Production of granulocytic colony-stimulating factor in patients with chronic myeloleukemia

1998 ◽  
Vol 126 (1) ◽  
pp. 724-727
Author(s):  
M. Ya. Lisovskii ◽  
G. Yu. Miterev ◽  
N. D. Khoroshko ◽  
V. G. Savchenko
Keyword(s):  
Colony Stimulating Factor ◽  
Granulocytic Colony ◽  
Stimulating Factor

Mobilization of Progenitor Cells into the Blood by Immobilized Granulocytic Colony-Stimulating Factor

2009 ◽  
Vol 147 (4) ◽  
pp. 499-502 ◽  
Author(s):  
A. M. Dygai ◽  
E. I. Vereshchagin ◽  
G. N. Zyuz’kov ◽  
V. V. Zhdanov ◽  
P. G. Madonov ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Colony Stimulating Factor ◽  
Granulocytic Colony ◽  
Stimulating Factor

scholarly journals Interleukin-1 synergizes with granulocyte-macrophage colony-stimulating factor on granulocytic colony formation by intermediate production of granulocyte colony-stimulating factor

Blood ◽  
1989 ◽  
Vol 74 (7) ◽  
pp. 2398-2404 ◽  
Author(s):  
MR Schaafsma ◽  
JH Falkenburg ◽  
N Duinkerken ◽  
J Van Damme ◽  
BW Altrock ◽  
...  
Keyword(s):  
Bone Marrow Cells ◽  
Interleukin 1 ◽  
Colony Growth ◽  
Colony Stimulating Factor ◽  
Gm Csf ◽  
Accessory Cells ◽  
Granulocytic Colony ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

Abstract Interleukin-1 (IL-1) was found to act synergistically with granulocyte- macrophage colony-stimulating factor (GM-CSF) on granulocytic colony growth of normal human bone marrow cells, depleted of mononuclear phagocytes and T lymphocytes. Using CD34/HLA-DR-enriched bone marrow cells we demonstrated that this activity of IL-1 was not a direct action on hematopoietic progenitor cells, but an effect of an intermediate factor produced by residual accessory cells in response to IL-1. Neutralization experiments using an anti-IL-6 antiserum showed that IL-1-induced IL-6 did not contribute to the observed synergy. Furthermore, IL-6 by itself had neither a direct stimulatory effect on CFU-GM colony growth, nor did it act synergistically with GM-CSF on granulocytic or monocytic colony formation. Neutralization experiments with an anti-G-CSF monoclonal antibody showed that IL-1-induced G-CSF production was responsible for the synergy with GM-CSF. Using combinations of G-CSF and GM-CSF this synergistic activity could be detected at concentrations of G-CSF as low as 0.1 ng/mL (10 U/mL). Our results indicate that IL-1, but not IL-6, stimulates the GM-CSF- dependent proliferation of relatively mature myeloid progenitor cells in the presence of small numbers of accessory cells.

scholarly journals Effects of human interleukin-3 on granulocytic colony-forming cells in human bone marrow

Blood ◽  
1989 ◽  
Vol 73 (5) ◽  
pp. 1157-1160 ◽  
Author(s):  
FJ Bot ◽  
L van Eijk ◽  
P Schipper ◽  
B Lowenberg
Keyword(s):  
Colony Formation ◽  
In Vitro Cultures ◽  
Colony Stimulating Factor ◽  
Hematopoietic Progenitor ◽  
Interleukin 3 ◽  
Proliferative Rate ◽  
Granulocytic Colony ◽  
Immature Cells ◽  
Stimulating Factor

Abstract Human multilineage colony-stimulating factor (multi-CSF)/interleukin-3 (IL-3) induces colony formation from CFU-GEMM, BFU-E, and CFU-Eo when applied to in vitro cultures of highly enriched hematopoietic progenitor cells. No granulocytic colonies are formed in response to IL- 3. However, with appropriate assays, we demonstrate that IL-3 increases the size of G-CSF-induced granulocytic colonies; these colonies contain greater proportions of immature cells as compared with colonies stimulated by G-CSF alone. Furthermore, IL-3 promotes the survival of CFU-G in vitro, whereas in cultures not supplemented with IL-3, CFU-G extinguish within seven days. We conclude that IL-3, although it does not stimulate granulocytic colony formation by itself, regulates the survival and proliferative rate of granulocytic progenitors.

Evaluation of the Efficacy of Granulocytic Colony-Stimulating Factor for the Treatment of Experimental Myocardial Destruction in Mice

2010 ◽  
Vol 149 (1) ◽  
pp. 131-134
Author(s):  
S. A. Afanas’ev ◽  
Yu. V. Rogovskaya ◽  
V. V. Ryabov ◽  
L. P. Falaleeva ◽  
I. N. Sviridov ◽  
...  
Keyword(s):  
Colony Stimulating Factor ◽  
Granulocytic Colony ◽  
Stimulating Factor

Effect of Granulocytic Colony-Stimulating Factor on Cytostatic-Suppressed Granulocytopoiesis under Conditions of Exhausted Catecholamine Depot

2009 ◽  
Vol 147 (5) ◽  
pp. 609-612 ◽  
Author(s):  
A. M. Dygai ◽  
E. G. Skurikhin ◽  
O. V. Pershina ◽  
E. V. Simanina ◽  
M. Yu. Minakova ◽  
...  
Keyword(s):  
Colony Stimulating Factor ◽  
Granulocytic Colony ◽  
Stimulating Factor
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