pérez-Payá ◽  
Concepción Abad
Keyword(s):  
Substance P ◽  
Tissue Transglutaminase ◽  
Substance P Analogues

Antinociceptive effects in the formalin and capsaicin tests after intrathecal administration of substance P analogues in mice

1993 ◽  
Vol 242 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Tsukasa Sakurada ◽  
Kazushige Katsumata ◽  
Yoichi Manome ◽  
Koichi Tan-No ◽  
Shinobu Sakurada ◽  
...  
Keyword(s):  
Substance P ◽  
Intrathecal Administration ◽  
Antinociceptive Effects ◽  
Substance P Analogues

Effects of substance P analogues on spinal dorsal horn neurons

Peptides ◽  
1988 ◽  
Vol 9 (3) ◽  
pp. 651-660 ◽  
Author(s):  
M. Randic ◽  
S. Jeftinija ◽  
L. Urban ◽  
C. Raspantini ◽  
K. Folkers
Keyword(s):  
Substance P ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Dorsal Horn Neurons ◽  
Spinal Dorsal ◽  
Spinal Dorsal Horn Neurons ◽  
Substance P Analogues

Internalization of [3H]Substance P Analogues in NK-1 Receptor Transfected CHO Cells

2001 ◽  
Vol 282 (4) ◽  
pp. 958-964 ◽  
Author(s):  
Sandrine Sagan ◽  
Solange Lavielle
Keyword(s):  
Substance P ◽  
Cho Cells ◽  
Substance P Analogues

Substance P analogues potentiate the pressor response to microinjection of l-glutamate into laminas I and II of the cat dorsal horn

1997 ◽  
Vol 759 (1) ◽  
pp. 175-179 ◽  
Author(s):  
Christian A Beyaert ◽  
Janeen M Hill ◽  
Marc P Kaufman
Keyword(s):  
Substance P ◽  
Dorsal Horn ◽  
Pressor Response ◽  
Substance P Analogues

Effects of Substance P and Substance P Antagonists on Rat Salivary Secretion

1986 ◽  
Vol 65 (12) ◽  
pp. 1427-1431 ◽  
Author(s):  
E. Bobyock ◽  
E.J. Barbieri ◽  
W.S. Chernick
Keyword(s):  
Substance P ◽  
Salivary Secretion ◽  
Arterial Infusion ◽  
Anesthetized Rats ◽  
Substance P Antagonists ◽  
Substance P Analogues

The intra-arterial infusion of substance P produced dose-related responses of both parotid and submandibular salivary secretion in anesthetized rats. The substance P-induced secretion in both glands was inhibited by the substance P analogues [D-Arg 1, D-Trp7,9, Leu11 ]-substance P and [D-Arg1, D-Pro2, D-Trp7,9, Leu11 ]-substance P, but not by [D-Pro2 , D-Trp7,9]-substance P. The profiles of protein and calcium levels obtained with substance P-induced salivary secretion for both glands were similar to those produced by acetylcholine stimulation and were not altered by the substance P analogues.

Characterization of spinal actions of four substance P analogues

1985 ◽  
Vol 110 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Réjean Couture ◽  
Kiran Yashpal ◽  
James L. Henry ◽  
Emanuel Escher ◽  
Domenico Regoli
Keyword(s):  
Substance P ◽  
Substance P Analogues
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